Asthma-like symptoms in young children increase the risk of COPD

Bisgaard, Hans; Nørgaard, Sarah; Sevelsted, Astrid; Chawes, Bo; Stokholm, Jakob; Mortensen, Erik Lykke; Ulrik, Charlotte Suppli; Bønnelykke, Klaus

doi:10.1016/j.jaci.2020.05.043

Cited by 21 publications

(15 citation statements)

References 33 publications

(38 reference statements)

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“…Table 1 summarizes the characteristics of each study. The association between risk of adult COPD and childhood serious respiratory infections, pneumonia or bronchitis was reported in 14 studies 6,7,15,16,[20][21][22][23][24][25][26][27][28]50 ; childhood asthma in nine studies 8,15,16,20,28,[34][35][36][37] ; maternal smoking in seven studies 6,15,18,19,23,37,41,51 ; CETS in two studies 40,41 ; child maltreatment in five studies [29][30][31][32][33] ; low birth weight in three studies 6,23,39 ; and premature birth in three studies. 23,28,39 Included participants were older than 40 years, except for studies from the European Community Respiratory Health Survey, in which the average age was about 36 years.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…15,18 Two studies defined early life exposures based on discharge registers or paediatrician diagnosis 20,39 and the others based on self-reports. 15,16,18,19,31,37 Most cohort studies used the GOLD lung function criteria to define COPD, and only two studies 19,37 used prebronchodilator spirometry or discharge records to define COPD. Five articles 15,16,18,20,37 described participants lost to follow-up, but their detailed information was not provided.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Strong evidence suggests that childhood asthma is associated with increased risk of COPD. 8,16,20,28,[34][35][36][37] Also, the risk of COPD may be greater with chronic childhood asthma than smoking. 38 Therefore, a quantitative evaluation of the risk of COPD in individuals with childhood asthma is needed.…”

Section: Introductionmentioning

confidence: 99%

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Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

et al. 2021

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Early life represents a critical period for the development and growth of the lungs. Adverse exposures in this stage may drive the development of chronic obstructive pulmonary disease (COPD). Thus, we quantitatively evaluated the impact of different early life exposures on COPD in adulthood. The PubMed, Embase and Cochrane Library electronic databases were searched for articles published from January 2001 to October 2020. A total of 30 studies (795,935 participants) met the criteria and were included in the review. We found a significant association of COPD with childhood serious respiratory infections, pneumonia or bronchitis (pooled adjusted OR [aOR], 2.23 [95% CI, 1.63-3.07]). The probability of COPD was increased 3.45-fold for children with than without asthma (pooled aOR, 3.45 [95% CI, 2.37-5.02]). In addition, the probability of COPD was associated with maternal smoking (pooled aOR, 1.42 [95% CI, 1.17-1.72]), any child maltreatment (pooled aOR, 1.30 [95% CI, 1.18-1.42]) and low birth weight (pooled aOR, 1.58 [95% CI, 1.08-2.32]) but not childhood environmental tobacco smoke exposure (pooled aOR,) or premature birth (pooled aOR, 1.17 [95% CI, 0.87-1.58]). Furthermore, subgroup analyses revealed that probability was increased for only women with childhood physical abuse, sexual abuse and exposure to intimate partner violence. Factors resulting in COPD in adults could trace back to early life. Childhood respiratory disease, maltreatment, maternal smoking and low birth weight increase the risk of COPD. Promising advances in prevention strategies for early life exposures could markedly decrease the risk of COPD.K E Y W O R D S chronic obstructive pulmonary disease, COPD in adulthood, early life exposure, risk factor, systematic review and meta-analysis

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Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

et al. 2021

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“…In the "Paediatric Year in Review", an overview of the results of important studies on asthma in the past year were presented by Prof. Klaus Bonnelykke, including that: vitamin D supplementation during pregnancy seems to prevent preschool asthma symptoms, but not school-age asthma or reduced lung function [19]; airway microbiota and the candidate gene GSDMB (encoding gasdermin-B) might play a role in childhood asthma development [20,21]; and asthma-like symptoms in childhood were related to a doubled risk of COPD in adulthood [22]. In the symposium on current paediatric asthma guidelines, the evidence of the paradigm shift to recommend earlier treatment with as-needed lowdose corticosteroids in children with mild asthma, proposed by Global Initiative for Asthma (GINA), ERS International Congress 2020: highlights from best-abstract awardees was discussed by Dr Louise Fleming.…”

Section: Assembly 7: Paediatrics (Sara M Mensink-bout)mentioning

confidence: 99%

European Respiratory Society International Congress 2020: highlights from best-abstract awardees

Britton

Elbehairy

Mensink‐Bout

et al. 2020

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During the 2020 European Respiratory Society (ERS) International Congress, the author of the best abstract (highest average score of abstract reviewers and only those who had not applied or were not eligible for a sponsored award) of every Assembly was awarded “a best-abstract certificate”. Best-abstract awardees were invited to write a short summary about their virtual Congress experience and their view on the evolving field of research in light of their respective ERS Assembly. The purpose of this article is to give the readers a quick overview of some of the Congress highlights and to give the stage to the promising best-abstract awardees as they are the future of the ERS.

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“…No studies have directly examined whether RSV bronchiolitis in infancy leads to an increased risk of adult respiratory disease. However, results of long-term cohort studies show associations between childhood infection and wheezy episodes and a “persistently low lung function” trajectory through adult life [ 1 , 2 ], and between “asthma-like symptoms” in early childhood and the development of COPD in later life [ 23 ].…”

Section: Does Rsv Bronchiolitis Increase the Risk Of Respiratory Illness Through The Life Course?mentioning

confidence: 99%

Palivizumab immunoprophylaxis for infants with BPD has medium- and long-term benefits: myth or maxim?

Quinn

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Williams

et al. 2021

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Asthma-like symptoms in young children increase the risk of COPD

Cited by 21 publications

References 33 publications

Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

Impact of early life exposures on COPD in adulthood: A systematic review and meta‐analysis

European Respiratory Society International Congress 2020: highlights from best-abstract awardees

Palivizumab immunoprophylaxis for infants with BPD has medium- and long-term benefits: myth or maxim?

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