Asthma hospitalization patterns in young children relating to admission age, infection presence, sex, and race

Lin, Robert Y.; Pitt, Tracy; Lou, Wendy; Yi, Qilong

doi:10.1016/s1081-1206(10)60686-2

Cited by 18 publications

(18 citation statements)

References 16 publications

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“…For comparison, the average summer scaling value for asthma hospitalizations for children aged 0–4 years in New York State from 1990 to 2004 was calculated to be 0.138. 35 The comparable summer asthma hospitalizations for all ages—including adults— from 2000 to 2005 in New York State was 0.173; these comparisons suggest that the scaling factor used was reasonable.…”

Section: Methodsmentioning

confidence: 89%

Modeling of Regional Climate Change Effects on Ground-Level Ozone and Childhood Asthma

Sheffield¹,

Knowlton²,

Carr³

et al. 2011

American Journal of Preventive Medicine

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Background The adverse respiratory effects of ground-level ozone are well-established. Ozone is the air pollutant most consistently projected to increase under future climate change. Purpose To project future pediatric asthma emergency department visits associated with ground-level ozone changes, comparing 1990s to 2020s. Methods This study assessed future numbers of asthma emergency department visits for children aged 0–17 years using (1) baseline New York City metropolitan area emergency department rates, (2) a dose–response relationship between ozone levels and pediatric asthma emergency department visits, and (3) projected daily 8-hour maximum ozone concentrations for the 2020s as simulated by a global-to-regional climate change and atmospheric chemistry model. Sensitivity analyses included population projections and ozone precursor changes. This analysis occurred in 2010. Results In this model, climate change could cause an increase in regional summer ozone-related asthma emergency department visits for children aged 0–17 years of 7.3% across the New York City metropolitan region by the 2020s. This effect diminished with inclusion of ozone precursor changes. When population growth is included, the projections of morbidity related to ozone are even larger. Conclusions The results of this analysis demonstrate that the use of regional climate and atmospheric chemistry models make possible the projection of local climate change health effects for specific age groups and specific disease outcomes – such as emergency department visits for asthma. Efforts should be made to improve on this type of modeling to inform local and wider-scale climate change mitigation and adaptation policy.

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Section: Methodsmentioning

confidence: 89%

Modeling of Regional Climate Change Effects on Ground-Level Ozone and Childhood Asthma

Sheffield¹,

Knowlton²,

Carr³

et al. 2011

American Journal of Preventive Medicine

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“…This result was expected because the relationships among these measures are not fixed early in childhood, especially before age 5 or 6 years (Martinez 2002). Transient wheeze often due to viral infection is common in infancy (Brooks and Lemanske 2002; Lin et al, 2007) and may not predict persistent asthma later in childhood. Atopy also becomes more strongly associated with persistent asthma at older ages (Martinez 2002).…”

Section: Discussionmentioning

confidence: 99%

Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City children

Patel

Quinn

Jung

et al. 2011

Environmental Research

113

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Exposures to ambient air traffic-related pollutants and their sources have been associated with respiratory and asthma morbidity in children. However, longitudinal investigation of the effects of traffic-related exposures during early childhood is limited. We examined associations of residential proximity and density of traffic and stationary sources of air pollution with wheeze, asthma, and immunoglobulin (Ig) E among New York City children between birth and age 5 years. Subjects included 593 Dominican and African American participants from the Columbia Center for Children’s Environmental Health cohort. Prenatally, through age 5 years, residential and respiratory health data were collected every 3-6 months. At ages 2, 3, and 5 years, serum IgE was measured. Spatial data on the proximity and density of roadways and built environment were collected for a 250 meter buffer around subjects’ homes. Associations of wheeze, asthma, total IgE, and allergen-specific IgE with prenatal, earlier childhood, and concurrent exposures to air pollution sources were analyzed using generalized estimating equations or logistic regression. In repeated measures analyses, concurrent residential density of four-way intersections was associated significantly with wheeze (odds ratio: 1.26; 95% confidence interval [CI]: 1.01, 1.57). Age 1 exposures also were associated with wheeze at subsequent ages. Concurrent proximity to highway was associated more strongly with total IgE (ratio of the geometric mean levels: 1.25; 95% CI: 1.09, 1.42) than were prenatal or earlier childhood exposures. Positive associations also were observed between percent commercial building area and asthma, wheeze, and IgE and between proximity to stationary sources of air pollution and asthma. Longitudinal investigation suggests that among Dominican and African American children living in Northern Manhattan and South Bronx during ages 0 to 5 years, residence in neighborhoods with high density of traffic and industrial facilities may contribute to chronic respiratory morbidity, and concurrent, prenatal, and earlier childhood exposures may be important. These findings may have broad implications for other urban populations that commonly have high asthma prevalence and exposure to a high density of traffic and stationary air pollution sources.

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“…Autumn peaks of asthma-related exacerbations have been well described. [1][2][3][4][5] Several investigators have shown that the increase in ED visits and hospitalizations in early fall is closely associated with return to school after summer vacation. 4,7,8 Using Canadian asthma hospital admission data from 1990 to 2002, Johnston et al 8 applied mathematical modeling to estimate the exact timing and magnitude of September asthma hospitalization epidemics in children and adults.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] This peak in asthma-related events appears to be associated with an increase in viral respiratory infections, especially rhinovirus, and the start of the school year. 3,7,8 Although studies have been conducted worldwide, the Ontario study has been one of the most detailed examinations of both the prevalence and potential casual factors of the fall asthma epidemic.…”

mentioning

confidence: 99%

Dispensing of fluticasone propionate/salmeterol combination in the summer and asthma-related outcomes in the fall

Spahn

Sheth²,

Yeh

et al. 2009

Journal of Allergy and Clinical Immunology

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Asthma hospitalization patterns in young children relating to admission age, infection presence, sex, and race

Cited by 18 publications

References 16 publications

Modeling of Regional Climate Change Effects on Ground-Level Ozone and Childhood Asthma

Modeling of Regional Climate Change Effects on Ground-Level Ozone and Childhood Asthma

Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City children

Dispensing of fluticasone propionate/salmeterol combination in the summer and asthma-related outcomes in the fall

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