Asthma: from childhood to adulthood

Grol, MH; Gerritsen, Jorrit; Postma, D.S.

doi:10.1111/j.1398-9995.1996.tb04485.x

Cited by 39 publications

(4 citation statements)

References 103 publications

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“…Studies of the natural history of asthma consistently find that female sex, atopy, and airway hyperresponsiveness are associated with the persistence of asthma from childhood to adulthood (2,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). However, studies are conflicting regarding risk factors for predicting new asthma or wheeze during adolescence.…”

mentioning

confidence: 99%

Sex Differences in Factors Associated with Childhood- and Adolescent-Onset Wheeze

Mandhane

Greene

Cowan

et al. 2005

Am J Respir Crit Care Med

127

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Rationale: Factors predicting the development of wheeze may differ between sexes and between childhood and adolescence. Methods: A New Zealand birth cohort of 1,037 children was followed to age 26. For this analysis, those reporting recurrent wheezing at two or more assessments were classified as "wheezers." We examined risk factors for development of wheeze before age 10 (childhood) and subsequently (adolescent-onset) for males and for females separately using Cox regression modeling. Results: Males more often developed childhood wheeze (p ϭ 0.002) and females adolescentonset wheeze (p Ͻ 0.001). Maternal atopy (asthma or hay fever) was a risk factor for childhood wheeze in both sexes (hazard ratio [HR], 1.48, p Ͻ 0.05 for males; HR, 2.37, p Ͻ 0.001 for females). Paternal atopy also influenced childhood wheeze, significantly for males (HR, 1.72; p ϭ 0.01), and similarly but not significantly for females (HR, 1.70; p ϭ 0.08). For adolescent-onset wheeze, neither maternal (HR, 1.41; p ϭ 0.19) nor paternal history (HR, 0.73; p ϭ 0.42) was a risk factor in males, but maternal history (HR, 2.08; p Ͻ 0.01) was a significant risk factor for females. When both age ranges were combined, providing greater power for analysis, paternal history was a stronger risk factor for wheeze in females (HR, 1.62; p ϭ 0.02) than in males (HR, 1.35; p ϭ 0.12). Conclusion: The influence of parental atopy on the development for wheeze differs between males and females and between childhood-and adolescent-onset wheeze.

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mentioning

confidence: 99%

Sex Differences in Factors Associated with Childhood- and Adolescent-Onset Wheeze

Mandhane

Greene

Cowan

et al. 2005

Am J Respir Crit Care Med

127

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“…This is especially the case in young children or in adult populations where spirometry is not feasible, as the FOT does not require a learned manoeuvre [1][2][3][4][5].…”

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confidence: 99%

Airway resistance variability and response to bronchodilator in children with asthma

Lall¹,

Cheng²,

Hernández³

et al. 2007

European Respiratory Journal

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Variability of airway function is a feature of asthma, spanning timescales from months to seconds. Short-term variation in airway resistance (Rrs) is elevated in asthma and is thought to be due to increased variation in the contractile activation of airway smooth muscle. If true, then variation in Rrs should decrease in response to bronchodilators, but this has not been investigated.Using the forced oscillation technique, Rrs and the variation in Rrs from 4-34 Hz were measured in 39 children with well-controlled mild-to-moderate asthma and 31 healthy controls (7-13 yrs) before and after an inhaled bronchodilator (200 mg salbutamol) or placebo.In agreement with other findings, baseline Rrs at all frequencies and the SD of Rrs (Rrs SD) below 14 Hz were found to be elevated in asthma while neither forced expiratory volume in one second nor the mean forced expiratory flow between 25 and 75% of forced vital capacity were different compared with controls. The present authors found that Rrs SD changed the most of any measurement in asthma, and this was the only measurement that changed significantly more in children with asthma following bronchodilator administration.The present results show that like airway narrowing, short-term airway variability of resistance may be a characteristic feature of asthma that may be useful for monitoring response to therapy.

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“…The majority of children with asthma experience clinical remission and are symptom-free by early adulthood (7). Nonetheless, those with remitted child-onset asthma have basement membrane thickening on endobronchial biopsy and relatively few have completely normal lung function at age 18–25 years old (8).…”

Section: Introductionmentioning

confidence: 99%

Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

Donohue

Hoffman

Baumhauer

et al. 2013

Journal of Allergy and Clinical Immunology

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Background The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort. Objective The authors hypothesized that a history of asthma onset in childhood (age 18 or before) or young adulthood (age 19 to 45) was associated with altered lung structure on computed tomography (CT) in later life. Methods The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3,965 participants and assessed asthma history using standardized questionnaires, spirometry following guidelines, and segmental airway dimensions and percent low attenuation areas on CT scans. Results Asthma with onset in childhood and young adulthood was associated with large decrements in the forced expiratory volume in one second among participants with a mean age of 66 years (−365 ml and −343 ml, respectively; P<0.001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (Pi10) (0.1 mm, P<0.001 for both), predominantly from narrower segmental airway lumens (−0.39 mm and −0.34 mm, respectively; P<0.001). Asthma with onset in childhood and young adulthood also was associated with a greater percentage of low attenuation areas (1.69% and 4.30%, respectively; P<0.001). Findings were similar among never smokers except that differential percentage of low attenuation areas in child-onset asthma was not seen in them. Conclusion Asthma with onset in childhood or young adulthood, was associated with reduced lung function, narrower airways and, among asthmatics who smoked, greater percentage of low attenuation areas in later life.

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Asthma: from childhood to adulthood

Cited by 39 publications

References 103 publications

Sex Differences in Factors Associated with Childhood- and Adolescent-Onset Wheeze

Sex Differences in Factors Associated with Childhood- and Adolescent-Onset Wheeze

Airway resistance variability and response to bronchodilator in children with asthma

Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

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