Asthma epidemiology: has the crisis passed?

Lawson, Joshua

doi:10.1097/01.mcp.0000147861.60768.24

Cited by 33 publications

(18 citation statements)

References 34 publications

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“…These results are in keeping with other reports of diagnostic exchange (Burney et al 1990;Dodge et al 1986;Fletcher 1978;Lundback et al 2001;Tinkelman et al 2006). Our finding of stabilized rates of asthma prevalence in more recent years has also been observed by others (Lawson and Senthilselvan 2005).…”

Section: Figure 2 Prevalence Of Respiratory Diseases Over Time Agessupporting

confidence: 83%

“…n Manitoba, as in Canada and elsewhere, many studies have reported increasing rates of asthma prevalence over time, especially among children (Akinbami and Schoendorf 2002;Burney et al 1990;Erzen et al 1995;Garner and Kohen 2008;Kozyrskyj and Hildes-Ripstein 2002;Kozyrskyj et al 2004;Lawson and Senthilselvan 2005;Lundback et al 2001;Manfreda et al 1993;Mannino et al 2002;Millar and Hill 1998;Moorman et al 2007;Senthilselvan et al 2003;Senthilselvan 1998). This "asthma epidemic" has raised concern among clinicians, researchers, policy makers and the public, sparking new studies to understand the causes of this increase.…”

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confidence: 99%

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The Rising Prevalence of Asthma: True Increase, Diagnostic Exchange or Diagnostic Accuracy?

Fransoo

Martens²,

Prior³

et al. 2013

hcpol

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In the midst of frequent reports about "the asthma epidemic," results from a number of studies by the Manitoba Centre for Health Policy have shown stable or decreasing prevalence of an overall indicator of respiratory diseases which includes asthma. To resolve these apparently contrary findings, we conducted a time trend analysis using administrative data. Results revealed significant potential for diagnostic exchange: asthma prevalence increased, but that of bronchitis decreased. RésuméDans le contexte des fréquents rapports indiquant une « épidémie d' asthme », les résultats de plusieurs études effectuées par le Centre des politiques de santé du Manitoba montrent une prévalence stable ou en déclin d'un indicateur global des maladies respiratoires, y compris l' asthme. Afin de résoudre la contradiction apparente de ces résultats, nous avons effectué une analyse évolutive des tendances au moyen de données administratives. Les résultats révèlent une forte possibilité de substitution de diagnostic : la prévalence de l' asthme a augmenté, mais celle de la bronchite a diminué.

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Section: Figure 2 Prevalence Of Respiratory Diseases Over Time Agessupporting

confidence: 83%

mentioning

confidence: 99%

The Rising Prevalence of Asthma: True Increase, Diagnostic Exchange or Diagnostic Accuracy?

Fransoo

Martens²,

Prior³

et al. 2013

hcpol

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“…While recent data suggest that the trend of prevalence, at least for asthma, may be reaching a plateau, the number of patients with other allergic disorders such as rhinitis, urticaria and food and drug allergy is expected to continue to rise [1]. Anaphylaxis is the most dramatic clinical presentation of allergy and is frequently a medical emergency in both paediatric and adult patients [2].…”

Section: Introductionmentioning

confidence: 99%

Allergy and the cardiovascular system

Triggiani

Patella²,

Staiano

et al. 2008

Clinical and Experimental Immunology

154

147

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SummaryThe most dangerous and life-threatening manifestation of allergic diseases is anaphylaxis, a condition in which the cardiovascular system is responsible for the majority of clinical symptoms and for potentially fatal outcome. The heart is both a source and a target of chemical mediators released during allergic reactions. Mast cells are abundant in the human heart, where they are located predominantly around the adventitia of large coronary arteries and in close contact with the small intramural vessels. Cardiac mast cells can be activated by a variety of stimuli including allergens, complement factors, general anesthetics and muscle relaxants. Mediators released from immunologically activated human heart mast cells strongly influence ventricular function, cardiac rhythm and coronary artery tone. Histamine, cysteinyl leukotrienes and platelet-activating factor (PAF) exert negative inotropic effects and induce myocardial depression that contribute significantly to the pathogenesis of anaphylactic shock. Moreover, cardiac mast cells release chymase and renin that activates the angiotensin system locally, which further induces arteriolar vasoconstriction. The number and density of cardiac mast cells is increased in patients with ischaemic heart disease and dilated cardiomyopathies. This observation may help explain why these conditions are major risk factors for fatal anaphylaxis. A better understanding of the mechanisms involved in cardiac mast cell activation may lead to an improvement in prevention and treatment of systemic anaphylaxis.

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“…Studies from around the world suggest that the incidence and prevalence of asthma began to increase more than two decades ago, with no sign that these disturbing trends may be reversing [1]. Asthma is characterized by episodic dyspnea, airway obstruction, mucus cell metaplasia and T-helper cell type 2 (Th2)-dependent inflammation of the lung.…”

mentioning

confidence: 99%