Asthma: definitions and pathophysiology

Mims, James W.

doi:10.1002/alr.21609

Cited by 453 publications

(357 citation statements)

References 28 publications

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“…Asthma is an important and serious public health problem in many countries in the world. Asthma can be mild and doesn’t interfere with the activity, but it can also be persistent and disturbing [1–3]. Atopic asthma or allergic asthma is asthma based on allergic reaction to the acquisition properties of atopy that found in family and characterized by increased total immunoglobulin E (IgE) or specific IgE.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of asthma in Indonesia ranged between 5 and 7%, in global prevalence of asthma ranging from 7 to 10%. According to data from the Center for Diseases Control and Prevention (CDC) National Asthma Control Program in United States 2010 there were 18.7 million adults suffer from Asthma and about nine people die from asthma each day [1, 2, 4, 5]. The prevalence of atopic asthma between 70 and 80% of people with asthma, and about 70–80% of people with asthma also accompanied with allergic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

“…The development of science and technology in the world is not entirely followed by the progress treatment for asthma, this has been shown by the data from many countries which show that number of asthma visit in emergency department, hospitalizations, morbidity and even mortality had increased [5]. In the developed country asthma exacerbations usually is caused by a viral infection, this is different from developing countries that exacerbations are usually caused by bacteria [1, 6]. …”

Section: Introductionmentioning

confidence: 99%

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Expression of mRNA IL-17F and sIL-17F in atopic asthma patients

et al. 2017

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BackgroundAsthma is a chronic inflammatory disorder of airway that involves many cells and elements. Chronic inflammation caused by increase Airway hyperresponsiveness that cause recurrent episodic symptoms of breathlessness, wheezing, chest tightness and coughing, especially at night or early morning. Interleukin 17F is a cytokine that plays an important role in the pathophysiology of asthma attacks. Some studies show a variety of IL-17F roles in the pathogenesis of airway inflammation due to an allergic reaction.ResultsThe study was conducted at the Prof. Dr. R. D. Kandou Manado Hospital, Indonesia. Samples were taken continuously until the number of meant samples was achieved. Blood samples were collected from 40 atopic asthmatic patients. From statistical analysis based on the hypothesis, there was positive correlation between mRNA levels of IL-17F and IL-17F in atopic asthmatic patient (p = 0.000 and r = 0.988).ConclusionsAccording these data suggest that levels of mRNA IL-17F and IL17F might be useful parameters for the diagnosis of atopic asthma patient.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of mRNA IL-17F and sIL-17F in atopic asthma patients

et al. 2017

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“…Asthma is a chronic inflammatory disorder of the airways [30,31]. Our study demonstrated that the level of oxidative stress was increased in mice both immunized and challenged with APE exposed to diesel exhaust, as represented by increased 3-NT expression, resulting in the nitration of various proteins, which enhanced oxidative stress, and provoked activation of NF-κB and production of more inflammatory cytokines and more serious immune imbalance.…”

Section: Discussionmentioning

confidence: 65%

Artemisia Pollen Extracts Exposed to Diesel Exhaust Enhance Airway Inflammation and Immunological Imbalance in Asthmatic Mice Model

Chen

Han

Zhou

et al. 2020

Int Arch Allergy Immunol

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Background: Vehicle-induced air pollution may increase the prevalence and severity of asthma. Pollens are important sources of outdoor allergens associated with asthma. Outdoor pollution may influence the structure of pollen grains, resulting in enhanced immune reactions. Objective: This study aims to investigate the impact that artemisia pollen extracts exposed to diesel emissions (APEDE) may induceallergic airway inflammation, pulmonary pathology and immune imbalance -in mice. Methods: Sixty male Balb/c mice were equally randomized into 5 groups, sensitized with 30 μL artemisia pollen extracts (APE) or APEDE adsorbed on 2 mg aluminum hydroxide gel by intraperitoneal injection on day 0, 7, 14, and 22, and challenged intranasally once per day with 30 μL APE or APEDE from day 29 to 36. The control-ling group used phosphate-buffered saline as control. Results: In mice immunized and challenged by APEDE, the clinical phenotype of eosinophils, neutrophils in bronchoalveolar lavage fluid (BALF), tracheal wall thickness, airway smooth muscle thickness and airway resistance increased significantly. Pathophysiological parameters such as interleukin (IL)-17A and tumour necrosis factor-α production in BALF and serum, and the ratio of Th17/Treg cells in CD4 + cells increased significantly, while IL-10 in BALF and serum and the ratio of Treg cells decreased significantly. It was further found that the expression of oxidative stress marker 3-nitrotyrosine (3-NT) and the activation of nuclear factor kappa B (NF-κB) were significantly increased. The correlation analysis showed that the expression of 3-NT was positively correlated with the activation of NF-κB. Conclusion: Our findings suggested that pollens exposed to diesel exhaust enhance allergic responses, which may contribute to an increased prevalence of allergic diseases in urban environments with serious exhaust emissions.

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“…These symptoms are typically aggravated by certain environmental triggers, such as smoking, house dust mites, moulds, insects and other animals, pollens, foods, and drugs. 1 In addition to the cardinal symptoms, there are other diagnostic criteria for adult asthma. These include a positive family history of asthma or other allergic diseases, presence of other concurrent allergic diseases, improvement of asthma symptoms after taking asthma medications, as well as the presence of chest wheeze detected by a physician in clinic.…”

Section: Introductionmentioning

confidence: 99%