Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma

Rolfes, Mary; Juhn, Young J.; Wi, Chung‐Il; Sheen, Youn Ho

doi:10.4046/trd.2017.80.2.113

Cited by 23 publications

(17 citation statements)

References 158 publications

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“…However, we did not find all expected connections, especially for drugs for cardiovascular diseases, probably because of their wide range of use and the rather high socioeconomic status of our population of elderly women [31]. Interestingly, our study supports the relationship between asthma and rheumatism/inflammation, which might have some implications in the management of these patients by considering leukotriene receptor antagonists as a therapeutic option [32].…”

Section: Discussionmentioning

confidence: 51%

Multimorbidity medications and poor asthma prognosis

Chanoine

Sanchez

et al. 2018

Eur Respir J

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Multimedication related to multimorbidity is common in the elderly with asthma. We aimed at comprehensively characterising medications used by elderly women and assessing how multimedication impacts on asthma prognosis.We performed network-based analyses on drug administrative databases to visualise the prevalence of drug classes and their interconnections among 17 458 elderly women from the Asthma-E3N study, including 4328 women with asthma. Asthma groups sharing similar medication profiles were identified by a clustering method relying on all medications and were studied in association with adverse asthma events (uncontrolled asthma, attacks/exacerbations and poor asthma-related quality of life).The network-based analysis showed more multimedication in women with asthma than in those without asthma. The clustering method identified three multimedication profiles in asthma: "Few multimorbidity-related medications" (43.5%), "Predominantly allergic multimorbidity-related medications" (32.8%) and "Predominantly metabolic multimorbidity-related medications" (23.7%). Compared with women belonging to the "Few multimorbidity-related medications" profile, women belonging to the two other profiles had an increased risk of uncontrolled asthma and asthma attacks/exacerbations, and had lower asthma-related quality of life.The integrative data-driven approach on drug administrative databases identified specific multimorbidity-related medication profiles that were associated with poor asthma prognosis. These findings support the importance of multimorbidity in the unmet needs in asthma management.

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Section: Discussionmentioning

confidence: 51%

Multimorbidity medications and poor asthma prognosis

Chanoine

Sanchez

et al. 2018

Eur Respir J

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“…The co-existence of asthma with chronic obstructive pulmonary disease may also partly explain the association between asthma and diabetes and mental disorders. Asthma has also been shown to be a risk factor of developing rheumatoid arthritis (42), but more studies are needed to explore its association with osteoarthritis. The relationships of osteoarthritis with cardiometabolic and mental disorders have been observed in many studies (28,43), but the association between osteoarthritis and cancer is not clear.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Progression, and Patterns of Multimorbidity in Community-Dwelling Middle-Aged Men and Women

Shang

Peng

Hill

et al. 2020

Front. Public Health

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Background: Determining the incidence, progression, and patterns of multimorbidity are important for the prevention, management, and treatment of concurrence of multiple conditions. This study aimed to analyze major multimorbidity patterns and the association of the onset of a primary condition or combinations of a primary and a secondary condition with the progression to subsequent conditions. Methods: We included 53,867 participants aged 45-64 years from the 45 and Up Study who were free of 10 predefined chronic conditions at baseline (2006-2009). The incidence of multimorbidity (coexistence of ≥2, ≥3, and ≥4 conditions) was identified using the claims database until December 31, 2016. The primary, secondary, tertiary, and quaternary condition for each participant was defined according to its temporal order of onset. Results: During a mean 9-years follow-up, the cumulative incidence of primary, secondary, tertiary, and quaternary conditions was 49.6, 23.7, 9.0, and 2.9%, respectively. The time to develop a subsequent condition decreased with the accumulation of conditions (P < 0.0001). Two concurrent cardiometabolic disorders (CMDs, 30.4%) and CMDs clustered with musculoskeletal disorders (15.2%), mental disorders (13.5%), asthma (12.0%), or cancer (8.7%) were the five most common multimorbidity patterns. CMDs tended to occur prior to mental or musculoskeletal disorders but after the onset of cancers or asthma. Compared with all participants who developed cancer as a primary condition, individuals who experienced mental disorders/neurodegenerative disorders and a comorbidity as cardiovascular disease, hypertension, dyslipidemia, diabetes, asthma, or osteoarthritis were 3.36-10.87 times more likely to develop cancer as a tertiary condition. Individuals with neurodegenerative disorders and a comorbidity as hypertension, dyslipidemia, osteoarthritis, or asthma were 5.14-14.15 times more likely to develop mental disorders as a tertiary condition. Shang et al. Incidence, Progression, Patterns of Multimorbidity Conclusions: A high incidence of multimorbidity in middle-aged adults was observed and CMDs were most commonly seen in multimorbidity patterns. There may be accelerated aging after a primary condition occurs. Our findings also reveal a potential preventative window to obviate the development of secondary or tertiary conditions.

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“…With regard to positive association, a Finnish cohort study has indicated that the cumulative incidence of asthma in children with coeliac disease or RA was significantly higher than in children without coeliac disease or RA, concluding that Th1 and Th2 diseases could indeed coexist [ 16 ]. Furthermore, a review on the relationship between asthma and RA [ 17 ] and a study between asthma and proinflammatory conditions [ 18 ], done by the Mayo Medical School of Rochester, USA, pointed out that although a population-based cohort study is required utilizing a well-defined population, the standing evidence from these studies found through the review is quite convincing and strongly supports the positive association between asthma and the risk of RA. Conversely, a study done in Germany stated an opposing result supporting that there exists an inverse association between Th1 and Th2 diseases, where RA and atopy antagonize each other and that a change in the cytokine patterns of Th1 and Th2 cells could provide an indication for curative effect on RA [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several previous studies have suggested few potential mechanisms underlying the positive association present between respiratory allergic diseases and the increased risk of prevalence of RA [ 17 ]. Possible mechanisms are genetic, environmental factors, natural killer group 2D (NKG2D), and tumor necrosis factor alpha (TNF-alpha).…”

Section: Discussionmentioning

confidence: 99%

Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study

Jeong

Jung

Cho

2018

International Journal of Rheumatology

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Rheumatoid arthritis (RA) and allergic diseases are result of a poor functioning immune system, giving dominance to either T-helper 1 (Th1) or T-helper 2 (Th2) diseases, respectively. Studies have stated that there seems to be a relationship present between the immune response subsets. This study was designed to examine the association between RA and respiratory allergic diseases in Korean adults. The study utilized the KNHANES 2013–2015 data and excluded individuals diagnosed with RA before being diagnosed with allergic diseases, using age at clinical diagnosis. Total of 253 RA patients were matched 1 : 1 with non-RA patients by a propensity score, using sex and age as matched variables. Multivariate conditional logistic regression analyses were used to evaluate for association between RA and respiratory allergic diseases in the matched 506 participants. RA was associated with an increased risk of prevalence of respiratory allergic diseases with an OR of 1.51 (95% CI, 1.31–1.75), adjusted for socioeconomic demographic variables. The adjusted OR for prevalence of RA among participants with prevalence of asthma and allergic rhinitis was as follows: 3.12 (95% CI, 2.77–3.51) and 1.39 (95% CI, 1.16–1.67). Participants with prevalence of asthma in particular had an increased risk of developing prevalence of RA. Based on our findings, Th1 and Th2 diseases may indeed coexist, and one pathway may stimulate or contribute towards the onset of the other.

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Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma

Cited by 23 publications

References 158 publications

Multimorbidity medications and poor asthma prognosis

Multimorbidity medications and poor asthma prognosis

Incidence, Progression, and Patterns of Multimorbidity in Community-Dwelling Middle-Aged Men and Women

Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study

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