Asthma and pulmonary embolism: bringing airways and vessels closer together

Konstantinides, Stavros

doi:10.1183/09031936.00009414

Cited by 5 publications

(4 citation statements)

References 21 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study by BØRVIK et al [16] is in accordance with these data reporting a higher pulmonary embolism incidence rate in COPD patients (2.7 per 1000 personyears, 41 events in 15 446 person-years) compared with non-COPD patients (1.6 per 1000 person-years, 68 events in 41 744 person-years). Further evidence in line with these observations, although less pronounced, is provided by recent studies demonstrating a higher incidence of pulmonary embolism in patients with asthma: In 31 356 asthma patients from Taiwan's National Health Insurance Research Database, the incidence of pulmonary embolism was higher (0.10 per 1000 person-years) compared with 125 157 individuals without asthma (0.03 per 1000 person-years; HR 3.24, 95% CI 1.74-6.01) [28,29]. Additionally, the incidence of pulmonary embolism was higher in Dutch patients with severe asthma (0.93 per 1000 person-years) compared with mild-to-moderate asthma (0.33 per 1000 person-years) and a general population in Norway (0.18 per 1000 person-years) [30].…”

mentioning

confidence: 90%

Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

Lankeit

Held

2016

Eur Respir J

View full text Add to dashboard Cite

mentioning

confidence: 90%

Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

Lankeit

Held

2016

Eur Respir J

View full text Add to dashboard Cite

“…Further deterioration of the respiratory lesions of SS may lead to progressive changes such as airway obstruction [6] , [28] , [29] , alveolitis [24] , [30] , pulmonary lymphoma [20] , interstitial fibrosis [20] , vasculitis [13] , or pulmonary arterial hypertension [17] , [18] . This indicates a positive association of SS with the airways, alveoli, interstitia, and vessels of the lung, which in turn may contribute to the incidence of RF, even without comorbidities [28] , [31] , [32] .…”

Section: Discussionmentioning

confidence: 93%

Association between Sjogren's Syndrome and Respiratory Failure: Put Airway, Interstitia, and Vessels Close Together: A National Cohort Study

Yeh

Chen

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

ObjectivesFew studies have evaluated the association between Sjogren's syndrome (SS) and respiratory failure (RF). Thus, we conducted a retrospective national cohort study to investigate whether Sjogren's syndrome (SS) increases the risk of respiratory failure (RF).MethodsThe cohort consisted of 4954 newly diagnosed patients with SS but without a previous diagnosis of RF, and 19816 patients as the comparison cohort from the catastrophic illnesses registry, obtained from the 2000–2005 period. All of the study participants were followed from the index date to December 31, 2011. We analyzed the association between the risk of RF and SS by using a Cox proportional hazards regression model, controlling for sex, age, and comorbidities.ResultsThe overall incidence rate of RF showed a 3.21-fold increase in the SS cohort compared with the comparison cohort. The adjusted HR of RF was 3.04 for the SS cohort compared with the comparison cohort, after we adjusted for sex, age, and comorbidities. The HRs of RF for patients with primary SS and secondary SS compared with the comparison cohort were 2.99 and 3.93, respectively (P for trend <.001). The HRs of RF increased as the severity of SS increased, from 2.34 for those with no inpatient care experience to 5.15 for those with inpatient care experience (P for trend <.001).ConclusionThis study indicates that clinical physicians should not only consider secondary SS but also primary SS as a critical factor that increases the risk of RF.

show abstract

“…29 Other studies in nonobstetric patients have demonstrated increased risk for venous thromboembolism among patients with asthma with risk highest among patients with frequent exacerbations and hospitalizations. [30][31][32] Studies have demonstrated that asthma is associated with increased prothrombotic factors and endothelial dysfunction leading to atherothrombosis and pulmonary embolism. 30 Although attributable risk for venous thromboembolism among deliveries with asthma is low, further investigation is indicated to determine to what degree asthma is a meaningful risk factor for this complication.…”

Section: Discussionmentioning

confidence: 99%

Trends in and Maternal Outcomes of Delivery Hospitalizations of Patients With an Asthma Diagnosis

Friedman¹,

DiMango²,

Guglielminotti³

et al. 2021

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Financial DisclosureDr. D'Alton had a senior leadership role in ACOG II's Safe Motherhood Initiative, which received unrestricted funding from Merck for Mothers. Dr. Wright disclosed that he received royalties from UpToDate for writing/review of chapters related to cervical dysplasia, human papillomavirus, and cervical cancer. He served as a consultant for Clovis Oncology and participated in their advisory board (March 2019). He performed medicolegal review of malpractice cases related to delayed diagnosis of gynecologic cancer and intraoperative complications during gynecologic surgery. He is currently serving on the SGO Board of Directors (no monetary compensation) from 2019 to 2022. He conducted epidemiologic research trials examining patterns of care for ovarian, uterine, and cervical cancer for Merck. Lastly, he has also performed analysis of and provided education on clinical trials data for Otsuka Pharmacovigilance. The other authors did not report any potential conflicts of interest.

show abstract

Asthma and pulmonary embolism: bringing airways and vessels closer together

Cited by 5 publications

References 21 publications

Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

Association between Sjogren's Syndrome and Respiratory Failure: Put Airway, Interstitia, and Vessels Close Together: A National Cohort Study

Trends in and Maternal Outcomes of Delivery Hospitalizations of Patients With an Asthma Diagnosis

Contact Info

Product

Resources

About