Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

Lankeit, Mareike; Held, Matthias

doi:10.1183/13993003.01679-2015

Cited by 21 publications

(17 citation statements)

References 28 publications

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“…). Although findings of the incidence of pulmonary embolism in COPD vary and may depend on geographical location (Lankeit & Held, ), a single‐centre prospective study found that 29% of COPD patients hospitalized for acute exacerbation had pulmonary embolism (Akpinar et al . ).…”

Section: Introductionmentioning

confidence: 99%

Intrapulmonary arteriovenous anastomoses in humans with chronic obstructive pulmonary disease: implications for cryptogenic stroke?

Norris

Mangum

Kern

et al. 2016

Experimental Physiology

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New Findings r What is the central question of this study? Do individuals with chronic obstructive pulmonary disease have blood flow through intrapulmonary arteriovenous anastomoses at rest or during exercise? r What is the main finding and its importance?Individuals with chronic obstructive pulmonary disease have a greater prevalence of blood flow through intrapulmonary arteriovenous anastomoses at rest than age-matched control subjects. Given that the intrapulmonary arteriovenous anastomoses are large enough to permit venous emboli to pass into the arterial circulation, patients with chronic obstructive pulmonary disease and an elevated risk of thrombus formation may be at risk of intrapulmonary arteriovenous anastomosis-facilitated embolic injury (e.g. stroke or transient ischaemic attack).The pulmonary capillaries prevent stroke by filtering venous emboli from the circulation. Intrapulmonary arteriovenous anastomoses are large-diameter (ࣙ50 µm) vascular connections in the lung that may compromise the integrity of the pulmonary capillary filter and have recently been linked to cryptogenic stroke and transient ischaemic attack. Prothrombotic populations, such as individuals with chronic obstructive pulmonary disease (COPD), may be at increased risk of stroke and transient ischaemic attack facilitated by intrapulmonary arteriovenous anastomoses, but the prevalence and degree of blood flow through intrapulmonary arteriovenous anastomoses in this population has not been fully examined and compared with age-matched healthy control subjects. We used saline contrast echocardiography to assess blood flow through intrapulmonary arteriovenous anastomoses at rest (n = 29 COPD and 19 control subjects) and during exercise (n = 10 COPD and 10 control subjects) in subjects with COPD and age-matched healthy control subjects. Blood flow through intrapulmonary arteriovenous anastomoses was detected in 23% of subjects with COPD at rest and was significantly higher compared with age-matched healthy control subjects. Blood flow through intrapulmonary arteriovenous anastomoses at rest was reduced or eliminated in subjects with COPD after breathing hyperoxic gas. Sixty per cent of subjects with COPD who did not have blood

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Section: Introductionmentioning

confidence: 99%

Intrapulmonary arteriovenous anastomoses in humans with chronic obstructive pulmonary disease: implications for cryptogenic stroke?

Norris

Mangum

Kern

et al. 2016

Experimental Physiology

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“…В ходе других исследований установлено, что ХОБЛ ассоциирована с более вы-соким риском развития гипертонии, атеросклероза, сердечной недостаточности, рака легких, остеопоро-за, метаболических расстройств, а вследствие этого, с более высоким риском смерти у данной категории больных [9,22,27,29,33]. В связи с этим выявление коморбидных заболеваний является важной частью анализа прогноза и исхода ХОБЛ.…”

Section: коморбидные заболевания как потенциальные клинические маркерunclassified

Difficulty of Copd Predicting as a Challenge to Modern Clinical Pulmonology

et al. 2016

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РезюмеВ последние годы современное медицинское сообщество пришло к выводу, что применяемые в настоящее время прогностические критерии течения ХОБЛ не позволяют с высокой достоверностью предсказать дальнейшее развитие заболевания, его осложнения и исходы. Наи-более востребованным прогностическим критерием в клинической практике по-прежнему остается определение уровня ОФВ 1 . Однако на-коплена достаточная доказательная база, делающая необходимым расширение списка критериев для определения более точного прогноза течения и клинического исхода заболевания. Ведущей задачей современной пульмонологии, становится поиск прогностических маркеров, комплекса нескольких параметров, способных обеспечить прогноз и своевременный выбор терапии. Одними из них могут стать наличие у больных ХОБЛ коморбидных заболеваний и высокой частоты обострений. Ключевые слова: ХОБЛ, прогностические критерии, ОФВ 1 , обострения, коморбидные заболевания. AbstractIn recent years, medical community has come to the conclusion that the currently used prognostic criteria of the course of COPD, do not allow to predict the further development of the disease, its complications and outcomes with high accuracy. The most popular predictor in clinical practice remains the determination of the level of FEV1. However, the need to expand the list of criteria for determination of a more precise prognosis and clinical outcome of the disease is obvious. The main task of modern pulmonology is the search for prognostic markers of several complex parameters, capable of ensuring the timely prognosis and choice of adequate therapy. The presence of comorbid diseases and high frequency of exacerbations in COPD patients should be treated as such markers.

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“…CXCL13 and IL-6 are both important pro-inflammatory factors (10,13). Research shows that the coagulation promoting effect of inflammation and vicious circle caused by the interaction of coagulationinflammation network have become important pathogenesis of thrombosis (14,15).…”

Section: Introductionmentioning

confidence: 99%

Changes in expression of serum chemokine CXCL13 and IL-6 after hip replacement, and the relationship with lower limb vein thrombus

Guan

2019

Exp Ther Med

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Changes in the expression of serum chemokine CXC ligand 13 (CXCL13) and interleukin-6 (IL-6), and the relationship with lower limb vein thrombus were explored. A total of 128 patients undergoing hip replacement in The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from May 2017 to June 2019 were selected, and the patients suffering from lower limb vein thrombus were enrolled as group A and other patients not suffering from it were enrolled as group B. Enzyme-linked immunosorbent assay was employed to determine the levels of serum chemokine CXCL13 and IL-6, and receiver operating characteristic curves of serum chemokine CXCL13 and IL-6 levels in diagnosing restenosis after surgery were drawn. Pearson's correlation coefficient was adopted to analyze the correlation between serum chemokine CXCL13 and IL-6, and the logistic regression analysis to analyze the risk factors affecting hip replacement in patients. The levels of serum CXCL13 and IL-6 in group A were significantly higher than those in group B (both P<0.001). The specificity and sensitivity of serum CXCL13 level in diagnosis of lower limb vein thrombus after hip replacement were 61.76 and 80.00%, respectively, and those of serum IL-6 level in diagnosis were 70.59 and 66.67%, respectively. Serum CXCL13 level was positively correlated with serum IL-6 level (P<0.001), and age, body mass index (BMI), CXCL13 level and IL-6 level of the patients were independent risk factors affecting the efficacy of hip replacement. Serum CXCL13 level and serum IL-6 level can be used as biological indexes for prediction of early lower limb vein thrombus after hip replacement, and logistic regression analysis revealed that the age of the patients, BMI, diabetes history, hyperlipidemia history, hypertension history, CXCL13 level and IL-6 level are independent risk factors affecting the efficacy of hip replacement.

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Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

Cited by 21 publications

References 28 publications

Intrapulmonary arteriovenous anastomoses in humans with chronic obstructive pulmonary disease: implications for cryptogenic stroke?

Intrapulmonary arteriovenous anastomoses in humans with chronic obstructive pulmonary disease: implications for cryptogenic stroke?

Difficulty of Copd Predicting as a Challenge to Modern Clinical Pulmonology

Changes in expression of serum chemokine CXCL13 and IL-6 after hip replacement, and the relationship with lower limb vein thrombus

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