Asterosaponins from the starfish Culcita novaeguineae and their bioactivities

Tang, Hai‐Feng; Yi, Yang‐Hua; Li, Ling; Sun, Peng; Zhang, San‐Qi; Yue-ping, Zhao

doi:10.1016/j.fitote.2005.07.009

Cited by 38 publications

(26 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on Nguyen's method for palladium-mediated β-selective glycosylation in the absence of a traditional C-2-ester neighboring group, [12,13] we used Pd(CH 3 CN) 4 -(BF 4 ) 2 to catalyze the glycosylation between disaccharide donor 2 and trisaccharide acceptor 14. The reactions were performed with 2 mol-% or 5 mol-% Pd(CH 3 CN) 4 (BF 4 ) 2 at different temperatures (Table 1, entries [1][2][3][4][5][6][7][8]. Unfortunately, in all cases, donor-derived decomposition products were isolated as the major products, and trisaccharide acceptor 14 remained almost unreacted.…”

Section: Synthesis Of Disaccharide Donormentioning

confidence: 99%

“…Steroidal glycosides, the predominant secondary metabolites in starfish, are considered to be responsible for the general toxicity of starfish, [1] and these steroidal glycosides show a broad spectrum of pharmacological activities. [2][3][4] The structures of steroidal glycosides seem to be quite peculiar in terms of both their carbohydrate and aglycon moieties. They are usually divided into three substructural types: asterosaponin (sulfated steroidal glycosides), steroidal cyclic glycosides, and polyhydroxysteroidal glycosides.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of the Pentasaccharide Moiety of Thornasterside A

Xiong

Ding

et al. 2013

Eur J Org Chem

View full text Add to dashboard Cite

Bacterial peptidoglycan is a mesh‐like network comprised of sugars and oligopeptides. Transpeptidases cross‐link peptidoglycan oligopeptides to provide vital cell wall rigidity and structural support. It was recently discovered that the same transpeptidases catalyze the metabolic incorporation of exogenous D‐amino acids onto bacterial cell surfaces with vast promiscuity for the side‐chain identity. It is now shown that this enzymatic promiscuity is not exclusive to side chains, but that C‐terminus variations can also be accommodated across a diverse range of bacteria. Atomic force microscopy analysis revealed that the incorporation of C‐terminus amidated D‐amino acids onto bacterial surfaces substantially reduced the cell wall stiffness. We exploited the promiscuity of bacterial transpeptidases to develop a novel assay for profiling different bacterial species.

show abstract

Section: Synthesis Of Disaccharide Donormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of the Pentasaccharide Moiety of Thornasterside A

Xiong

Ding

et al. 2013

Eur J Org Chem

View full text Add to dashboard Cite

show abstract

“…3B). (Okano et al, 1985;Pathirana and Anderson, 1986;Riccio et al, 1988;Tang et al, 2005). 최근에는 asterosaponin 화합물이 식물성장조절제로 서 기능이 있다는 연구결과가 보고되고 있으며 (Ishii et al, 2006(Ishii et al, , 2007 이를 활용한 농업용 퇴비개발에 대한 연구사례 가 있다 (Line, 1994 …”

Section: Open Access Research Articleunclassified

Aphicidal Activity of Starfish (Asterina pectinifera) Extracts against Green Peach Aphid (Myzus Persicae)

Jang¹,

Yi²,

Jung³

et al. 2011

Korean Journal of Environmental Agriculture

View full text Add to dashboard Cite

BACKGROUND: Starfish is one of major sea invertebrates that have become a serious economic threat to aquacultural farms in Korea. Much effort has sacrificed to reduce the economic losses of the farms by predatory starfish, including developing and searching biological resources for medicinal and agricultural purposes. In the present study, we investigated aphicidal activity of the extracts from the starfish Asterina pectinifera against green peach aphid. METHODS AND RESULTS: Fresh starfishes were cut into small pieces, homogenized and soaked in methanol. The methanol extracts were centrifuged and the resulting supernatant was subjected to aphicidal activity assays and a series of silica gel column chromatography. More than 70% mortality of aphids were observed by the extracts at a concentration of 1,000 mg/L, exhibiting dose-dependent mortality. TOF-MS analyses detected polyhydroxysteroid as a main aphicidal compound from the starfish extracts.Transmission electronic microscopy could demonstrate that the extracts with polyhydroxysteroid caused aphids death by affecting their epicuticular membrane.

show abstract

“…Diverse pharmacological effects induced by asterosaponin and its analogues have been reported, including antibacterial, antiviral, antitumor and antifungal activities (5)(6)(7). A previous study has demonstrated that asterosaponin 1 whose chemical structure is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

Zhao

Zhu²,

Li³

et al. 2011

Oncol Rep

View full text Add to dashboard Cite

Abstract. Asterosaponin 1, a new cytostatic agent from starfish, possesses several bioactivities including an antitumor effect. The aim of this study was to investigate the potential anti-proliferative and pro-apoptotic activity of asterosaponin 1 in A549 human lung cancer cells, as well as the potential mechanisms. The results showed that asterosaponin 1 inhibited the proliferation of A549 cells in a dose-dependent manner, and the cytostatic activity resulted from the induction of apoptotic cell death. Asterosaponin 1 increased ER dilation and cytosolic Ca 2+ concentration, and enhanced the expression of the ER molecular chaperones GRP78 and GRP94 in a doseand time-dependent manner. In addition, asterosaponin 1 treated A549 cells exerted increased expression and activity of CHOP, caspase-4 and JNK, three essential ER-associated apoptotic molecules. In summary, these results demonstrated that asterosaponin 1 inhibits the proliferation of A549 cells through induction of ER stress-associated apoptosis, making asterosaponin 1 a candidate new anticancer drug for lung cancer therapy.

show abstract

Asterosaponins from the starfish Culcita novaeguineae and their bioactivities

Cited by 38 publications

References 15 publications

Synthesis of the Pentasaccharide Moiety of Thornasterside A

Synthesis of the Pentasaccharide Moiety of Thornasterside A

Aphicidal Activity of Starfish (Asterina pectinifera) Extracts against Green Peach Aphid (Myzus Persicae)

Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

Contact Info

Product

Resources

About