Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials

Ma, Baolan; Lu, Jianying; Kang, Tong Ho; Zhu, Ming; Xiong, Ke; Wang, Jinyu

doi:10.1016/j.nutres.2021.09.005

Cited by 14 publications

(9 citation statements)

References 27 publications

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“…Another carotenoid of interest is astaxanthin, which is a xanthophyll with proven antioxidant activity [ 164 ]. A meta-analysis of randomized controlled trials including 380 participants showed that compared with placebo, astaxanthin significantly reduced blood MDA concentration.…”

Section: Natural Antioxidant Bioactive Molecules Against Myocardial I...mentioning

confidence: 99%

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Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Orellana-Urzúa,

Briones-Valdivieso,

Chichiarelli

et al. 2023

Antioxidants

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Stroke and acute myocardial infarction are leading causes of mortality worldwide. The latter accounts for approximately 9 million deaths annually. In turn, ischemic stroke is a significant contributor to adult physical disability globally. While reperfusion is crucial for tissue recovery, it can paradoxically exacerbate damage through oxidative stress (OS), inflammation, and cell death. Therefore, it is imperative to explore diverse approaches aimed at minimizing ischemia/reperfusion injury to enhance clinical outcomes. OS primarily arises from an excessive generation of reactive oxygen species (ROS) and/or decreased endogenous antioxidant potential. Natural antioxidant compounds can counteract the injury mechanisms linked to ROS. While promising preclinical results, based on monotherapies, account for protective effects against tissue injury by ROS, translating these models into human applications has yielded controversial evidence. However, since the wide spectrum of antioxidants having diverse chemical characteristics offers varied biological actions on cell signaling pathways, multitherapy has emerged as a valuable therapeutic resource. Moreover, the combination of antioxidants in multitherapy holds significant potential for synergistic effects. This study was designed with the aim of providing an updated overview of natural antioxidants suitable for preventing myocardial and cerebral ischemia/reperfusion injuries.

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Section: Natural Antioxidant Bioactive Molecules Against Myocardial I...mentioning

confidence: 99%

“…A meta-analysis of randomized controlled trials including 380 participants showed that compared with placebo, astaxanthin significantly reduced blood MDA concentration. This result was particularly significant in patients with type 2 diabetes mellitus [ 164 ].…”

Section: Natural Antioxidant Bioactive Molecules Against Myocardial I...mentioning

confidence: 99%

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Orellana-Urzúa,

Briones-Valdivieso,

Chichiarelli

et al. 2023

Antioxidants

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“…[27][28][29] A recent systematic review and meta-analysis pointed out that astaxanthin supplementation may improve inflammatory and oxidative stress serum markers in humans with type 2 diabetes. 30 Similarly, in animals fed with obesogenic diets and supplemented with low doses of astaxanthin for a long time, it attenuated pro-inflammatory macrophage infiltration (M1 type) in WAT, 31 and also exerted antioxidant effects by reducing the gene expression of heme oxygenase 1 (Hmox-1) and upregulating catalase in WAT, 32 and promoted epigenetic modulation by increasing sirtuin 3 (Sirt3) expression in WATa histone deacetylase that protects against mitochondria damage. 33 These antioxidant activities of astaxanthin may have also contributed to the partial reduction of inflammation.…”

Section: Carotenoids and Their Propertiesmentioning

confidence: 99%

Role of carotenoids in adipose tissue through the AMPK-mediated pathway

et al. 2023

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“…After conducting 12 randomized clinical trials, including 380 participants, Ma and colleagues found that ASX could reduce the levels of biomarkers of oxidative stress and inflammation. Its intake decreased the concentration of blood malondialdehyde, improved the superoxide dismutase activity, and reduced serum isoprostane concentration in overweight patients [ 81 ].…”

Section: The Role Of Astaxanthin In Managing Oxidative Stressmentioning

confidence: 99%

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

et al. 2022

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The current review provides an up-to-date analysis of scientific data on astaxanthin (ASX) sources and experimental studies on its health benefits as a potent antioxidant in the aging process. ASX is a liposoluble carotenoid nutrient and reddish-orange pigment, naturally synthesized by numerous microalgae, yeasts, and bacteria as secondary metabolites. Provides a reddish hue to redfish and shellfish flesh that feed on ASX-producing microorganisms. The microalga Haematococcus pluvialis is the most important source for its industrial bioproduction. Due to its strong antioxidant properties, numerous investigations reported that natural ASX is a more significant antioxidant agent than other antioxidants, such as vitamin C, vitamin E, and β-carotene. Furthermore, several data show that ASX possesses important nutraceutical applications and health benefits, especially in healthy aging processes. However, further studies are needed for a deeper understanding of the potential mechanisms through which ASX could lead to its effective role in the healthy aging process, such as supporting brain health and skin homeostasis. This review highlights the current investigations on the effective role of ASX in oxidative stress, aging mechanisms, skin physiology, and central nervous system functioning, and shows the potential clinical implications related to its consumption.

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Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials

Cited by 14 publications

References 27 publications

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic Stroke

Role of carotenoids in adipose tissue through the AMPK-mediated pathway

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

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