Astaxanthin lowers blood pressure and lessens the activity of the renin-angiotensin system in Zucker Fatty Rats

Preuss, Harry G.; Echard, Bobby; Bagchi, Debasis; Perricone, Nicholas V.; Yamashita, Eiji

doi:10.1016/j.jff.2008.09.001

Cited by 27 publications

(46 citation statements)

References 32 publications

(43 reference statements)

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“…These results indicated that astaxanthin could exert beneficial effects in protection against hypertension and stroke [8,73,74]. In addition, it was shown that astaxanthin lowered blood pressure and lessened the activity of the renin-angiotensin system in Zucker Fatty Rats, indicating that the renin-angiotensin system was involved in the ability of astaxanthin to lower blood pressure [75].…”

Section: Cardiovascular Protective Effectmentioning

confidence: 83%

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

542

309

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The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

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Section: Cardiovascular Protective Effectmentioning

confidence: 83%

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

542

309

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“…We determined that prostate cancer cells could be more sensitive to oxidative stress induced by Cu 2+ . AST is an orange-pinkish carotenoid extensively found in marine organisms, which have various biological activities such as antioxidant, anti-cancer, and anti-inflammatory activities (Preuss et al, 2009;Yang et al, 2013;Kimura et al, 2014). Some results showed that AST protected neuronal cells against oxidative damage, and thus it has been a potent candidate for brain food (Liu and Osawa, 2009), and additionally could protect PC12 cells against glucose toxicity (Zhang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…AST is a type of carotenoid, with antioxidant activity that is 100-1000 times greater than that of vitamin E. AST is commonly found in crustaceans such as shrimp and crab, as well as marine organisms such as salmon, krill, and algae (Barros et al, 2014). As reported, dietary supplementation with AST has beneficial effects in the treatments of inflammation, cardiovascular disease, and oxidative damages, suggesting that AST is a functional food ingredient (Ohgami et al, 2003;Pashkow et al, 2008;Fassett and Coombes, 2009;Preuss et al, 2009). However, there are no reports about the effect of AST on oxidative stress in prostate cell lines, especially in prostate epithelial (RWPE-1) and prostate cancer (PC-3) cell lines treated with Cu 2+ .…”

Section: Introductionmentioning

confidence: 94%

Effects of astaxanthin on oxidative stress induced by Cu2+ in prostate cells

Meng

et al. 2017

J. Zhejiang Univ. Sci. B

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Astaxanthin (AST), a carotenoid molecule extensively found in marine organisms and increasingly used as a dietary supplement, has been reported to have beneficial effects against oxidative stress. In the current paper, the effects of AST on viability of prostate cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay; cell apoptosis and intracellular reactive oxygen species (ROS) levels were determined by flow cytometry; the mitochondrial membrane potential (MMP) was measured by fluorospectrophotometer; and activities of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were evaluated by a detection kit. The results show that copper ion (Cu 2+ ) induced apoptosis, along with the accumulation of intracellular ROS and MDA, in both prostate cell lines (RWPE-1 and PC-3). AST treatments could decrease the MDA levels, increase MMP, and keep ROS stable in RWPE-1 cell line. An addition of AST decreased the SOD, GSH-Px, and CAT activities in PC-3 cell line treated with Cu 2+ , but had a contrary reaction in RWPE-1 cell lines. In conclusion, AST could contribute to protecting RWPE-1 cells against Cu 2+ -induced injuries but could cause damage to the antioxidant enzyme system in PC-3 cells.

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“…These results indicated that astaxanthin could exert beneficial effects in protection against hypertension and stroke 14,79 . In addition, it was shown that astaxanthin lowered blood pressure and lessened the activity of the renin-angiotensin system in Zucker Fatty Rats, indicating that the reninangiotensin system was involved in the ability of astaxanthin to lower blood pressure 80 .…”

Section: Astaxanthin and Inflammationmentioning

confidence: 99%

Untitled

2012

IJPSR

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Astaxanthin, a member of the carotenoid family, is a dark-red pigment which is the main carotenoid found in the marine world of algae and aquatic animals. Astaxanthin, is present in many types of seafood, including salmon, trout, red sea bream, shrimp and lobster, as well as in birds such as flamingo and quail. Synthetic Astaxanthin dominates the world market but recent interest in natural sources of the pigment has increased substantially.

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Astaxanthin lowers blood pressure and lessens the activity of the renin-angiotensin system in Zucker Fatty Rats

Cited by 27 publications

References 32 publications

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Effects of astaxanthin on oxidative stress induced by Cu2+ in prostate cells

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