Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats

Sasaki, Yasuto; Kobara, Nozomi; Higashino, Saori; Giddings, J. C.; Yamamoto, Junichiro

doi:10.1016/j.nutres.2011.09.010

Cited by 42 publications

(28 citation statements)

References 35 publications

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“…The presence of hydroxyl and carbonyl functional groups in ketocarotenoids makes AST excellent antioxidants (Dose et al, 2016;Liu & Osawa, 2007). The high antioxidant power of AST has been shown to have beneficial effects on various diseases related to oxidative damage, such as obesity (Kimura et al, 2014), hypertension (Sasaki, Kobara, Higashino, Giddings, & Yamamoto, 2011), cancer and macular degeneration (Otsuka et al, 2013). Hence, AST has attracted great interest due to its antioxidant capacity and its possible role in reducing the risk of certain diseases.…”

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confidence: 99%

Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Liu

Luo

Rakariyatham

et al. 2016

Journal of Functional Foods

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mentioning

confidence: 99%

Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Liu

Luo

Rakariyatham

et al. 2016

Journal of Functional Foods

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“…Simultaneously, astaxanthin induced vascular relaxation due to an increase in NO level. Another study conducted in the same model has confirmed these analyses highlighting that astaxanthin increases NO bioavailability in brain blood vessels [196]. It can, therefore, be concluded that astaxanthin has antithrombotic effects and can delay the impact of a stroke.…”

Section: Anti-hypertensive Propertiesmentioning

confidence: 53%

Carotenoids of Microalgae Used in Food Industry and Medicine

Gâteau

Solymosi

Marchand

et al. 2017

MRMC

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“…Closed cranial windows were created (Morii et al ., ), and thrombotic tendency was measured as previously described (Sasaki et al ., ; Ikemura et al ., ). In brief, SHRSPs were anesthetized with sodium pentobarbital (60 mg/kg) and artificially ventilated with a mixture of oxygen in air.…”

Section: Methodsmentioning

confidence: 98%

Crocetin, a Carotenoid from Gardenia jasminoides Ellis, Protects against Hypertension and Cerebral Thrombogenesis in Stroke‐prone Spontaneously Hypertensive Rats

Higashino

Sasaki

Giddings

et al. 2014

Phytotherapy Research

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Crocetin is a natural carotenoid dicarboxylic acid that is found in the fruit of Gardenia jasminoides Ellis (Cape Jasmine) and in the stamen and pistil of Crocus sativus L. (saffron). It is used worldwide as an important spice, food colorant, and herbal medicine. In the current investigation, we have examined the cardiovascular effects of crocetin using stroke-prone spontaneously hypertensive rats (SHRSPs). Male SHRSPs (6 weeks old) were classified into three groups: a control group and two crocetin groups (25 and 50 mg/kg/day). The animals were given crocetin for 3 weeks. Body weights in each group were not significantly different during the treatment period, but the increase in systolic blood pressures observed with age was significantly moderated by crocetin. Thrombogenesis, assessed using a He-Ne laser technique in pial vessels, was significantly decreased. Antioxidant activity, assessed by measuring urinary 8-hydroxy-2'-deoxyguanosine levels, together with urinary nitric oxide (NO) metabolite levels, was increased significantly after treatment. Acetylcholine-induced vasodilation was measured using the aorta and indicated that endothelial function was significantly improved by crocetin. These results strongly suggest that the antihypertensive and antithrombotic effects of crocetin were related to an increase in bioavailable NO, possibly mediated by decreased inactivation of NO by reactive oxygen species.

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Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats

Cited by 42 publications

References 35 publications

Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Carotenoids of Microalgae Used in Food Industry and Medicine

Crocetin, a Carotenoid from Gardenia jasminoides Ellis, Protects against Hypertension and Cerebral Thrombogenesis in Stroke‐prone Spontaneously Hypertensive Rats

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