Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Liu, Xiaojuan; Luo, Qingxin; Rakariyatham, Kanyasiri; Cao, Yong; Goulette, Timothy; Xiao, Hang

doi:10.1016/j.jff.2016.05.009

Cited by 67 publications

(36 citation statements)

References 54 publications

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“…In this study we show that the lifespan of C. elegans fed with Astaxanthin increases by about 20%, which is in accordance with previously publish data showing the effects of Astaxanthin on the mean lifespans of the warms (Liu et al . 2016).…”

Section: Introductionsupporting

confidence: 93%

Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III

hoffman

Sultan

Saada

et al. 2019

Preprint

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Astaxanthin is a keto-carotenoid produced in some bacteria and algae, which has very important industrial applications (i.e., in cosmetics, coloring additive in aquaculture and as a dietary supplement for human). Here, we analyzed the molecular basis of Astaxanthin-mediated prolongevity in the model organism, Caenorhabditis elegans. The increased lifespan effects of Astaxanthin are restricted in C. elegans to the adult phase and are uninfluenced by various other carotenoids tested. Genetic analyses indicated that the Astaxanthin-mediated life-extension relies on mitochondria activity, via the Rieske iron-sulfur polypeptide-1 (ISP-1), but is not influenced by the functions of other known longevity-related gene-loci, including CLK-1, DAF-2, DAT-16, EAT-2, GAS-1 GLP-1 or MEV-1. Biochemical analyses of native respiratory complexes showed that Astaxanthin affects the biogenesis of holo-complex III (and likely supercomplex I+III, as well). Effects on holo-CIII assembly and activity were also indicated by in-vitro assays, with mitochondria isolated from worms, rodents, human and plants, which were treated with Astaxanthin. These data indicated a cross-species effect on the oxidative phosphorylation (OXPHOS) machinery by the carotenoid, and provide with further insights into the molecular mechanism of animals longevity extension by Astaxanthin. Significance Statement Astaxanthin is a widely consumed pigment by animals and human. In this study we find that Astaxanthin, but not other tested carotenoids, significantly extends the lifespan of animals by affecting respiratory complex III (CIII) biogenesis of the mitochondria, in plants, C. elegans, rodents and human. We further propose a model to try explaining this effect of astaxanthin on animals’ longevity.

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Section: Introductionsupporting

confidence: 93%

Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III

hoffman

Sultan

Saada

et al. 2019

Preprint

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“…Following the assimilation of CO 2 or carbon substances, these carbon sources are potentially metabolized to biofuels and bioproducts, which are widely used in food, pharmaceutical and feeding industries as well as in energy area. Carotenoids and fatty acids from microalgae have got increasing attention as their potential health benefits are being revealed [ 15 – 17 ]. In addition, microalgae are pointed as the perfect source to produce biodiesel and bioethanol as they convert CO 2 into the biofuels, with higher photosynthetic efficiency and less cultivation space than higher plant [ 18 ].…”

Section: Carbon Metabolism In Microalgaementioning

confidence: 99%

High-value biomass from microalgae production platforms: strategies and progress based on carbon metabolism and energy conversion

Sun

Zhao

Mao

et al. 2018

Biotechnol Biofuels

105

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Microalgae are capable of producing sustainable bioproducts and biofuels by using carbon dioxide or other carbon substances in various cultivation modes. It is of great significance to exploit microalgae for the economical viability of biofuels and the revenues from high-value bioproducts. However, the industrial performance of microalgae is still challenged with potential conflict between cost of microalgae cultivation and revenues from them, which is mainly ascribed to the lack of comprehensive understanding of carbon metabolism and energy conversion. In this review, we provide an overview of the recent advances in carbon and energy fluxes of light-dependent reaction, Calvin–Benson–Bassham cycle, tricarboxylic acid cycle, glycolysis pathway and processes of product biosynthesis in microalgae, with focus on the increased photosynthetic and carbon efficiencies. Recent strategies for the enhanced production of bioproducts and biofuels from microalgae are discussed in detail. Approaches to alter microbial physiology by controlling light, nutrient and other environmental conditions have the advantages of increasing biomass concentration and product yield through the efficient carbon conversion. Engineering strategies by regulating carbon partitioning and energy route are capable of improving the efficiencies of photosynthesis and carbon conversion, which consequently realize high-value biomass. The coordination of carbon and energy fluxes is emerging as the potential strategy to increase efficiency of carbon fixation and product biosynthesis. To achieve more desirable high-value products, coordination of multi-stage cultivation with engineering and stress-based strategies occupies significant positions in a long term.

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“…ABTS radical scavenging activity was measured using the method of [24]. The working solution was prepared by combining 20 mL of 7 mmol/L ABTS•+ with 352 µl of a 140 mmol/L potassium persulphate solution.…”

Section: Abts22'-azino-bis(3 Ethylbenzothiazoline-6-sulphonicacid (Rmentioning

confidence: 99%

Effects of Shrimp Waste Types and Their Cooking on Properties of Extracted Astaxanthin and Its Characteristics in Liposomes

Darachai¹,

Limpawattana²,

Hawangjoo³

et al. 2019

JFNR

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This study was aimed to evaluate the effects of shrimp waste types (fresh head, cooked head, fresh shell and cooked shell) and of cooking these wastes on the properties of astaxanthin. The astaxanthin was subject to liposomal encapsulation and its characteristics were determined. Astaxanthin was extracted from fresh and cooked (90°C for 15 min) materials, and then yield, astaxanthin content, antioxidant activities (DPPH and ABTS scavenging assays) and fatty acid profiles were determined. Phospholipid was used at various concentrations (2, 3 and 4 % w/v) to prepare astaxanthin-loaded liposomes, which were further evaluated for particle size, zeta potential, antioxidant activity (DPPH scavenging assays) and outer structure by confocal laser scanning microscope. The results showed that fresh shrimp heads gave the highest percent yield (30.49 mg extract/g raw material), but the highest astaxanthin content was found in fresh shrimp shells (14.65 mg/g). Shrimp heads and shrimp shells, both fresh and cooked, were significantly different (p<0.05) in terms of their antioxidant activity (based on DPPH and ABTS scavenging assays). Three fatty acids, palmitic acid, oleic acid and linoleic acid were most abundant and found in all samples. However, extract from fresh shrimp shells showed the highest EPA and DHA content of 10.48 % and 11.62 %, respectively. Astaxanthin-loaded liposomes derived were different in size in that the higher concentration, the larger liposomes produced. Liposomes prepared from 4% (w/v) phospholipid at 50 amplitude gave the highest %DPPH scavenging activity of 79.23.

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Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Cited by 67 publications

References 54 publications

Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III

Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III

High-value biomass from microalgae production platforms: strategies and progress based on carbon metabolism and energy conversion

Effects of Shrimp Waste Types and Their Cooking on Properties of Extracted Astaxanthin and Its Characteristics in Liposomes

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