Astaxanthin increase osteocytes, osteoblasts, decrease adipocytes cells, and reduces osteonecrotic events in femoral head of Wistar rats exposed to alcohol.

Wiradiputra, Agus Eka; Suyasa, I Ketut; Astawa, Putu; Kawiyana, Ketut Siki

doi:10.15562/bmj.v7i2.957

Cited by 2 publications

(2 citation statements)

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“…There was only one study reported on the effects of astaxanthin and osteonecrosis (Table 3) (i). In a study by Wiradiputra et al (2018), it was demonstrated that astaxanthin had suppressed bone cell death in alcohol-induced osteonecrosis male rat model [157]. It was well-documented that excessive alcoholism may contribute to a higher risk of femoral head osteonecrosis, where it suppresses bone mesenchymal stem cells (BMSCs) and osteoblast differentiation, leading to altered regeneration of bone [158].…”

Section: Osteonecrosismentioning

confidence: 99%

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Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review

Davan,

Fakurazi,

Alias

et al. 2023

Antioxidants

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In recent years, bone loss and its associated diseases have become a significant public health concern due to increased disability, morbidity, and mortality. Oxidative stress and bone loss are correlated, where oxidative stress suppresses osteoblast activity, resulting in compromised homeostasis between bone formation and resorption. This event causes upregulation of bone remodeling turnover rate with an increased risk of fractures and bone loss. Therefore, supplementation of antioxidants can be proposed to reduce oxidative stress, facilitate the bone remodeling process, suppress the initiation of bone diseases, and improve bone health. Astaxanthin (3,3′-dihydroxy-4-4′-diketo-β-β carotene), a potent antioxidant belonging to the xanthophylls family, is a potential ROS scavenger and could be a promising therapeutic nutraceutical possessing various pharmacological properties. In bone, astaxanthin enhances osteoblast differentiation, osteocytes numbers, and/or differentiation, inhibits osteoclast differentiation, cartilage degradation markers, and increases bone mineral density, expression of osteogenic markers, while reducing bone loss. In this review, we presented the up-to-date findings of the potential anabolic effects of astaxanthin on bone health in vitro, animal, and human studies by providing comprehensive evidence for its future clinical application, especially in treating bone diseases.

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Section: Osteonecrosismentioning

confidence: 99%

“…This finding suggested that using astaxanthin as a potent antioxidant could contribute to osteogenesis and osteoblast formation. However, as only one study has explored the potential use of astaxanthin in alleviating osteonecrosis [157], further investigation is warranted to prove the efficacy of astaxanthin in osteonecrosis treatment.…”

Section: Osteonecrosismentioning

confidence: 99%