2020
DOI: 10.1155/2020/4629189
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Astaxanthin Attenuates Hypertensive Vascular Remodeling by Protecting Vascular Smooth Muscle Cells from Oxidative Stress-Induced Mitochondrial Dysfunction

Abstract: Oxidative stress aggravates mitochondrial injuries and accelerates the proliferation of vascular smooth muscle cells (VSMCs), which are important mechanisms contributing to vascular remodeling in hypertension. We put forward the hypothesis that Astaxanthin (ATX), known to possess strong features of antioxidant, could attenuate vascular remodeling by inhibiting VSMC proliferation and improving mitochondrial function. The potential effects of ATX were tested on spontaneously hypertensive rats (SHRs) and cultured… Show more

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Cited by 61 publications
(60 citation statements)
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References 37 publications
(46 reference statements)
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“…At normal cellular levels, ROS regulate a wide range of cellular responses, including growth, differentiation, ageing, transcription factor activity, and inflammatory reactions 41 - 47 . Nevertheless, abnormal generation of ROS has been discovered to be involved in various diseases, such as cancer, cardiovascular disease, diabetes and skin disorders 45 , 48 - 52 . Deficiency of O 2 in the tumor microenvironment is one of the principal causes of ROS overproduction in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…At normal cellular levels, ROS regulate a wide range of cellular responses, including growth, differentiation, ageing, transcription factor activity, and inflammatory reactions 41 - 47 . Nevertheless, abnormal generation of ROS has been discovered to be involved in various diseases, such as cancer, cardiovascular disease, diabetes and skin disorders 45 , 48 - 52 . Deficiency of O 2 in the tumor microenvironment is one of the principal causes of ROS overproduction in cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…Pigmentos encontrados na maioria das frutas e vegetais, plantas, algas e bactérias resistência a insulina (NI et al, 2015), proteção do músculo liso vascular (CHEN et al, 2020), agente neuroprotetor contra a isquemia do nervo óptico (LIN et al, 2020), homeostase mitocondrial do cálcio (SZTRETYE et al, 2020), prevenção da osteoartrite (SUN et al, 2019), antioxidante e anti-envelhecimento (EREN et al, 2019), proliferação e migração de células cancerosas da mama in vitro (McCall et al, 2018), pigmentação do leite (MEZQUITA et al, 2015), tratamento da dermatite de contato (KIM et al, 2015), supressão de enfisema pulmonar (KUBO et al, 2019), proteção contra danos à retina (OTSUKA et al, 2016), prevenção de lesão pulmonar (CAI et al, 2019), além do uso como aditivos em cosméticos (TOMINAGA et al, 2012).…”
Section: Atividades Biológicas Dos Carotenóidesunclassified
“…Chen et al (2020) reported that this carotenoid also participated in the remodeling of the smooth muscle cells of the vessels, reducing their proliferation and the damage caused by oxidative stress. Astaxanthin lowered RONS levels by increasing the activity of antioxidant enzymes and regulating mitochondrial dynamics, mitophagy and mitochondrial biogenesis, which are important for the maintenance of mitochondrial and cellular metabolism ( 39 ).…”
Section: Mechanisms Of Action Of Astaxanthinmentioning
confidence: 99%