Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet‐induced apoptosis in keratinocytes

Yoshihisa, Yoko; Rehman, Mati Ur; Shimizu, Tadamichi

doi:10.1111/exd.12347

Cited by 83 publications

(72 citation statements)

References 38 publications

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“…The similar result comes from the study was reported by Hassanpour in horses, indicated that between MDA and antioxidant GPx, SOD, CAT, TAC, Vit E, Se, and hemoglobin have strong negative correlation 29 . The study reported by Yoshihisa et al, also showed that UVC irradiation was evidenced to increase the production of ROS such as superoxide (O2), peroxide (H 2 O 2 ), and hydroxyl radical (OH) in the keratinocytes 27 . The study of Fazeli et al, in seminal plasma also indicated that increase in MDA level was invariably followed by a decrease in the level of TAC 30 .…”

Section: Discussionmentioning

confidence: 94%

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Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

Nasihun

Widayati

2016

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Discussionmentioning

confidence: 94%

“…UVC irradiation was carried out using a fluorescent lamp (Philips, UK) that emitted 15 W of UV radiation between 190 and 280 nm (peak 254 nm) 27 . The rats were exposed to UVC irradiation at a distance of 20 cm for 30 minutes daily.…”

Section: Uvc Irradiationmentioning

confidence: 99%

Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

Nasihun

Widayati

2016

JNR

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“…[4][5][6] with functional properties. Their photophysical properties and functionality are influenced by the surrounding environment.…”

Section: 4mentioning

confidence: 99%

Molecular Properties of Astaxanthin in Water/Ethanol Solutions from Computer Simulations

2016

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Astaxanthin (AXT) is a reference model of xanthophyll carotenoids, which is used in medicine and food industry, and has potential applications in nanotechnology. Because of its importance, there is a great interest in understanding its molecular properties and aggregation mechanism in water and mixed solvents. In this paper, we report a novel model of AXT for molecular dynamics simulation. The model is used to estimate different properties of the molecule in pure solutions and in water/ethanol mixtures. 1The calculated diffusion coefficients of AXT in pure water and ethanol are (3.22 ± 0.01) × 10 −6 cm 2 s −1 and (2.7 ± 0.4) × 10 −6 cm 2 s −1 , respectively.Our simulations also show that the content of water plays a clear effect on the morphology of the AXT aggregation in water/ethanol mixture. In up to 75% (v/v) water concentration, loosely connected network of dimers and trimers, and two-dimensional array structures are observed. At higher water concentrations, AXT molecules form more compact three-dimensional structures that are preferentially solvated by the ethanol molecules. The ethanol preferential binding and the formation of a well connected hydrogen bonding network on these AXT clusters, suggest that such preferential solvation can play an important role in controlling the aggregate structure.

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“…Its cell protective effects were demonstrated in the liver and vocal cords as well [10, 11]. AST exhibits reactive oxygen species (ROS) scavenging activity [12] and inhibits UVB-induced apoptosis in keratinocytes [13]. In the eye, AST attenuates retinal damage by reducing apoptosis of retinal ganglion cells in mice through inhibiting oxidative stress [14] and light-induced retinal damage [15].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet‐Induced Photokeratitis in Mice

Harada

Morikawa

Lennikov

et al. 2017

Oxidative Medicine and Cellular Longevity

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Purpose Astaxanthin (AST) has a strong antioxidant cellular membrane chaperone protective effect. Recently, a water-soluble nanosized AST (nano-AST) form was produced, which is expected to improve the efficacy of oral intake effects. The purpose of this study was to examine whether oral nano-AST has therapeutic effects on UV-induced photokeratitis in mice. Methods C57BL/6 mice were administered twice with either nano-AST, AST oil, lutein, or bilberry extracts 3 hours before and shortly before UV irradiation (dose: 400 mJ/cm2). The corneas were collected 24 hours after irradiation and stained with H&E and TUNEL. NF-κB, dihydroethidium (DHE), COX-2, p-IκB-α, TNFα, and CD45 expression were evaluated through immunohistochemistry, Western blot analysis, and qPCR. Results Corneal epithelium was significantly thicker in mice orally administered with nano-AST than in the others (p < 0.01), with significantly less NF-κB nucleus translocation (p < 0.001), and significantly fewer TUNEL cells (p < 0.01). Weaker DHE signals were detected in the nano-AST group (p < 0.05) relative to the others. Furthermore, reduced inflammation and decreased cell death in corneal tissue were observed in the nano-AST group, as indicated by a reduction in the expression of COX-2, p-IκB-α, TNFα, and CD45. Conclusions Oral administration of nano-AST demonstrated a protective effect on UV-induced photokeratitis via antioxidative, anti-inflammatory, and antiapoptotic activity.

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Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet‐induced apoptosis in keratinocytes

Cited by 83 publications

References 38 publications

Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

Molecular Properties of Astaxanthin in Water/Ethanol Solutions from Computer Simulations

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet‐Induced Photokeratitis in Mice

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