Astashine Capsules: A Natural Antioxidant, Anti-inflammatory Helps in Maintaining Lung Health and Minimizing SARS-CoV-2 effects in Covid-19 Infections

Abstract

bioavailable, naturally occurring molecule with strong anti-inflammatory and antioxidant activity, has been shown to (i) significantly attenuate pathological elevation of critical inflammatory cell signaling pathways (NF-kB), (ii) decrease the resulting elevated proinflammatory cytokine levels, (iii) reduce immune cell infiltration of the lung, and (iv) positively influence macrophage polarization in humans and animal models of disease. Corona represents crown-like spikes on the outer surface of the virus thus, it was named as a coronavirus. Coronaviruses are minute in size (65-125 nm in diameter) and contain a single-stranded RNA as a nucleic material, size ranging from 26 to 32kbs in length. The severe acute respiratory syndrome coronavirus (SARS-CoV), H5N1 influenza A, H1N1 2009 and Middle East respiratory syndrome coronavirus (MERS-CoV) cause acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) which leads to pulmonary failure and result in fatality. These viruses were thought to infect only animals until the world witnessed a severe acute respiratory syndrome (SARS) outbreak caused by SARS-CoV, in China. This virus was reported to be a member of the β group of coronaviruses. The novel virus was named as Wuhan coronavirus or 2019 novel coronavirus (2019-nCov) by the Chinese researchers.

Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19

“…Astaxanthin prevents cytokine storms by inhibiting nuclear factor-kB (NF-κB) signaling cascade as well as inflammatory cytokines. It thus has the potential to prevent acute respiratory syndrome due to coronavirus infection ( 11 – 13 ). To reduce and also counteract the severe effects of the virus and the resulting disease, it is necessary to use methods and treatments that reduce anti-inflammatory agents and cytokines.…”