Associative, thermodynamic and thermo-kinetics behavior of di- and triblock copolymers of oxyethylene and oxybutylene in aqueous media

Khan, Abbas; Siddiq, Muhammad

doi:10.1016/j.tca.2014.09.008

Cited by 3 publications

(1 citation statement)

References 47 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chatlier's principle [40] . Furthermore, the mathematical relationship of CMC with temperature derived from closed association model also supports our results Downloaded by [FU Berlin] at 05:19 07 July 2015 [20,21] .…”

Section: Critical Micelle Concentration and Thermodynamic Parameters mentioning

confidence: 99%

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)₆₂-b-(PBO)₃₃Copolymer in Water and its Interaction with Ionic Surfactants

Khan

Siddiq

2015

Journal of Dispersion Science and Technology

Self Cite

View full text Add to dashboard Cite

The physicochemical investigations on the associative, micellar and thermodynamic properties of a diblock (PEO) 62 -b-(PBO) 33 copolymer in aqueous medium and its interaction with ionic surfactants were carried out by using surface tensiometry, laser light scattering and steady-state fluorescence spectroscopy. Surface tension and fluorescence measurements were used to find out the critical micelle concentration (CMC) and related thermodynamic parameters of micellization copolymer at various temperatures. The data from dynamic light scattering (DLS) was helpful to obtain the values of hydrodynamic radii (R h ), volume ( h ) and hydrodynamic expansion parameter ( h ) of the copolymer micelle. Likewise, the measurements from static light scattering (SLS) were employed to determine weight-average molar (M w ), association number (N w ), thermodynamic radius (R t ), thermodynamic volume ( t ), anhydrous volume ( a ) and thermodynamic expansion parameter ( t ) of the copolymer micelles in the temperature range of 20-50 o C. Similarly, the interactions between (PEO) 62 -b-(PBO) 33 and two ionic surfactants, sodium dodecyl sulphate (SDS) and hexadecyltrimethylammonium bromide (CTAB), have also been investigated by fluorescence spectroscopy and DLS at 30 o C. Downloaded by [FU Berlin] at 05:19 07 July 2015 2Similarly, the interactions between (PEO) 62 -b-(PBO) 33 and two ionic surfactants, sodium dodecyl sulfate (SDS) and hexadecyl trimethylammonium bromide (CTAB), have also been investigated by fluorescence spectroscopy and DLS in detail.Graphical Abstract:

show abstract

Section: Critical Micelle Concentration and Thermodynamic Parameters mentioning

confidence: 99%

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)₆₂-b-(PBO)₃₃Copolymer in Water and its Interaction with Ionic Surfactants

Khan

Siddiq

2015

Journal of Dispersion Science and Technology

Self Cite

View full text Add to dashboard Cite

show abstract

Effect of Hydrophilic/Hydrophobic Block Ratio and Temperature on the Surface and Associative Properties of Oxyethylene and Oxybutylene Diblock Copolymers in Aqueous Media

Khan

Akil

Siddiq

2015

Journal of Dispersion Science and Technology

View full text Add to dashboard Cite

Effect of ethanol and sodium chloride on the physio-chemical properties of Montelukast sodium and its interaction with DNA

Khan

Shahid

Khan

et al. 2023

Zeitschrift Für Physikalische Chemie

View full text Add to dashboard Cite

In drug development, it is very important to study the physicochemical properties of drugs under various solution conditions in order to understand their mechanism of action and their interactions with bioactive compounds. In this regard, this study attempts to elucidate the effects of co-solvent and co-solute on the physicochemical properties of Montelukast sodium and its possible interactions with deoxyribonucleic acid (DNA). The physicochemical, volumetric and thermodynamic properties of Montelukast sodium were determined by various measurements such as density, viscosity and surface tension. Most of these measured parameters responded differently when ethanol (co-solvent) and sodium chloride (co-solvent) were added to the drug solution, and/or when the concentration and temperature of the drug solution were changed. Various solution properties such as flow behavior, surface activity and association behavior of Montelukast sodium were also affected by the addition of DNA. UV–Vis spectroscopy was also used to better understand the qualitative and quantitative strength of DNA-drug interactions in water. Using UV–Visible analysis, the Montelukast DNA binding constant (Kb) was determined to be 6.861 × 103 (L Mol−1). Physicochemical and spectroscopic results confirmed that there may be physicochemical type interactions between the drug and DNA. It is also proposed that hydrogen bonding can occur between the oxygen and hydrogen atoms of the Montelukast sodium and the hydrogen, oxygen and nitrogen atoms of the DNA molecule.

show abstract

Associative, thermodynamic and thermo-kinetics behavior of di- and triblock copolymers of oxyethylene and oxybutylene in aqueous media

Cited by 3 publications

References 47 publications

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)₆₂-b-(PBO)₃₃Copolymer in Water and its Interaction with Ionic Surfactants

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)₆₂-b-(PBO)₃₃Copolymer in Water and its Interaction with Ionic Surfactants

Effect of Hydrophilic/Hydrophobic Block Ratio and Temperature on the Surface and Associative Properties of Oxyethylene and Oxybutylene Diblock Copolymers in Aqueous Media

Effect of ethanol and sodium chloride on the physio-chemical properties of Montelukast sodium and its interaction with DNA

Contact Info

Product

Resources

About

Associative, thermodynamic and thermo-kinetics behavior of di- and triblock copolymers of oxyethylene and oxybutylene in aqueous media

Cited by 3 publications

References 47 publications

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)62-b-(PBO)33Copolymer in Water and its Interaction with Ionic Surfactants

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)62-b-(PBO)33Copolymer in Water and its Interaction with Ionic Surfactants

Effect of Hydrophilic/Hydrophobic Block Ratio and Temperature on the Surface and Associative Properties of Oxyethylene and Oxybutylene Diblock Copolymers in Aqueous Media

Effect of ethanol and sodium chloride on the physio-chemical properties of Montelukast sodium and its interaction with DNA

Contact Info

Product

Resources

About

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)₆₂-b-(PBO)₃₃Copolymer in Water and its Interaction with Ionic Surfactants

Physicochemical Investigation of the Micellar Behavior of a Diblock (PEO)₆₂-b-(PBO)₃₃Copolymer in Water and its Interaction with Ionic Surfactants