Associative recognition in mild cognitive impairment: Relationship to hippocampal volume and apolipoprotein E

Troyer, Angela K.; Murphy, Kelly J.; Anderson, Nicole; Craik, Fergus I. M.; Moscovitch, Morris; Maione, Andrea; Gao, Fuqiang

doi:10.1016/j.neuropsychologia.2012.10.018

Cited by 61 publications

(59 citation statements)

References 65 publications

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“…These findings are in accordance with the previous studies that highlighted poorer associative memory performance in prAD patients than in older controls (Atienza et al, 2011;Hampstead et al, 2011;Hanseeuw et al, 2011;Sperling, 2007;Troyer et al, 2012;Troyer et al, 2008).…”

Section: Ffr Performance and Recall Transition Analysissupporting

confidence: 93%

Investigating Associative Learning Effects in Patients with Prodromal Alzheimer’s Disease Using the Temporal Context Model

Quenon

Xivry

Hanseeuw

et al. 2015

J Int Neuropsychol Soc

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Objective: The purpose of this study was to investigate associative learning effects in patients with prodromal Alzheimer's disease (prAD) by referring to the Temporal Context Model (TCM; Howard, Jing, Rao, Provyn, & Datey, 2009), in an attempt to enhance the understanding of their associative memory impairment. TCM explains fundamental effects described in classical free-recall tasks and cued-recall tasks involving overlapping word pairs (e.g., A-B, B-C), namely (1) the contiguity effect, which is the tendency to successively recall nearby items in a list, and (2) the observation of backward (i.e., B-A) and transitive associations (i.e., A-C) between items. In TCM, these effects are hypothesized to rely on contextual representation, binding and retrieval processes, which supposedly depend on hippocampal and parahippocampal regions. As these regions are affected in prAD, the current study investigated whether prAD patients would show reduced proportions of backward and transitive associations in free and cued-recall, coupled to a reduced contiguity effect in freerecall.Method: Seventeen older controls and 17 prAD patients performed a cued-recall task implying overlapping word pairs and a final free-recall task.Results: Proportions of backward and transitive intrusions in cued-recall did not significantly differ between groups. However, in free-recall, prAD patients demonstrated a reduced contiguity effect as well as reduced proportions of backward and transitive associations compared to older controls.Conclusions: These findings are discussed within the hypothesis that the contextual representation, binding and/or retrieval processes are affected in prAD patients compared to healthy older individiuals.

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Section: Ffr Performance and Recall Transition Analysissupporting

confidence: 93%

Investigating Associative Learning Effects in Patients with Prodromal Alzheimer’s Disease Using the Temporal Context Model

Quenon

Xivry

Hanseeuw

et al. 2015

J Int Neuropsychol Soc

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“…The present findings may also have clinical relevance because declining face-name memory is not only a hallmark of aging (e.g., Crook & West, 1990) but can also be a symptom of mild cognitive impairment (Hampstead, Sathian, Moore, Nalisnick, & Stringer, 2008;Troyer et al, 2012) and progression to Alzheimer's disease (Werheid & Clare, 2007). To date, most interventions aimed at improving face-name memory in older adults have focused on training explicit memory strategies (Hampstead et al, 2008) and imagery (Belleville et al, 2006).…”

Section: Discussionmentioning

confidence: 66%

Face–name learning in older adults: a benefit of hyper-binding

et al. 2016

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Difficulty remembering faces and corresponding names is a hallmark of cognitive aging, as is increased susceptibility to distraction. Given evidence that older adults spontaneously encode relationships between target pictures and simultaneously occurring distractors (a hyper-binding phenomenon), we asked whether memory for face-name pairs could be improved through prior exposure to faces presented with distractor names. In three experiments, young and older adults performed a selective attention task on faces while ignoring superimposed names. After a delay, they learned and were tested on face-name pairs that were either maintained or rearranged from the initial task but were not told of the connection between tasks. In each experiment, older but not younger participants showed better memory for maintained than for rearranged pairs, indicating that older adults' natural propensity to tacitly encode and bind relevant and irrelevant information can be employed to aid face-name memory performance.

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“…Step 2 Step 3 why effects on global hippocampal volume are subtler, observed in some studies [4][5][6][7][8][9] but not others. [10][11][12] A particular strength of our study is the finding of a possible symptomatic consequence of APOE e4-associated CA1-SRLM thinning, which appeared to mediate the relationship between carrier status and the integrity of episodic memory.…”

Section: Resultsmentioning

confidence: 99%

APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory

et al. 2014

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Objectives: Using high-resolution structural MRI, we endeavored to study the relationships among APOE e4, hippocampal subfield and stratal anatomy, and episodic memory.Methods: Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, and 14 age-matched healthy controls with no group differences in APOE e4 carrier status. Each subject underwent ultra-high-field 7.0-tesla MRI targeted to the hippocampus and neuropsychological assessment.Results: We found a selective, dose-dependent association of APOE e4 with greater thinning of the CA1 apical neuropil, or stratum radiatum/stratum lacunosum-moleculare (CA1-SRLM), a hippocampal subregion known to exhibit early vulnerability to neurofibrillary pathology in Alzheimer disease. The relationship between the e4 allele and CA1-SRLM thinning persisted after controlling for dementia severity, and the size of other hippocampal subfields and the entorhinal cortex did not differ by APOE e4 carrier status. Carriers also exhibited worse episodic memory function but similar performance in other cognitive domains compared with noncarriers. In a statistical mediation analysis, we found support for the hypothesis that CA1-SRLM thinning may link the APOE e4 allele to its phenotypic effects on memory. Conclusions:The APOE e4 allele segregated dose-dependently and selectively with CA1-SRLM thinning and worse episodic memory performance in a pool of older subjects across a cognitive spectrum. These findings highlight a possible role for this gene in influencing a critical hippocampal subregion and an associated symptomatic manifestation. Neurology ® 2014;82:691-697 GLOSSARY AD 5 Alzheimer disease; aMCI 5 amnestic mild cognitive impairment; ANOVA 5 analysis of variance; CA1-SP 5 CA1 stratum pyramidale; CA1-SRLM 5 CA1 stratum radiatum/lacunosum-moleculare; CDR 5 Clinical Dementia Rating; DG/CA3 5 dentate gyrus and CA3; ERC 5 entorhinal cortex; MTL 5 medial temporal lobe; NIA-AA 5 National Institute on Aging-Alzheimer's Association; OC 5 older control.ApoE influences the metabolism of b-amyloid, the major peptide constituent of amyloid plaques in Alzheimer disease (AD).1 The ApoE4 isoform confers an increased risk of sporadic late-onset AD dementia. 2,3Carriers of the APOE e4 allele who have AD dementia or its clinical precursor, amnestic mild cognitive impairment (aMCI), exhibit greater hippocampal volume loss than noncarriers in some studies, 4-9 although this finding is controversial. [10][11][12] Perhaps these divergent findings arise from disproportionate effects of the e4 allele on individual hippocampal subfields that are not always evident in global volumetric analyses.Specific effects of the APOE e4 allele on hippocampal subfields are of interest. AD-related neuropathology itself is subfield-and even strata-selective, affecting the CA1 subfield, including specifically the stratum radiatum/stratum lacunosum-moleculare (CA1-SRLM), before affecting the remainder of the hippocampus. [13][14][15...

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Associative recognition in mild cognitive impairment: Relationship to hippocampal volume and apolipoprotein E

Cited by 61 publications

References 65 publications

Investigating Associative Learning Effects in Patients with Prodromal Alzheimer’s Disease Using the Temporal Context Model

Investigating Associative Learning Effects in Patients with Prodromal Alzheimer’s Disease Using the Temporal Context Model

Face–name learning in older adults: a benefit of hyper-binding

APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory

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