Associations SELE Gene Haplotype Variant and Hypertension in Mongolian and Han Populations

Abstract

Genetic variation is thought to contribute to the etiology of hypertension, and E-selectin is a candidate essential hypertension-associated gene. Objective In this study, we attempted to test the hypothesis that subtle haplotype variants of SELE genes may be sources of essential hypertension in Mongolian and Han populations. Materials A total of 429 unrelated Mongolian herdsmen and 416 Han farmers were enrolled, including 212 Mongolian essential hypertension (EH) patients, 217 Mongolian normotensives (controls), 200 Han EH patients and 216 Han normotensives (controls). Methods All nine tag single-nucleotide polymorphisms (SNPs) within the SELE gene were retrieved from HapMap and the genotyping was performed using a polymerase chain reaction (PCR)/ligase detection reaction assay. Results The distributions of the A-allele frequency of rs3917458 and the C-allele frequency of rs2179172 differed significantly between the hypertensive subjects and controls in the Han population. The frequency of haplotype GGC was significantly higher in the EH group than in the controls in the Mongolian population. In the Han population, a significant difference was observed in the haplotype frequency of TCC between the patients and controls, whereas haplotype ACA was detected significantly less often in the EH subjects than in the controls. Conclusion Meanwhile, the haplotype TCC in the Han hypertensive patients and the haplotype GGC in the Mongolian patients had independent effects in increasing the risk for EH and maybe used as risk factors for predicting high blood pressure. However, the haplotype ACA had an independent effect in decreasing the risk of hypertension and may be protective in normotensive subjects in the Han population. Therefore, multiple SNPs in combination in SELE may confer a risk of hypertension.

Prevalence of and risk factors for refractive error: a cross-sectional study in Han and Mongolian adults aged 40–80 years in Inner Mongolia, China

“…The results for myopia and hyperopia were compared with those of emmetropic individuals myopia, whereas Mongolian ethnicity was a risk factor for hyperopia. Apart from indicators included in our study, differences between Han and Mongolian populations have also been found in their genetic background [10,[15][16][17]31], diet [18], alcohol consumption [32], sleeping habits [33,34], body structure [35,36] and morphological traits [37]. The differences in the prevalence of and risk factors for RE in the Han and Mongolian populations could not be explained by the differences in the risk factors investigated in this study.…”

“…Other studies have suggested that in the Mongolian population, the risk of cardiovascular diseases is higher than in the Han population [12,13], but the risk of stroke is lower [14]. Moreover, there is some evidence suggesting that the difference in the risk of diseases might be based on the genetic heterogeneity [15][16][17] and different lifestyles such as dietary habits [18] between the Han and Mongolian populations.…”

Hypertension and physical activity in middle-aged and older adults in China

“…Third, genetic factors are another important factor associated with hypertension in China. Many related studies had been performed in China and the results showed that human cytochrome P450 had the most important influence on the development of essential hypertension in China 17 – 19 . However, no consideration was given to this factor in this study because of the lack of genetic information.…”

MACROD2 Polymorphisms Are Associated with Hypertension in Korean Population

“…으로 알려져 있는데 [7][8][9], 그 중에서 MACROD2 (MACRO domain containing 2) 유전자가 심혈관 질환 및 고혈압과 상관 관계가 있는 것으로 발표되었다 [10][11][12][13]. MACROD2는 mono-ADP-ribosylated 된 단백질로부터 ADP-ribose를 제거하는 데 관여하는 탈아세틸화효소의 기능을 가지고 있는데, DNA 손 상 시 핵에서 세포질로 전위하는 것으로 나타났으며, 이는 태아 와 성인의 뇌, 흉선, 골격근, 간, 췌장, 전립선, 신장, 폐에서 발현 하며 쥐 배아와 성체의 in situ hybridization과 RT-PCR분석에 서 배아일 12.5일에서 성년기까지 두뇌, 특히 심실영역에서의 발현을 나타냈다 [14].…”