Associations of Walking Speed, Grip Strength, and Standing Balance With Total and Cause-Specific Mortality in a General Population of Japanese Elders

Nofuji, Yu; Shinkai, Shoji; Taniguchi, Yu; Amano, Hidenori; Nishi, Mariko; Murayama, Hiroshi; Fujiwara, Yoshinori; Suzuki, Takao

doi:10.1016/j.jamda.2015.11.003

Cited by 100 publications

(110 citation statements)

References 28 publications

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“…Walking speed, an indicator of biological aging, was associated with increased cardiovascular mortality, but no association was found with cancer mortality . Similar observations have been reported for grip strength and standing balance . Consistent with these findings, telomere length, although strongly associated with longevity, has shown associations with cancer risk that were less clear and probably type‐specific …”

supporting

confidence: 79%

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Dugué

Bassett

Joo

et al. 2017

Intl Journal of Cancer

159

156

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The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methylation and called them "age acceleration." We aimed to assess the associations of age acceleration with risk of and survival from seven common cancers. Seven case-control studies of DNA methylation and colorectal, gastric, kidney, lung, prostate and urothelial cancer and B-cell lymphoma nested in the Melbourne Collaborative Cohort Study were conducted. Cancer cases, vital status and cause of death were ascertained through linkage with cancer and death registries. Conditional logistic regression and Cox models were used to estimate odds ratios (OR) and hazard ratios (HR) and 95% confidence intervals (CI) for associations of five age acceleration measures derived from the Human Methylation 450 K Beadchip assay with cancer risk (N = 3,216 cases) and survival (N = 1,726 deaths), respectively. Epigenetic aging was associated with increased cancer risk, ranging from 4% to 9% per five-year age acceleration for the 5 measures considered. Heterogeneity by study was observed, with stronger associations for risk of kidney cancer and B-cell lymphoma. An associated increased risk of death following cancer diagnosis ranged from 2% to 6% per five-year age acceleration, with no evidence of heterogeneity by cancer site. Cancer risk and mortality were increased by 15-30% for the fourth versus first quartile of age acceleration. DNA methylation-based measures of biological aging are associated with increased cancer risk and shorter cancer survival, independently of major health risk factors.

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supporting

confidence: 79%

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Dugué

Bassett

Joo

et al. 2017

Intl Journal of Cancer

159

156

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“…The criteria for the assessment of physical frailty specified by Fried et al, which include weight loss, exhaustion, physical activity, walking speed (WS) and grip strength (GS), have been widely used . There is considerable research concerning the interrelationships among these five criteria, as well as the effects of each criterion on fatality risk and rate of nursing care service utilisation …”

Section: Introductionmentioning

confidence: 99%

Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross‐sectional study

Hihara

Goto

Ichikawa

2019

J of Oral Rehabilitation

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No report has yet examined the impact of oral hypofunction on physical frailty in relation to intra‐relationships of physical frailty assessment items. The purpose of this study was to verify the potential of a clinical cascade between oral hypofunction and physical frailty, and especially to support the hypothesis that the influence of oral hypofunction on physical frailty is greater than the intra‐relationships among elements of physical frailty and that sex differences significantly affect these relationships. The participants were 272 older adults (101 men and 171 women; mean age 75.1 ± 7.5 years). Maximum occlusal force (MOF) and oral dryness (OD), as indicators of oral hypofunction, and grip strength (GS) and walking speed (WS), as indicators of physical frailty, were measured. Mutual relationship of four variables was verified using covariance structure analysis. In men, three paths from MOF to WS and GS and from WS to GS were confirmed, and those from MOF to WS and from WS to GS were found to be significant (P < .01). In women, three paths from MOF to WS and GS and from WS to GS were also confirmed, as with the men, and those from MOF to WS and from MOF to GS were found to be significant (P < .01). Model adaptability was shown to be good for both men and women. The results suggest our hypothesis was verified, and it is expected that the early detection of oral hypofunction, that is MOF, may be important for assessing physical frailty, especially in women.

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“…Second, we collected data for a large number of sociomedical variables, which were included in the statistical models as confounders. The results showed that baPWV trajectory pattern was significantly associated with all‐cause mortality, even after controlling for sociodemographic factors, physical performance, chronic diseases and blood pressure, all of which were previously identified as risk factors for death.…”

Section: Discussionmentioning

confidence: 99%

Trajectories of arterial stiffness and all‐cause mortality among community‐dwelling older Japanese

Taniguchi

Kitamura

Shinozaki

et al. 2018

Geriatrics Gerontology Int

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Associations of Walking Speed, Grip Strength, and Standing Balance With Total and Cause-Specific Mortality in a General Population of Japanese Elders

Cited by 100 publications

References 28 publications

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross‐sectional study

Trajectories of arterial stiffness and all‐cause mortality among community‐dwelling older Japanese

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