Associations of Tobacco Smoking with Impaired Endothelial Function: The Circulatory Risk in Communities Study (CIRCS)

Cui, Meishan; Cui, Renzhe; Liu, Keyang; Dong, Jia-Yi; Imano, Hironori; Hayama‐Terada, Mina; Muraki, Isao; Kiyama, Masahiko; Okada, Takeo; Kitamura, Akihiko; Umesawa, Mitsumasa; Yamagishi, Kazumasa; Ohira, Tetsuya; Iso, Hiroyasu

doi:10.5551/jat.42150

Cited by 22 publications

(20 citation statements)

References 29 publications

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“…In the present study, we corroborated the previously reported, strong relationship between NAFLD and sE‐selectin . In addition, using large cohorts we are able to adjust for potential confounding factors, such as smoking, low‐grade inflammation, plasma lipids, type 2 diabetes and cardiovascular disease, which have all been associated with systemic endothelial dysfunction . We observed that plasma ALT levels were associated with sE‐selectin, independent of these potential confounders.…”

Section: Discussionsupporting

confidence: 90%

The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease

Simons

Bijnen

Wouters

et al. 2020

Liver International

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Abbreviations: AFLD, alcoholic fatty liver disease; CODAM, Cohort on Diabetes and Atherosclerosis Maastricht; CVD, cardiovascular disease; GCKR, glucokinase regulatory protein; IGM, impaired glucose metabolism; NAFLD, nonalcoholic fatty liver disease; NAS, NAFLD activity score; NASH, nonalcoholic steatohepatitis; NGM, normal glucose metabolism; PNPLA3, patatin-like phospholipase domain-containing protein 3; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhesion molecule-1; T2DM, type 2 diabetes; VAT, visceral adipose tissue. AbstractBackground & Aims: Plasma soluble E-selectin (sE-selectin) is a frequently used biomarker of systemic endothelial dysfunction. The present study explored the relationship between nonalcoholic fatty liver disease (NAFLD) and plasma sE-selectin levels. Methods:Expression of E-selectin in liver, visceral adipose tissue (VAT) and muscle was studied in relation to plasma sE-selectin in severely obese individuals (n = 74).The course of hepatic E-selectin expression in relation to hepatic steatosis and inflammation was examined in C57BL/6J LDLR −/− mice on a Western-type diet. The relationship between biomarkers of NAFLD, that is, plasma aminotransferase (ALT) and

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Section: Discussionsupporting

confidence: 90%

The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease

Simons

Bijnen

Wouters

et al. 2020

Liver International

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“…Even though these hemodynamic adaptations may reflect sympathetic activation, the evidence regarding endothelial function depression points clearly to other causes rather than a mere autonomic modulation. Endothelial dysfunction is a pathophysiological state in which normal homeostatic properties of the vessels wall are damaged or lost [20] , and consistently with other studies involving either short-term [20][21][22][23][24][25] or long-term smokers [29,30] , our results clearly demonstrated changes in endothelial function as evaluated with the FMD method. It is noteworthy that baseline FMD was significantly lower in AG compared to both the CG and the PG, hence some degree of depression of endothelial function was already present in the smokers, as in Yufu et al [31] , in which 26 young active smokers were compared with 31 young non-smokers, and FMD was shown to be significantly lower in the smoking group, even though no significant difference was found regarding brachialankle PWV.…”

Section: Discussionsupporting

confidence: 90%

Acute Effects of Smoking on the Arterial Function of Young Healthy Smokers

Pereira

Costa

2019

Journal of Cardiology and Therapy

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BACKGROUND: Several studies have supported the idea that smoking induces changes with direct impact on endothelial function and arterial stiffness. The main purpose of this study was to assess the acute effects of smoking on vascular function in healthy young adults. METHODS: We designed a quasi-experimental study, including ninety participants aged between 18 and 25 years. Participants were divided into three groups: Active exposure group (AG)-30 usual smokers; passive exposure group (PG) and non-exposure control group (CG), each including 30 non-smokers matched for age, gender and overall lifestyle. Heart rate (HR), brachial blood pressure (bBP), flow-mediated dilation (FMD), aortic pulse wave velocity (PWV) and carotid pulse wave analysis (PWA) were evaluated in two moments: baseline and 30 minutes after smoking exposition (AG and PG) or 30 minutes after the first evaluation (CG). RESULTS: Significant changes from baseline were observed only in the AG, with an increase in PWV, from 5.6 ± 0.7 m/s to 6.1 ± 0.2 m/ s post-smoking (p = 0.040), and a decrease in FMD of about-5.7 ± 2.3% after smoking one cigarette (p < 0.001). A significant increase in brachial and central BP was also observed in the AG. A trend for increase in brachial and central BP, and decrease in the FMD was observed in the PG and no significant changes were depicted in the CG. CONCLUSION: Just one cigarette produces significant detrimental acute effects on the vascular endothelium and hemodynamic profile of healthy young short-term smokers. Changes are also observed, although to a lesser extent, in passive smokers.

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“…Promoting aging and damaging organ systems, cigarette smoke contains various chemical substances, provoking deleterious effects on the human body 1 – 6 ) . In the cardiovascular system, smoking induces vascular endothelial damage and accelerates the progression of atherosclerosis 7 – 12 ) . With its incidence increasing even in individuals with low levels of smoking or smoking with low-tar tobacco, cardiovascular disease is the leading cause of death in many parts of the world 8 – 11 ) .…”

Section: Introductionmentioning

confidence: 99%

Close Association between Subclinical Atherosclerosis and Pulmonary Function in Middle-Aged Male Smokers

Sugiura

Dohi

Takagi

et al. 2020

JAT

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Aims: Cigarette smoking provokes deleterious influences on cardiovascular and pulmonary systems, although the underlying relationship has not been sufficiently investigated especially in early-stage disease. The present study investigated possible associations between subclinical atherosclerosis and pulmonary function in middle-aged male smokers. Methods: Male smokers undergoing their periodic health check-up were enrolled in this study ( n = 3,775, 45 ± 8 years). Pulmonary function was evaluated using spirometry by calculating forced vital capacity (FVC) as a percentage of predicted value (FVC%-predicted), forced expiratory volume in one second (FEV1) as a percentage of predicted value (FEV1%-predicted), and the ratio of FEV1 to FVC (FEV1/FVC). Subclinical atherosclerosis was assessed based on ankle-brachial pressure index (ABI), cardio-ankle vascular index (CAVI), ultrasound examination of the carotid intima-media thickness (IMT), and presence of plaque. Results: Multivariate regression analysis showed that ABI was positively associated with FVC%-predicted and FEV1%-predicted after adjustment for confounders including smoking intensity, while CAVI or carotid IMT was inversely associated with both. Participants with chronic obstructive pulmonary disease (COPD, n = 256) showed reduced ABI and increased CAVI or carotid IMT compared with those without COPD, and participants with carotid plaque had lower pulmonary function than those without plaque. Reduced FEV1/FVC was an independent determinant of carotid plaque and decreased ABI was an independent determinant of COPD, as revealed by logistic regression analysis with the endpoint of carotid plaque presence or a diagnosis of COPD revealed. Conclusions: Middle-aged male smokers showed a close association between subclinical atherosclerosis and pulmonary function, implying that smoking induced-vascular and pulmonary damage are interacting in early-stage disease.

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Associations of Tobacco Smoking with Impaired Endothelial Function: The Circulatory Risk in Communities Study (CIRCS)

Cited by 22 publications

References 29 publications

The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease

The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease

Acute Effects of Smoking on the Arterial Function of Young Healthy Smokers

Close Association between Subclinical Atherosclerosis and Pulmonary Function in Middle-Aged Male Smokers

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