Close Association between Subclinical Atherosclerosis and Pulmonary Function in Middle-Aged Male Smokers

Sugiura, Tomonori; Dohi, Yasuaki; Takagi, Yasuyuki; Yokochi, Takashi; Yoshikane, Naofumi; Suzuki, Kenji; Tomiishi, Takamasa; Nagami, Takashi; Iwase, Mitsunori; Takase, Hiroyuki; Seo, Yoshihiro; Ohte, Nobuyuki

doi:10.5551/jat.55996

Cited by 8 publications

(15 citation statements)

References 55 publications

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“…Although, in the present study, we examined neither vascular endothelial function nor parameters regarding oxidative stress or inflammation, we previously reported that oxidative stress and inflammation are significantly associated with vascular endothelial dysfunction and increased arterial stiffness 10,11,35,42) . Decreased elasticity in the arterial walls has been reported as a mechanism underlying increased arterial stiffness, and physiological alterations with aging and inflammatory modifications being possible factors leading to decreased elasticity in the presence of increased arterial stiffness 19,20) . Thus, vascular impairment in the small and large arteries may simultaneously initiate and progress through increasing oxidative stress and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Arterial stiffness was assessed by CAVI using a Vasera VS-1000 automatic system (Fukuda Denshi, Tokyo, Japan), as described previously [17][18][19][20] , after resting in the supine position. Electrocardiogram electrodes and a microphone were placed on both wrists and the sternum to detect heart sounds.…”

Section: Assessment Of Arterial Stiffness In a Muscular Arterymentioning

confidence: 99%

“…However, the model in which CAVI and carotid IMT were simultaneously atherosclerotic examination in large arteries and small artery retinopathy based on Scheie classification was confirmed in untreated middle-aged individuals, supporting the finding that vascular damage progresses in association with small and large arteries from an early stage. Atherosclerosis examinations are widely performed, and CAVI and carotid IMT are representatives of functional and morphological assessments in large muscular and elastic arteries [17][18][19][20][21][22][23] . The usefulness of atherosclerotic examinations has been established not only in individuals with progressive atherosclerosis in clinical settings, but also in the asymptomatic general population at health check-ups 19,20,23,[32][33][34][35] .…”

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

“…Atherosclerosis examinations are widely performed, and CAVI and carotid IMT are representatives of functional and morphological assessments in large muscular and elastic arteries [17][18][19][20][21][22][23] . The usefulness of atherosclerotic examinations has been established not only in individuals with progressive atherosclerosis in clinical settings, but also in the asymptomatic general population at health check-ups 19,20,23,[32][33][34][35] . The ability to detect subclinical atherosclerosis in asymptomatic individuals is not so great with a single examination, though it could be improved by combining the examinations.…”

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

“…In the clinical setting, the extent of subclinical atherosclerosis is mainly evaluated in large arteries by non-invasive examinations, including the cardio-ankle vascular index (CAVI) and carotid intima-media thickness (IMT) 17) . CAVI is a functional index that indicates arterial stiffness, which is pathologically characterized by decreased arterial elasticity [17][18][19][20] , whereas carotid IMT is a morphological index of atherosclerotic vascular damage that reflects pathological thickening in the vascular wall [19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

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Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals

Sugiura

Dohi

Takagi

et al. 2022

JAT

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Small arteries can be visualized in the ocular fundus, and findings of retinopathy based on Scheie classification are often applied to evaluate the impact of hypertension and atherosclerosis. However, the relationship between damage in the large and small arteries has not been investigated sufficiently, especially in the early stages. The present study investigated possible associations between large artery atherosclerosis and small artery retinopathy in untreated middle-aged individuals. Methods: Untreated middle-aged workers undergoing periodic health checkups (n 7,730, 45 8 years) were enrolled in this study. The absence or presence and extent of retinopathy were characterized by ophthalmologists as hypertensive (H0-4) and atherosclerotic grades (S0-4) based on Scheie classification. Large artery atherosclerosis was examined based on functional assessment of the cardio-ankle vascular index (CAVI) and morphological assessment of the carotid intima-media thickness (IMT) by ultrasound. Results: We found significant differences in CAVI and carotid IMT between individuals with and without hypertensive or atherosclerotic retinopathy. Multivariable regression analysis showed that the presence of hypertensive and atherosclerotic retinopathy was significantly associated with CAVI and carotid IMT. Logistic regression analysis with the endpoint of a hypertensive or atherosclerotic lesion revealed that CAVI and carotid IMT are independent determinants of retinopathy. Conclusions: CAVI and carotid IMT were significantly associated with the presence of retinopathy based on Scheie classification in untreated middle-aged subjects, implying that atherosclerotic examination in large arteries could reveal early-stage small artery retinopathy. changes that lead to primary organ damage 1-5). Hence, preventing the progressive processes of atherosclerosis is one of the most critical strategies in public health. Hypertension, dyslipidemia, diabetes mellitus, and smoking promoted atherosclerosis are established cardiovascular risk factors related to unhealthy Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Arterial Stiffness In a Muscular Arterymentioning

confidence: 99%

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals

Sugiura

Dohi

Takagi

et al. 2022

JAT

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Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study

Maitusong

Laguzzi

Strawbridge

et al. 2023

Circ: Genomic and Precision Medicine

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Background: Smoking is associated with carotid intima-media thickness (C-IMT). However, knowledge about how genetics may influence this association is limited. We aimed to perform nonhypothesis driven gene-smoking interaction analyses to identify potential genetic variants, among those included in immune and metabolic platforms, that may modify the effect of smoking on carotid intima-media thickness. Materials: We used baseline data from 1551 men and 1700 women, aged 55 to 79, included in a European multi-center study. Carotid intima-media thickness maximum, the maximum of values measured at different locations of the carotid tree, was dichotomized with cut point values ≥75, respectively. Genetic data were retrieved through use of the Illumina Cardio-Metabo- and Immuno- Chips. Gene-smoking interactions were evaluated through calculations of Synergy index (S). After adjustments for multiple testing, P values of <2.4×10 −7 for S were considered significant. The models were adjusted for age, sex, education, physical activity, type of diet, and population stratification. Results: Our screening of 207 586 SNPs available for analysis, resulted in the identification of 47 significant gene-smoking synergistic interactions in relation to carotid intima-media thickness maximum. Among the significant SNPs, 28 were in protein coding genes, 2 in noncoding RNA and the remaining 17 in intergenic regions. Conclusions: Through nonhypothesis-driven analyses of gene-smoking interactions, several significant results were observed. These may stimulate further research on the role of specific genes in the process that determines the effect of smoking habits on the development of carotid atherosclerosis.

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Association Between Airflow Limitation and Carotid Intima-Media Thickness in the Japanese Population

Watanabe¹,

Onoue²,

Omori³

et al. 2021

COPD

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Purpose This study aimed to reveal the association between airflow limitation (AL) and carotid intima-media thickness (IMT) according to smoking status in Japan. Subjects and Methods This cross-sectional study was performed in 2809 subjects, who underwent a comprehensive health examination with pulmonary function tests and carotid ultrasonographic measurement. AL was defined as forced expiratory volume in 1 s/forced vital capacity of <0.7. The subjects were divided into the following four groups: never smokers without AL, never smokers with AL, former/current smokers without AL, and former/current smokers with AL. Mean IMT, the maximum measurable IMT value in the left and right common carotid arteries (IMT-C max), and mean IMT-C max were measured by carotid ultrasonography. The carotid wall thickness as defined as follows: IMT ≥ 1.1 mm (IMT 1.1 ), IMT-C max ≥ 1.2 mm (IMTc 1.2 ), and IMT-C max > 1.5 mm (IMTc 1.5 ), based on each measured region. The association between AL and the carotid wall thickness according to smoking status was assessed by logistic regression analysis. Results The mean carotid IMT and mean IMT-C max were significantly higher in never smokers with AL and former/current smokers with or without AL than in never smokers without AL. In logistic regression models adjusted for sex, age, body mass index, hypertension, dyslipidemia, hyperglycemia, physical activity, and alcohol consumption, the risk of carotid wall thickness (IMT 1.1 [odds ratio {OR}: 1.55; 95% confidence interval {CI}: 1.07–2.24]; IMTc 1.2 [OR: 1.52; 95% CI: 1.03–2.24]; IMTc 1.5 [OR: 1.99; 95% CI: 1.15–3.46]) were significantly higher in former/current smokers with AL than in never smokers without AL. Conclusion The present results suggest that greater IMT and risk of carotid wall thickness were associated with AL and smoking experience.

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Close Association between Subclinical Atherosclerosis and Pulmonary Function in Middle-Aged Male Smokers

Cited by 8 publications

References 55 publications

Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals

Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals

Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study

Association Between Airflow Limitation and Carotid Intima-Media Thickness in the Japanese Population

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