Associations of telomere length with anthropometric and glucose changes after a lifestyle intervention in abdominal obese children

Morell‐Azanza, Lydia; Ojeda‐Rodríguez, Ana; Azcona, Cristina; Zalba, Guillermo; Marti, Amelia

doi:10.1016/j.numecd.2019.12.002

Cited by 13 publications

(22 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with previous studies in paediatric populations ,5,9,54 we found a negative association between TL and age at baseline and at 2 months. However, the relatively small sample size or the effects of the intervention could favour the lack of relationship between TL and age after 12 months of lifestyle intervention 8 …”

Section: Discussionsupporting

confidence: 93%

“…This study demonstrates the beneficial effects of a lifestyle intervention in paediatric subjects with obesity, in line with studies performed in children and adolescents with a similar age range 6‐17 included in two Cochrane systematic reviews 44,45 . It is worth to highlighting that a decrease of more than 0.25 in BMI‐SDS did reduce cardiovascular risk factors 46 .…”

Section: Discussionsupporting

confidence: 81%

“…Shorter TL have been reported in children with obesity compared with children without obesity 5‐7 which could be linked with low‐grade systemic inflammation. Notably, in previous studies, we 8,9 and others 10 have shown associations between TL and changes in adiposity indices or metabolic features (glucose levels 8,9 ).…”

Section: Introductionmentioning

confidence: 59%

“…The relationship between obesity and TL is not fully understood 5‐9 . Shorter TL have been reported in children with obesity compared with children without obesity 5‐7 which could be linked with low‐grade systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Dietary factors seem to influence telomere length. Moreover, associations between changes in adiposity indices and telomere length (TL) have been found in intervention studies. Objective: We evaluated changes in two diet quality indices and their association with TL in children with abdominal obesity in a 12-month lifestyle intervention. Methods: Eighty-seven participants (7-16 years old) were assigned to the intervention (moderate hypocaloric Mediterranean diet) or usual care group (standard paediatric recommendations) for a 2-month intensive phase and a subsequent 10-month follow-up. Diet quality was assessed using the Diet Quality Index for Adolescents (DQI-A) and the Healthy Lifestyle Diet Index (HLD-I). TL was measured by monochrome multiplex real-time quantitative PCR. The intra-class correlation coefficient for TL was 0.793 (95% CI 0.707, 0.857). Results: After a 12-month lifestyle intervention, a significant reduction in BMI-SDS (−0.57 and −0.49 for the intervention and usual care groups, respectively) and fat mass was observed in all subjects without differences between groups. Changes in DQI-A (+12.36% vs +5.53%, P = .005) and HLD-I (+4.43 vs +1.09, P < .001) were higher in the intervention subjects compared with usual care subjects after 2 months. Interestingly, we observed a positive change in TL between 2 and 12 months (P = .025), which was associated with higher scores on the DQI-A

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Telomere length did not change but was a predictor for changes in blood glucose levels after this lifestyle intervention. 46 When discussing these results, it is necessary to note that it has not been indicated what kind of exercise was used in the study. In addition, in the Norwegian study, longer telomeres were obtained in older endurance trained athletes compared to those in older people with a medium activity level, while telomere length of young endurance trained athletes was not different than young non-athletes.…”

Section: Telomere Length Modification: Lifestyle and Medication Factorsmentioning

confidence: 99%

Telomere length in different metabolic categories: Clinical associations and modification potential

Khalangot

Krasnienkov

Vaiserman

2020

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Cardio-metabolic disorders, including type 2 diabetes, are known to be associated with accelerated attrition of telomeres, recognized as genetic and biological markers of aging. Some common genetic characteristics were found regarding the presence of shorter telomeres and the development of type 2 diabetes. However, there are conflicting epidemiological reports regarding the association of leukocyte telomeres lengths with type 2 diabetes: not only the causality of such a link remains unclear, but not all researchers acknowledge its existence. The link between current trends in life expectancy of people with type 2 diabetes and the increase in the number of people with type 2 diabetes raises interest in the question of the possibility of drug or life-style-related modification of leukocyte telomeres length. To address the question how leukocyte telomeres lengths are associated with glucose levels in hyperglycemic categories, we examined the correlations between leukocyte telomeres length and fasting plasma glucose and 2 h post-load plasma glucose levels (2hPG). Our data indicate that leukocyte telomeres length is negatively related to 2hPG and the relationship with increasing of fasting plasma glucose may be non-linear. Remarkably, the negative association between leukocyte telomeres length and age was demonstrated in our research only for individuals with normal fasting plasma glucose levels, but not for those with high fasting plasma glucose levels. The nonlinear nature of interactions between age and 2hPG level has been demonstrated by artificial neural networks modeling when investigating the links between leukocyte telomeres length and metabolic syndrome. Thus, it can be assumed that relationships between leukocyte telomeres length and FPG/2hPG levels are not the same, and this distinction can potentially be used in categorization of metabolic disorders. It is possible that these data along with reports of the possibility of modifying leukocyte telomeres length can improve the understanding of present-day epidemiological trends in type 2 diabetes incidence and mortality. Impact statement Metabolic disorders are known to be associated with accelerated telomere attrition. Their pathophysiological heterogeneity suggests the importance of multiple tests in examining these associations. However, oral glucose tolerance test (OGTT) has rarely been performed in such studies to date. There are few studies aimed at determining leukocyte telomere length (LTL) in different categories of impaired glucose tolerance (IGT), and those that do exist do not take into account the impaired fasting glucose (IFG)/IGT categorization. Therefore, we believe our study, when the OGTT was used, is important to the field. This testing made it possible to determine whether LTLs are associated with glucose levels in different hyperglycemic categories. Our data indicate that relationships between LTLs and IFG/IGT levels are not the same. This distinction can potentially be used in categorization of metabolic disorders and in determining the effectiveness of interventions aimed at treating diabetes and other metabolic abnormalities.

show abstract

Leukocyte telomere length is inversely associated with a metabolic risk score in Mesoamerican children

Garfein

Flannagan

Rittman

et al. 2021

American J Hum Biol

View full text Add to dashboard Cite

Objective Leukocyte telomere length (LTL) may be involved in the etiology of the metabolic syndrome (MetS). We examined the associations of LTL with MetS and its components among Mesoamerican children and their adult parents, in a region where MetS prevalence is high. Methods We conducted a cross‐sectional study of 151 children aged 7–12 years and 346 parents from the capitals of Belize, Honduras, Nicaragua, Costa Rica, Panama, and Chiapas State, Mexico. We quantified LTL by qPCR on DNA extracted from whole blood. In children, we created an age‐ and sex‐standardized metabolic risk score using waist circumference (WC), the homeostasis model of insulin resistance (HOMA‐IR), blood pressure, serum high‐density lipoprotein (HDL) cholesterol, and serum triglycerides. In adults, MetS was defined according to the National Cholesterol Education Program's Adult Treatment Panel III definition. We estimated mean differences in metabolic risk score and prevalence ratios of MetS across quartiles of LTL using multivariable‐adjusted linear and Poisson regression models, respectively. Results In children, every 1 LTL z‐score was related to an adjusted 0.05 units lower (95% CI: −0.09, −0.02, P = 0.005) MetS risk score, through WC, HOMA‐IR, and HDL. Among adults, LTL was not associated with MetS prevalence; however, every 1 LTL z‐score was associated with an adjusted 34% lower prevalence of high fasting glucose (95% CI: 3%, 55%, p = .03). Conclusions Among Mesoamerican children, LTL is associated with an improved metabolic profile; among adults, LTL is inversely associated with the prevalence of high fasting glucose.

show abstract

Associations of telomere length with anthropometric and glucose changes after a lifestyle intervention in abdominal obese children

Cited by 13 publications

References 37 publications

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

Telomere length in different metabolic categories: Clinical associations and modification potential

Leukocyte telomere length is inversely associated with a metabolic risk score in Mesoamerican children

Contact Info

Product

Resources

About