Telomere length in different metabolic categories: Clinical associations and modification potential

Abstract

Cardio-metabolic disorders, including type 2 diabetes, are known to be associated with accelerated attrition of telomeres, recognized as genetic and biological markers of aging. Some common genetic characteristics were found regarding the presence of shorter telomeres and the development of type 2 diabetes. However, there are conflicting epidemiological reports regarding the association of leukocyte telomeres lengths with type 2 diabetes: not only the causality of such a link remains unclear, but not all researchers acknowledge its existence. The link between current trends in life expectancy of people with type 2 diabetes and the increase in the number of people with type 2 diabetes raises interest in the question of the possibility of drug or life-style-related modification of leukocyte telomeres length. To address the question how leukocyte telomeres lengths are associated with glucose levels in hyperglycemic categories, we examined the correlations between leukocyte telomeres length and fasting plasma glucose and 2 h post-load plasma glucose levels (2hPG). Our data indicate that leukocyte telomeres length is negatively related to 2hPG and the relationship with increasing of fasting plasma glucose may be non-linear. Remarkably, the negative association between leukocyte telomeres length and age was demonstrated in our research only for individuals with normal fasting plasma glucose levels, but not for those with high fasting plasma glucose levels. The nonlinear nature of interactions between age and 2hPG level has been demonstrated by artificial neural networks modeling when investigating the links between leukocyte telomeres length and metabolic syndrome. Thus, it can be assumed that relationships between leukocyte telomeres length and FPG/2hPG levels are not the same, and this distinction can potentially be used in categorization of metabolic disorders. It is possible that these data along with reports of the possibility of modifying leukocyte telomeres length can improve the understanding of present-day epidemiological trends in type 2 diabetes incidence and mortality. Impact statement Metabolic disorders are known to be associated with accelerated telomere attrition. Their pathophysiological heterogeneity suggests the importance of multiple tests in examining these associations. However, oral glucose tolerance test (OGTT) has rarely been performed in such studies to date. There are few studies aimed at determining leukocyte telomere length (LTL) in different categories of impaired glucose tolerance (IGT), and those that do exist do not take into account the impaired fasting glucose (IFG)/IGT categorization. Therefore, we believe our study, when the OGTT was used, is important to the field. This testing made it possible to determine whether LTLs are associated with glucose levels in different hyperglycemic categories. Our data indicate that relationships between LTLs and IFG/IGT levels are not the same. This distinction can potentially be used in categorization of metabolic disorders and in determining the effectiveness of interventions aimed at treating diabetes and other metabolic abnormalities.

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

“…An association of short LTL with higher risk for developing type 2 diabetes has been also demonstrated; this association, however, was significantly influenced by body mass index (BMI), diabetes type, age, region, and sex (Zhao et al, 2013 ; Willeit et al, 2014 ; Wang et al, 2016 ; Krasnienkov et al, 2018 ). Short LTL was also shown to be associated with different aspects of metabolic syndrome (Khalangot et al, 2017 , 2019 , 2020 ). Accelerated telomere shortening and low telomerase activity were shown to be associated with skeletal pathologies mediated by the age-related abnormal reconstruction of the subchondral bone, such as osteoporosis and osteoarthritis (Fragkiadaki et al, 2020 ).…”

Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes

“…Previous studies have reported hypoadiponectinemia to act as a biomarker for insulin resistance and an independent risk factor for cardiovascular diseases and T2DM [ 52 ]. Other determinants that have been linked to an increased rate of TL shortening as well as increased cardiovascular risk include obesity, hypertension, deranged fasting plasma glucose, and high triglyceride with or without low HDL levels [ 53 ]. Our data align with a recent study undertaken in a multiethnic Asian population, which reported ethnic variation in the association between obesity indices (BMI and visceral fat area) and short TL in T2DM patients [ 54 ].…”

Telomere length in individuals with early pregnancy losses

“…Жінки, що перенесли втрати вагітності, зазнають стресу, через що порушуються функції цілого організму [7,9,15,16]. Вони також мають підвищений ризик кардіоваскулярних захворювань [14], які, як відомо, асоціюються із короткими теломерами [4,6]. Отже, довжина теломер є суттєво меншою у жінок із ранніми репродуктивними втратами.…”