Associations of SNPs located at candidate genes to bovine growth traits, prioritized with an interaction networks construction approach

Abstract

BackgroundFor most domestic animal species, including bovines, it is difficult to identify causative genetic variants involved in economically relevant traits. The candidate gene approach is efficient because it investigates genes that are expected to be associated with the expression of a trait and defines whether the genetic variation present in a population is associated with phenotypic diversity. A potential limitation of this approach is the identification of candidates. This study used a bioinformatics approach to identify candidate genes via a search guided by a functional interaction network.ResultsA functional interaction network tool, BosNet, was constructed for Bos taurus. Predictions for candidate genes were performed using the guilt-by-association principle in BosNet. Association analyses identified five novel markers within BosNet-prioritized genes that had significant effects on different growth traits in Charolais and Brahman cattle.ConclusionsBosNet is an excellent tool for the identification of single nucleotide polymorphisms that are potentially associated with complex traits.

Frecuencia de SNP en genes candidatos para crecimiento y su efecto en caracteres de peso vivo en ganado para carne de Tamaulipas

“…Diferentes estudios realizados en hatos de ganado de la raza Charolais en México han mostrado asociación entre algunos marcadores moleculares localizados en estos genes candidatos (2,12,13) . Sin embargo, es muy importante considerar que el patrón de asociación de estos marcadores es ampliamente variable entre las razas y aún más entre las poblaciones; por lo que es necesaria su evaluación antes de implementarse dentro de los esquemas de selección y mejoramiento genético.…”

Asociación entre marcadores genéticos capn-1, cast y características de crecimiento en ganado brahman en Costa Rica1

“…Las características de calidad de la carne se encuentran influenciadas por factores genéticos y ambientales (Soria y Corva 2004) que definen los rasgos en el animal. La predicción de rasgos en el animal, por medio de la genética molecular (Casas et al 2011), es un tema de investigación de vanguardia para la producción vacuna, donde la detección de las variables involucradas en los rasgos económicamente relevantes, es una necesidad para la optimización del sistema productivo y donde características de calidad de carne como marmoleo, color, capacidad de retención de agua, se encuentran influenciadas por factores genéticos (Li et al 2013, Paredes-Sánchez et al 2015.…”

Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle

“…Some of them include the bovine growth hormone (bGH), associated with carcass fat content and muscle yield, milk yield, and testicular development (Yao et al, 1996;Unanian et al, 2002); the receptor of bGH, associated with a large number of productive traits such as milk yield and composition (Viitala et al, 2006), feed consumption, and feed conversion efficiency (Banos et al, 2008); and the bGH releasing hormone associated with carcass traits (Cheong et al, 2006). From an interactive network, some of these candidate genes, although not directly related to a determined trait, can have an indirect physiological relationship leading to significant enhancement of a correlated response in another trait (Paredes-Sánchez et al, 2015). Different variants of casein have been related to milk yield and composition and protein content (Caroli et al, 2009).…”