Associations of single nucleotide polymorphisms in the bovine prolactin gene with phenotypic traits in beef cattle

Meyer, Laura; Powell, J. G.; Kutz, B. R.; Looper, M. L.; Brown, A.H.; Rosenkrans, C. F.

doi:10.1016/j.aggene.2017.06.002

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Our obtained results finding the GG genotype at the PRL locus more prevalent than the AG and AA genotypes in RS cattle, and the higher frequency of the G allele compared to the A allele in both investigated breeds were also confirmed in Holstein Friesian cattle, crossbred Angus-based cows, and Iranian Holstein [10,16,25], although none of those studies found a lack of the AA genotype in the investigated populations and such a large range of variation in terms of genotype frequencies as we found in the RS cattle population.…”

Section: Discussionsupporting

confidence: 72%

“…Moreover, the results obtained by Thuy et al [16] highlighted no significant differences between the cows of different genotypes, where cows with the PP genotype (i.e., the GG genotype in our study) produced more milk compared to those with PC (AG) and CC (AA) genotypes. In a cited study by Meyer et al [25], the homozygous GG cows were reported with more fat content, and the heterozygous (AG) cows had increased milk yield, results which correspond only with those obtained by us in the case of the superiority of the AG genotype for milk production in RB cattle.…”

Section: Discussionmentioning

confidence: 52%

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Polymorphism of the Prolactin (PRL) Gene and Its Effect on Milk Production Traits in Romanian Cattle Breeds

Ilie

Mizeranschi

Míhali

et al. 2023

Veterinary Sciences

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In the present study, we investigated one polymorphism of the PRL gene (rs211032652 SNP) and assessed its influence on milk production and chemical composition in two Romanian cattle breeds. A total of 119 cattle from two breeds reared in Western Romania (64 Romanian Spotted and 55 Romanian Brown) were included in the research herd. A PCR-RFLP genotyping assay was used for the identification of the rs211032652 SNP variants. Shapiro’s test and Levene’s test were used to verify ANOVA assumptions and ANOVA and Tukey’s test were employed to test the associations between PRL genotypes and five milk traits. Among the studied breeds, our results showed that PRL genotypes were significantly associated (p < 0.05) with fat and protein percentage in the milk of Romanian Brown cattle. The AA genotype was associated with a higher fat percentage in milk (4.76 ± 0.28) compared to the GG genotype (4.04 ± 0.22, p = 0.048), as well as a higher protein percentage (3.96 ± 0.32% vs. 3.43 ± 0.15%, p = 0.027) in Romanian Brown cattle. Moreover, the PRL locus favored a significantly higher fat (p = 0.021) and protein (p = 0.028) percentage in the milk of Romanian Brown cattle compared to the Romanian Spotted breed, with a difference of 0.263% and 0.170%, respectively.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 52%

Polymorphism of the Prolactin (PRL) Gene and Its Effect on Milk Production Traits in Romanian Cattle Breeds

Ilie

Mizeranschi

Míhali

et al. 2023

Veterinary Sciences

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“…The GDNF gene is related to important functions in skin homeostasis and hair cycle control [ 38 ]. PRLR is extensively described as important for milk traits in dairy cows [ 39 , 40 ], and polymorphisms in the PRLR are associated with calving rates in beef cattle [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Selective signatures in composite MONTANA TROPICAL beef cattle reveal potential genomic regions for tropical adaptation

Santos,

Eler,

Oliveira

et al. 2024

PLoS ONE

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Genomic regions related to tropical adaptability are of paramount importance for animal breeding nowadays, especially in the context of global climate change. Moreover, understanding the genomic architecture of these regions may be very relevant for aiding breeding programs in choosing the best selection scheme for tropical adaptation and/or implementing a crossbreeding scheme. The composite MONTANA TROPICAL® population was developed by crossing cattle of four different biological types to improve production in harsh environments. Pedigree and genotype data (51962 SNPs) from 3215 MONTANA TROPICAL® cattle were used to i) characterize the population structure; ii) identify signatures of selection with complementary approaches, i.e. Integrated Haplotype Score (iHS) and Runs of Homozygosity (ROH); and iii) understand genes and traits related to each selected region. The population structure based on principal components had a weak relationship with the genetic contribution of the different biological types. Clustering analyses (ADMIXTURE) showed different clusters according to the number of generations within the composite population. Considering results of both selection signatures approaches, we identified only one consensus region on chromosome 20 (35399405–40329703 bp). Genes in this region are related to immune function, regulation of epithelial cell differentiation, and cell response to ionizing radiation. This region harbors the slick locus which is related to slick hair and epidermis anatomy, both of which are related to heat stress adaptation. Also, QTLs in this region were related to feed intake, milk yield, mastitis, reproduction, and slick hair coat. The signatures of selection detected here arose in a few generations after crossbreeding between contrasting breeds. Therefore, it shows how important this genomic region may be for these animals to thrive in tropical conditions. Further investigations on sequencing this region can identify candidate genes for animal breeding and/or gene editing to tackle the challenges of climate change.

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“…For beef cattle, Meyer et al (15) associated polymorphisms present in the bovine prolactin (Prl) gene with other phenotypic characteristics, and found six haplotypes for the bovine Prl gene, with emphasis on the CAG haplotype. Animals had higher birth rates (96, 91, 90, 81, 86, and 81%) and higher pregnancy rates (43.4, 42.7, 42.8, 42.8, 40.8, and 37.7%, p<0.05) when they presented this haplotype.…”

Section: Single Nucleotide Polymorphism (Snp) Markersmentioning

confidence: 99%

Association between somatotropic axis gene polymorphisms and reproductive efficiency of bovine females: a review

et al. 2022

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Reproductive characteristics directly reflect on productive performance, as they determine the number of calves born annually and the interval between generations, thereby affecting the selection intensity. This allows for the determination of the most important economic variables that directly affect the production system. The present study is a literature review of somatotropic axis gene polymorphisms that are associated with reproductive functions in heifers and cows (Bos taurus taurus and Bos taurus indicus). The following characteristics were analyzed from the various studies reviewed: number of services per pregnancy (Nº services/ pregnancy), age at first calving (AFC), calving interval (CI), and period of service calving conception interval (CCI). The research was conducted during the period from 2011 to 2021, and associations were found among all indicators of reproductive efficiency evaluated in heifers and cows, with 27 single nucleotide polymorphisms (SNPs): 18 in GHR, 5 in IGF-I, and 4 in STAT5A. This study revealed the relationships between SNPs and the reproductive efficiency indicators and demonstrated that molecular genetic techniques enhance the animal selection process, resulting in more profitable systems that are sustainable in the long term.

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Associations of single nucleotide polymorphisms in the bovine prolactin gene with phenotypic traits in beef cattle

Cited by 6 publications

References 22 publications

Polymorphism of the Prolactin (PRL) Gene and Its Effect on Milk Production Traits in Romanian Cattle Breeds

Polymorphism of the Prolactin (PRL) Gene and Its Effect on Milk Production Traits in Romanian Cattle Breeds

Selective signatures in composite MONTANA TROPICAL beef cattle reveal potential genomic regions for tropical adaptation

Association between somatotropic axis gene polymorphisms and reproductive efficiency of bovine females: a review

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