Associations of Single Nucleotide Polymorphism in miR-146a Gene with Susceptibility to Breast Cancer in the Iranian Female

Siasi, Elham; Solimani, Mahkameh

doi:10.31557/apjcp.2020.21.6.1585

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…In recent years, numerous studies have investigated the associations between SNPs in miRNA genes and the risks of various types of cancer [25][26][27][28][29][30]. Although conflicting and inconsistent results have been obtained, the differences in association among studies may be due to different dietary habits, environmental exposures, and most importantly, different genetic background among the various study populations.…”

Section: Discussionmentioning

confidence: 99%

Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan

Wang,

Chang,

Liao

et al. 2023

Biomedicines

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The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in mir146a and mir196a and bladder cancer (BLCA) risk in Taiwan. The genotypes of mir146a rs2910164 and mir196a rs11614913 were determined in 375 BLCA patients and 375 healthy controls using PCR-RFLP methodology, and their associations with BLCA risk were evaluated. The study also measured the serum expression level of mir146a using quantitative RT-PCR. The results showed that the distributions of CC, CG and GG genotypes of mir146a rs2910164 were 31.7%, 45.6% and 22.7% in the control group, and 21.9%, 44.3% and 33.8% in the case group, respectively. In logistic regression analyses, the heterozygous variant genotype CG carriers showed a marginally significant association with increased BLCA risk (OR = 1.41, 95% CI = 0.99–2.01), while the homozygous variant genotype GG carriers had a 2.17-fold increased risk of BLCA (OR = 2.17, 95%CI = 1.46–3.21). Moreover, carriers of the GG/CG genotypes had significantly higher serum levels of mir146a than those with the CC genotype (p < 0.0001), indicating a genotype–phenotype correlation. In contrast, mir196a rs11614913 was not associated with BLCA risk. Therefore, the genotypes of mir146a rs2910164 may serve as a useful biomarker for predicting the risk of BLCA.

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Section: Discussionmentioning

confidence: 99%

Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan

Wang,

Chang,

Liao

et al. 2023

Biomedicines

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“…Several reports have shown no associations between BC risk and rs2910164 [16][17][18][19][20][21][22] and rs11614913 [18,19,[23][24][25] in most diverse populations. On the contrary, the miR-164a rs2910164 was reported as susceptible to BC in 300 Pakistani females [26] (Tables 3, 4).…”

Section: Discussionmentioning

confidence: 99%

Prospective Functions of miRNA Variants May Predict Breast Cancer Among Saudi Females

Ekram,

Alghamdi,

Elhawary

et al. 2023

Cureus

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Background Growing knowledge supports the importance of microRNAs (miRNAs) in modulating the initiation and development of breast cancer (BC) and underlying mechanisms. BC is a significant public health in females worldwide, where it remains the leading cause of death among Saudi females. Here, we evaluate the susceptibility of the miRNA genetic variants to the risk of BC in Saudi females. Methods One hundred fifty-four females, including 76 females diagnosed with BC and 78 healthy controls, were analyzed using TaqMan™ (Thermo Fischer Scientific, Waltham, MA) genotyping assays for the miR-196a2 rs11614913 C>T, miR-146a rs2910164 C>G, and miR-499 rs3746444 A>G. We utilized the SNPStats software ( https://www.snpstats.net ) (Institut Català d'Oncologia, Barcelona, Spain) to choose the best interactive inheritance model for the examined miRNAs. Results The examined miRNA single-nucleotide polymorphisms (SNPs) showed no clear association with the risk of BC (P > 0.05). As for genotypic distributions, significant associations were found for the rs2910164 SNP in most interactive models of inheritance: 2.50 (95% confidence interval {CI}, 1.2-5.17; P = 0.0135) in the codominant model, 2.34 (95% CI, 1.11-4.8; P = 0.0197) in the dominant model, and 2.40 (95% CI, 1.22-4.73; P = 0.0113) in overdominant model. The rs2910164 C/G heterozygosity showed overexpression in cases compared to controls (73.7% versus 53.9%; chi-squared (χ 2 ) = 6.5; P = 0.0109), but the homozygous rs2910164 G/G showed a significant protective effect (21.1% versus 38.5%; χ 2 = 17.4; P = 0.019). The heterozygosity did not affect the risk to the BC in the two miRNAs (rs11614913 C>T and rs3746444 A>G). Conclusion Despite lacking associations with the examined miRNAs, the heterozygous genotype rs2910164 C/G can identify at-risk females. More studies should be replicated using a panel of miRNA genes to discover significant associations with the risk of BC.

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“…In recent years, investigating the expression of miRNAs, and their association with risk for various types of cancer, has become a research interest for many scientists [25][26][27][28][29][30] . Although con icting and inconsistent results were obtained, the differences in the association among studies may be due to different dietary, habits, environmental exposures, and most of all, different genetic background among the various study populations.…”

Section: Discussionmentioning

confidence: 99%

Impacts of mir146a genotypes to bladder cancer risk in Taiwan

Chang¹,

Liao

Chen³

et al. 2022

Preprint

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We aimed to examine the associations of the genotypes for mir146a and mir196a with bladder cancer (BLCA) risk in Taiwan. Mir146a rs2910164 and mir196a rs11614913 genotypes among 375 bladder cancer patients and 375 healthy subjects were determined using the typical PCR-RFLP methodology, and their associations and interactions with age, gender, smoking and alcohol drinking status on BLCA risk were evaluated. Simultaneously, the serum expression level of mir146a was measured using quantitative RT-PCR. The results showed that the partitions of CC, CG and GG of mir146a genotypes were 31.7, 45.6 and 22.7% in the control group and 21.9, 44.3 and 33.8% in the case group, respectively. In logistic regression analysis, the heterozygous variant genotype CG carriers were at a bolder line significantly increased BLCA risk (OR = 1.41, 95% CI = 0.99–2.01) and the homozygous variant GG carriers were at a 2.17-fold increased BLCA risk (OR = 2.17, 95%CI = 1.46–3.21). Moreover, the GG/CG genotype carriers have significantly higher serum levels of mir146a than the CC genotype (p < 0.0001), supporting a genotype-phenotype correlation. The mir196a rs11614913 SNP were not associated with BLCA risk. In conclusion, genotypes of mir146a rs2910164 may serve as a risk prediction marker for BLCA.

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Associations of Single Nucleotide Polymorphism in miR-146a Gene with Susceptibility to Breast Cancer in the Iranian Female

Cited by 5 publications

References 37 publications

Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan

Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan

Prospective Functions of miRNA Variants May Predict Breast Cancer Among Saudi Females

Impacts of mir146a genotypes to bladder cancer risk in Taiwan

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