Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study

Abstract

Background The objective of this study was to investigate the relationships between atopic dermatitis (AD) and other common chronic health conditions in adults. Methods A cross-sectional survey was sent to a randomly selected population sample of 78,004 adults in Sweden. The questionnaires included measures of self-reported physical and mental health. Binary and multinomial logistic regression were used to examine the associations of AD with common chronic health conditions and psychological wellbeing. Results AD was self-reported by 4,175 respondents, representing almost 14% of the study population of 34,313 adults. Our results showed positive associations between AD and chronic health disorders, including conditions of the oral cavity: chronic obstructive pulmonary disease (adjusted odds ratio [aOR] = 1.58, 95% confidence interval [CI]: 1.30 to 1.92), asthma (aOR = 2.13, 95% CI: 1.91 to 2.38), mild recurrent gastrointestinal symptoms (adjusted relative risk ratio [aRRR] = 1.78, 95% CI: 1.64 to 1.92), high blood pressure (aOR = 1.16, 95% CI: 1.06 to 1.26), obesity (aOR = 1.34, 95% CI: 1.23 to 1.47), mild joint pain (aRRR = 1.47, 95% CI: 1.35 to 1.61), mild headache or migraine (aRRR = 1.50, 95% CI: 1.38 to 1.64), caries (aOR = 1.25, 95% CI: 1.04 to 1.49), bleeding gums (aOR = 1.69, 95% CI: 1.38 to 2.08), periodontitis (aOR = 1.42, 95% CI: 1.13 to 1.77), sensitive teeth (aOR = 1.57, 95% CI: 1.35 to 1.82), and dry mouth (aOR = 1.52, 95% CI: 1.33 to 1.74). Adjustment for asthma and depression attenuated the magnitude of the associations between AD and the study outcomes. AD was also associated with poorer general psychological wellbeing. Conclusions Adults reporting AD may be at increased risk of chronic disorders and decreased psychological wellbeing. Physicians should recognize that individuals with severe AD and those with comorbid asthma or depression may be especially vulnerable.

Changes in Gut Microbiota of Patients with Atopic Dermatitis During Balneotherapy

“…Not only gut-skin axis, but also gut-brain axis might play a key role in the relation between gut microbiota and AD, patients with AD being at increased risk of psychological wellbeing issues. 58 In our study, we found that 29% of the contrasted functional modules between D0 and D18 were specific to the gut-brain axis modules, whereas they represent only 18% of all considered modules. Among the different modules associated to gut-brain axis, modules related to GABA are of particular interest.…”

Metabolic Comorbidities in Pediatric Atopic Dermatitis: A Narrative Review

“…Arterial hypertension (AH) represents the most common cardiovascular risk factor and is a prevalent comorbidity in adult patients with AD [ 31 ].…”

Type 2 immunity‐driven diseases: Towards a multidisciplinary approach

“…13 In adulthood, a comparable association between AD and asthma can be found. 14 Ethnic background has a differential impact on the expression of those diseases. For example, in AD, the clinical manifestation can be completely different among Asian, African American and European patients.…”

“… 13 In adulthood, a comparable association between AD and asthma can be found. 14 Atopy, another critical phenotypic trait, is defined by the propensity of an individual to develop a specific IgE response against harmless antigens. As a part of AR definition, nasal symptoms need to be consistent with specific IgE production and/or cutaneous prick tests.…”