Associations of Pretreatment Physical Status Parameters with Tolerance of Concurrent Chemoradiation and Survival in Patients with Non-small Cell Lung Cancer

Abstract

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The clinical decision‐making process of healthcare professionals within a personalized home‐based rehabilitation program during sequential chemoradiotherapy for stage III non‐small lung cancer: A case study

“…The pulmonologist independently classified the patient with a WHO performance status of I which indicates a good level of physical function (Voorn et al, 2021). The patient scored a VAS 9 for motivation to the rehabilitation program during CHRT.…”

“…The examination supported the clinical impression that this patient had several risk factors that might be associated with complications during and after treatment. According to previous studies, his advanced age, comorbidities, no maximal effort on the CPET, low HGS, and his impaired nutritional intake at baseline (Table 2) are all independently associated with a high risk for treatment complications (Ozdemir et al, 2020;Voorn et al, 2021). To prevent the patient from intolerance of CHRT which might lead to a delayed treatment, decline in physical functioning, complications, and an impaired recovery of physical functioning after treatment, it is recommended to support the patient to maintain or even improve his physical fitness and nutritional status during CHRT.…”

“…Results of the pretreatment examination are presented in Table 2 and Figure 2 and the most important outcomes are described below. The pulmonologist independently classified the patient with a WHO performance status of I which indicates a good level of physical function (Voorn et al., 2021). The patient scored a VAS 9 for motivation to follow the rehabilitation program during CHRT.…”

“…During these consultations the side effects fatigue and pain were discussed which helped to put these symptoms in the right perspective. The physiotherapist advised to continue the physical exercise training at a lower training intensity, according to the evidence that patients receiving chemotherapy and/or radiation therapy may need to exercise at a lower intensity and/or shorter duration during their treatment (Voorn et al., 2021). While doing exercises in the water, there was an opportunity to share emotions and frustrations with the physiotherapist regarding fatigue, pain, and the intensity of chemotherapy.…”

The Effect Of Body Fat Ratio On Chemotherapy-Induced Nause-Vomiting

“…In non-small cell lung cancer patients, low lean body mass and low BMI as measured by the bioelectrical impedance method have been associated with chemoradiotherapy intolerance (7). Low skeletal muscle mass demonstrated by CT-based body composition measurements has been shown to be a strong predictor of chemotherapy toxicity in early-stage nonmetastatic breast and colorectal cancers (8).…”