Associations of Periodontal Status with General Health Conditions and Serum Antibody Titers for <i>Porphyromonas gingivalis</i> and <i>Actinobacillus actinomycetemcomitans</i>

Furuichi, Yasushi; Shimotsu, Akihiro; Itô, Haruo; Namariyama, Yukari; Yotsumoto, Yukiharu; Hino, Youichi; Mishige, Yukie; Inoue, Masakazu; Izumi, Yuichi

doi:10.1902/jop.2003.74.10.1491

Cited by 28 publications

(35 citation statements)

References 29 publications

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“…Hypertension has been reported to be associated with periodontal disease as latent risks for ischemic heart disease in several studies (7,15,16,20,21) (10,17,18), although we and other investigators (7,15,16,19) …”

Section: T a B L E 2 S P E A R Ma N Co R R E L A T I O N Co E F F Icontrasting

confidence: 58%

“…Periodontal tissue damage may thus be more expected in diabetics with hypercholesteremia, as found in our study. Some (6,9) but not all (7,10,(14)(15)(16)20) previous studies have associated hypercholesteremia with periodontal disease.…”

Section: T a B L E 1 Ch A R A C T E R I S T I C S O F S T U D Y S Umentioning

confidence: 96%

“…Whether atherogenic factors other than hyperglycemia are linked with periodontal damage, however, is still being debated, and previous studies have reported inconsistent results (6)(7)(8)(9)(10)(13)(14)(15)(16)(17)(18)(19)(20)(21) …”

Section: Periodontitis Has Been Referred To As the Sixth Complicationmentioning

confidence: 99%

“…Some reports associated a high level of HDL cholesterol with a lower risk of periodontal disease (7,10) whereas others found no such association (8,(14)(15)(16)20).…”

Section: T a B L E 2 S P E A R Ma N Co R R E L A T I O N Co E F F Imentioning

confidence: 99%

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Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

et al. 2007

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Section: T a B L E 2 S P E A R Ma N Co R R E L A T I O N Co E F F Icontrasting

confidence: 58%

Section: T a B L E 1 Ch A R A C T E R I S T I C S O F S T U D Y S Umentioning

confidence: 96%

Section: Periodontitis Has Been Referred To As the Sixth Complicationmentioning

confidence: 99%

“…Some reports associated a high level of HDL cholesterol with a lower risk of periodontal disease (7,10) whereas others found no such association (8,(14)(15)(16)20).…”

Section: T a B L E 2 S P E A R Ma N Co R R E L A T I O N Co E F F Imentioning

confidence: 99%

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Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

et al. 2007

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“…Del mismo modo, se ha observado que otros patóge-nos periodontales como A. actinomycetemcomitans se han implicado en procesos de endocarditis, posiblemente por su capacidad para adherirse a las válvulas cardíacas lesionadas (13,14).…”

Section: ¿Qué Bacterias Parecen Estar Implicadas?unclassified

Evidencias científicas de la relación entre periodontitis y enfermedades cardiovasculares

Rosado

Marcos

Gómez

2008

Avances en Periodoncia

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Muchos estudios clínicos han investigado la posible asociación entre periodontitis y la enfermedad coronaria. Algunos mantienen una asociación epidemiológica entre ellas y confirman las investigaciones previas que han demostrado que la inflamación periodontal crónica, la infección bacteriana persistente con la presencia de patógenos periodontales, las bolsas periodontales profundas, el número de dientes perdidos y otros marcadores periodontales, parecen ser factores de riesgo importantes para las enfermedades cardiovasculares. Las enfermedades periodontales y cardiovasculares son comunes, y su asociación es muy importante en salud pública. Ambas enfermedades comparten factores de riesgo, tales como la edad, tabaco, stress, estatus socioeconómico y metabolismo de las grasas, por lo que las posibilidades de sesgo son altas.

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Polybacterial challenge effects on cytokine/chemokine production by macrophages and dendritic cells

et al. 2010

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Objective To investigate the polymicrobial infection of periodontal disease, which elicits inflammatory mediators/cytokines/chemokines in the local gingival tissues, and a polybacterial challenge of antigen-presenting cells, e.g. macrophages and dendritic cells (DCs), at the mucosal surface. Materials and methods The cytokine/chemokine profiles of human macrophages and DCs in response to polybacterial challenges were investigated. Results Oral Gram-negative bacteria elicited significantly greater IL-8 levels from macrophages, compared to Gram-positive bacteria. Gram-positive bacteria did not show synergism in inducing this chemokine from macrophages. In contrast, pairs of oral Gram-negative bacteria elicited synergistic production of IL-8 by macrophages. Similar results were not observed with TNFα, which only appeared additive with the polybacterial challenge. Selected Gram-negative bacterial pairs synergized in IL-6 production by immature DCs. In mature DCs (mDCs), a Porphyromonas gingivalis/Fusobacterium nucleatum and Porphyromonas intermedia/F. nucleatum polybacterial challenge resulted in significant synergism for IL-6 and TNFα levels. However, only the Pi/Fn combination synergized for IL-12 production and there appeared to be no polybacterial effect on IL-10 production by the mDCs. Conclusions These results indicate that a polybacterial challenge of cells linking innate and adaptive immune responses results in varied response profiles that are dependent upon the characteristics of the microorganisms that are components of the polybacterial complex.

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Associations of Periodontal Status with General Health Conditions and Serum Antibody Titers for Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans

Cited by 28 publications

References 29 publications

Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

Evidencias científicas de la relación entre periodontitis y enfermedades cardiovasculares

Polybacterial challenge effects on cytokine/chemokine production by macrophages and dendritic cells

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