The DONuT experiment collected data in 1997 and published first results in 2000 based on four observed ντ charged-current (CC) interactions. The final analysis of the data collected in the experiment is presented in this paper, based on 3.6 × 10 17 protons on target using the 800 GeV Tevatron beam at Fermilab. The number of observed ντ CC interactions is 9, from a total of 578 observed neutrino interactions. We calculated the energy-independent part of the tau-neutrino CC cross section (ν +ν), relative to the well-known νe and νµ cross sections. The ratio σ(ντ )/σ(νe,µ) was found to be 1.37±0.35±0.77. The ντ CC cross section was found to be 0.72±0.24±0.36×10 −38 cm 2 GeV −1 . Both results are in agreement with expectations from the Standard Model.
BackgroundIt is unclear whether health related quality of life (HRQL) may have a predictive value for mortality in idiopathic pulmonary fibrosis (IPF).We investigated the relationship between HRQL assessed using the St. George’s Respiratory Questionnaire (SGRQ) and survival time in patients with IPF, and tried to determine a clinical meaningful cut off value to predict poorer survival rates.MethodsWe retrospectively analyzed consecutive patients with IPF who underwent an initial evaluation from May 2007 to December 2012. The diagnosis of IPF was made according to the 2011 international consensus guidelines. We used Cox proportional hazard models to identify independent predictors for mortality rate in patients with IPF.ResultsWe examined 182 eligible cases, average age was 66 years old, and 86% were male. Mean levels of percent predicted FVC, DLco, six-minute-walk test distance, and the SGRQ total score were around 80%, 58%, 580 m, and 34 points. On multivariate analysis, the SGRQ total score (hazard ratio [HR], 1.012; 95% confidence interval [CI] 1.001–1.023; P = .029) and percent predicted FVC (HR, 0.957; 95% CI 0.944–0.971, P < .001) were independent predictors for mortality rate. Moreover, a score higher than 30 points in the SGRQ total score showed higher mortality rate (HR, 2.047; 95% CI, 1.329–3.153; P = .001).ConclusionsThe SGRQ total score was one of independent prognostic factors in patients with IPF. Total scores higher than 30 points were associated with higher mortality rates.Trial registrationThis study was retrospective, observational study, so it is not applicable.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-017-0503-3) contains supplementary material, which is available to authorized users.
The CAT is a valid health status measurement in IPF patients. Multiple regression analysis showed that the CAT was significantly correlated with dyspnoea severity, oxygenation impairment and anxiety.
computed tomography (ct) assessment of the cross-sectional area of the erector spinae muscles (eSM cSA ) can be used to evaluate sarcopenia and cachexia in patients with lung diseases. This study aimed to confirm whether serial changes in ESM cSA are associated with survival in patients with idiopathic pulmonary fibrosis (IPF). Data from consecutive patients with IPF who were referred to a single centre were retrospectively reviewed. We measured the ESM cSA at the level of the 12th thoracic vertebra on CT images at referral and 6 months later (n = 119). The follow-up time was from 817-1633 days (median, 1335 days) and 59 patients (49.6%) died. A univariate Cox regression analysis showed that the decline in % predicted forced vital capacity (FVC) (Hazard ratios [HR] 1.041, 95% confidence interval [CI] 1.013-1.069, P = 0.004), the decline in body mass index (BMI) (HR 1.084, 95% CI 1.037-1.128; P < 0.001) and that in ESM cSA (HR 1.057, 95% CI 1.027-1.086; P < 0.001) were prognostic factors. For multivariate analyses, the decline in ESM cSA (HR 1.039, 95% CI 1.007-1.071, P = 0.015) was a significant prognostic factor, while those in % FVC and BMI were discarded. Early decrease in ESM cSA may be a useful predictor of prognosis in patients with IPF.
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