Associations of perchlorate, nitrate, and thiocyanate with metabolic syndrome and its components among US adults: A cross-sectional study from NHANES

Guo, Xianwei; Wu, Birong; Hu, Wenjing; Wang, Xingyue; Su, Weiyi; Meng, Jian; Lowe, Scott W.; Zhao, Dongdong; Huang, Christy; Liang, Mingming; Qu, Guangbo; Zhou, Xiaoqin; Sun, Yehuan

doi:10.1016/j.scitotenv.2023.163083

Cited by 10 publications

(6 citation statements)

References 62 publications

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“…The findings will vary depending on particular approaches because these statistical techniques place varying emphasis on handling distinct statistical characteristics (high dimensionality, multicollinearity, interaction, and nonlinear effects). Combining different statistical approaches can help provide reasonably comprehensive information and avoids the one-sidedness of a single approach [ 45 ]. Nevertheless, additional study is required to address mixture and interaction effects using statistical methods and to clarify biological processes due to the intricacy of the real environmental effects of multiple metals.…”

Section: Discussionmentioning

confidence: 99%

Sex Specificity in the Mixed Effects of Blood Heavy Metals and Cognitive Function on Elderly: Evidence from NHANES

et al. 2023

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The way that males and females react to environmental exposures and negative impacts on their neurological systems is often different. Although previous research has examined the cognitively impairing effects of solitary metal exposures, the relationship between metal mixtures and cognitive function, particularly when considering an individual’s sex, remains elusive. This study aimed to investigate the sex differences in the association between multiple metal combinations and cognitive function in older Americans. This research employed the 2011–2014 NHANES survey of elderly Americans. The association between five mixed metals and four cognitive tests (the animal fluency test (AFT), the digit symbol substitution test (DSST), the instant recall test (IRT), and the delayed recall test (DRT)) were investigated with generalized linear regression model (GLM), Bayesian kernel machine regression model (BKMR), weighted quantile sum regression model (WQS), and quantile g-computation regression model (Qgcomp). A total of 1833 people, including 883 males and 950 females, enrolled in this cross-sectional study. We discovered that blood lead and blood cadmium were negatively associated with cognitive performance, while blood selenium demonstrated a positive association with cognitive function in older people. The negative relationship of heavy metal combinations on cognitive function might be somewhat reduced or even reversed via selenium. The IRT, AFT, and DSST are three of the four cognitive tests where men had more dramatic positive or negative results. There was a sex-specific connection between blood metal ratios and cognitive function among older Americans, as evidenced by the more significant relationship between mixed metals and cognitive performance in men (either positively or negatively). These results emphasize the impacts of ambient heavy metal exposure on cognitive function by employing sex-specific methods.

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Section: Discussionmentioning

confidence: 99%

Sex Specificity in the Mixed Effects of Blood Heavy Metals and Cognitive Function on Elderly: Evidence from NHANES

et al. 2023

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“…In our analysis, blood Mg and Cu were positively associated with SUA, while blood Mn showed a negative relationship. WQS regression, on the other hand, is capable of assessing the overall effect and contribution of each exposure by estimating the weight of individual metals ( 48 , 49 ). For instance, the combined effect of mixed metal elements was positively linked to SUA [β = 13.59 (95%CI: 5.57, 21.60)].…”

Section: Discussionmentioning

confidence: 99%

Associations between blood essential metal mixture and serum uric acid: a cross-sectional study

Wang,

Li,

Duan

et al. 2023

Front. Public Health

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IntroductionAlthough several studies have explored the associations between single essential metals and serum uric acid (SUA), the study about the essential metal mixture and the interactions of metals for hyperuricemia remains unclear.MethodsWe performed a cross-sectional study to explore the association of the SUA levels with the blood essential metal mixture, including magnesium (Mg), calcium (Ca), iron (Fe), copper (Cu), zinc (Zn), manganese (Mn) in Chinese community-dwelling adults (n=1039). The multivariable linear regression, the weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) were conducted to estimate the associations of blood essential metals with SUA levels and the BKMR model was also conducted to estimate the interactions of the essential metals on SUA.ResultsIn the multivariable linear regression, the association of blood Mg, Mn, and Cu with SUA was statistically significant, both in considering multiple metals and a single metal. In WQS regression [β=13.59 (95%CI: 5.57, 21.60)] and BKMR models, a positive association was found between the mixture of essential metals in blood and SUA. Specifically, blood Mg and Cu showed a positive association with SUA, while blood Mn showed a negative association. Additionally, no interactions between individual metals on SUA were observed.DiscussionIn conclusion, further attention should be paid to the relationship between the mixture of essential metals in blood and SUA. However, more studies are needed to confirm these findings.

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“…Consistent with previous similar studies [ 25 , 29 , 30 ], demographic data collection involved categorizing participants into specific age groups: children and adolescents (6–18 years), adults (19–59 years), and the elderly (≥60 years) [ 31 ]. Sex was recorded as male or female; race was categorized as non-Hispanic White, non–Hispanic Black, Mexican American, other Hispanic, and other races; and family income and poverty ratio (PIR) were categorized as <1.30, 1.30–3.50, and >3.50 [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

Chen,

Gu,

Zhou

et al. 2024

Metabolites

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Herein, we explored the overall association between metal mixtures and lung functions in populations of varying ages and the relationship among the associated components. The 2007–2012 National Health and Nutrition Examination Survey data of 4382 American participants was analyzed, and generalized linear, elastic net, quantile g–computation, and Bayesian kernel machine regression models were used to evaluate the relationship between exposure to the metal mixture and lung function at various ages. The results of barium exposure at distinct stages revealed that children and adolescents exhibited greater lung function changes than those in adults and the elderly. Additionally, compared with children and adolescents, cadmium– and arsenic–containing metabolites contributed to nonconductive lung function changes in adults and the elderly exposed to metal mixtures. The results showed that the effects of exposure to metal mixtures on lung function in children and adolescents were predominantly caused by lead and barium. Altogether, children and adolescents were found to be more susceptible to metal–exposure–mediated lung function changes than adults and the elderly.

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Associations of perchlorate, nitrate, and thiocyanate with metabolic syndrome and its components among US adults: A cross-sectional study from NHANES

Cited by 10 publications

References 62 publications

Sex Specificity in the Mixed Effects of Blood Heavy Metals and Cognitive Function on Elderly: Evidence from NHANES

Sex Specificity in the Mixed Effects of Blood Heavy Metals and Cognitive Function on Elderly: Evidence from NHANES

Associations between blood essential metal mixture and serum uric acid: a cross-sectional study

The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

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