Associations between blood essential metal mixture and serum uric acid: a cross-sectional study

Wang, Dongmei; Li, Yue; Duan, Hualin; Zhang, Shuting; Liu, Lingling; He, Yajun; Chen, Xingying; Jiang, Yuqi; Ma, Qintao; Yu, Genfeng; Liu, Siyang; Yao, Nanfang; Liang, Yongqian; Lin, Xu; Liu, Lan; Wan, Heng; Shen, Jie

doi:10.3389/fpubh.2023.1182127

Cited by 3 publications

(1 citation statement)

References 70 publications

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“…The balance of essential elements was crucial to endocrine function [ 6 ]. Our previous studies found that blood magnesium (Mg) was positively associated with serum uric acid, dyslipidemia, and thyroid nodules [ 7 – 9 ]. What’s more, growing evidence has suggested that the imbalance of essential elements seems to be related to the onset and progression of diabetes [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study

Wang,

Ye,

Liu

et al. 2024

Nutr Metab (Lond)

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Background Although several studies have found the relationship between essential elements and diabetes, the studies about the association of essential elements with diabetes diagnosed according to an oral glucose tolerance test (OGTT) and glycated hemoglobin (HbA1c) in a sex- and age-specific manner were limited. To investigate the linear and nonlinear relationship of five essential elements including iron (Fe), copper (Cu), Zinc (Zn), magnesium (Mg), and calcium (Ca) with diabetes, fasting plasma glucose (FPG), 2-h postprandial plasma glucose (PPG), and HbA1c and to evaluate the sex- and age-specific heterogeneities in these relationships. Methods A total of 8392 community-dwelling adults were recruited to complete a questionnaire and undergo checkups of anthropometric parameters and serum levels of five metals (Fe, Cu, Zn, Mg, and Ca). The multivariable logistic and linear regression, the restricted cubic spline (RCS) analysis, and subgroup analysis were applied to find the associations between the essential elements and the prevalence of diabetes as well as FPG, PPG, and HbA1c. Results In the multivariable logistic regression and multivariable linear regression, serum Cu was positively associated with FPG, PPG, and HbA1c while serum Mg was significantly inversely correlated with FPG, PPG, HbA1c, and diabetes (all P < 0.001). In the RCS analysis, the non-linear relationship of Cu and diabetes (P < 0.001) was found. In the subgroup analysis, stronger positive associations of Cu with diabetes (P for interaction = 0.027) and PPG (P for interaction = 0.002) were found in younger women. Conclusions These findings may lead to more appropriate approaches to essential elements supplementation in people with diabetes of different ages and sexes. However, more prospective cohort and experimental studies are needed to probe the possible mechanism of sex- and age-specific associations between serum essential elements and diabetes.

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Section: Introductionmentioning

confidence: 99%

Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study

Wang,

Ye,

Liu

et al. 2024

Nutr Metab (Lond)

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Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout

Skalny,

Korobeinikova,

Sotnikova

et al. 2024

Biol Trace Elem Res

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Uric acid mediates the relationship between mixed heavy metal exposure and renal function in older adult people

Pan,

Niu,

Duan

et al. 2024

Front. Public Health

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BackgroundPopulation aging is a pivotal trend observed globally, and the exposure to heavy metals can exacerbate the aging process and lead to kidney damage. However, the impact of combined heavy metal exposure on renal function among older individuals remains elusive. Our study employs machine learning techniques to delve into the effects and underlying mechanisms of mixed exposure to heavy metals on the renal function of the aging population.MethodsThis study extracted comprehensive data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015 and 2020. A total of 3,175 participants aged 60 years and above, with complete information on six metals – lead, cadmium, manganese, cobalt, mercury, and selenium, along with relevant covariates, were included in the study. To assess the impact of single or mixed metal exposure on the renal function of older adult individuals, various statistical techniques were employed: multiple logistic regression, weighted quantitative sum (WQS) regression, Bayesian kernel machine regression (BKMR), and mediation effects analysis.ResultsMultiple logistic regression revealed that selenium and manganese were protective factors for chronic kidney disease (CKD). Cobalt was a risk factor for CKD. High concentrations of lead, cadmium, and cobalt were risk factors for urinary albumin creatinine ratio (ACR). WQS analyses revealed that mixed metal exposure was positively correlated with estimated glomerular filtration rate (eGFR) but negatively correlated with CKD. Selenium and manganese can neutralize the effects of other metals on eGFR. Mixed metal exposure was positively correlated with ACR, with lead and cadmium having a substantial effect. Mediation analysis showed that uric acid (UA) had a mediating effect of 9.7% and −19.7% in the association between mixed metals exposure and proteinuria and CKD, respectively.ConclusionThe impact of heavy metals on renal function in the older adult differs from that of adolescents and adults. This study suggests that elevated levels of mixed metals exposure are linked to proteinuria and CKD, with UA serving as a mediating factor.

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Associations between blood essential metal mixture and serum uric acid: a cross-sectional study

Cited by 3 publications

References 70 publications

Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study

Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study

Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout

Uric acid mediates the relationship between mixed heavy metal exposure and renal function in older adult people

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