Associations of olfactory dysfunction with anthropometric and cardiometabolic measures: Findings from the 2013–2014 national health and nutrition examination survey (NHANES)

Gallo, Samantha; Byham‐Gray, Laura; Duffy, Valerie B.; Hoffman, Howard J.; Hayes, John E.; Rawal, Shristi

doi:10.1016/j.physbeh.2019.112702

Cited by 31 publications

(46 citation statements)

References 44 publications

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“…These inconsistent results may be a result of the varying age distributions, as well as different race, assessment methods, definitions for olfactory dysfunction, and included variables. More importantly, although considered one of the most important risk factors for olfactory dysfunction, these prior studies did not include sino-nasal disease as a variable during analysis 8,12,13 . In this study, a history of rhinosinusitis was considered the most important risk factor for olfactory dysfunction among the analysed variables.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In addition to considering the association between obesity and olfactory dysfunction, some studies have investigated the relationship between abdominal obesity and olfactory dysfunction in specific 13,35 . A recent American study reported a significant association between higher waist circumference and olfactory dysfunction in middle-aged women 13 . A German study reported that abdominal obesity was inversely associated with grey matter volume, including the olfactory sulcus, although differences were not analysed according to stratification by sex 35 .…”

Section: Discussionmentioning

confidence: 99%

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The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

Roh

Lee

Kim

et al. 2021

Sci Rep

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While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and the sex-associated differences within the general population. We examined 20,016 adults aged 40 and older from the Korean National Health and Nutrition Examination Survey. All subjects reported on their history of OD. CVD and its risk factors included coronary artery disease (CAD), stroke, hypertension, diabetes, obesity, abdominal obesity, and hypertriglyceridemia; logistic regression was used to analyse their associations with OD, and additive interaction was used to analyse the interaction between risk factors and sex. In males, CAD was more likely to be associated with OD (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.05–3.14), whereas abdominal obesity was associated with OD in females (OR 1.39, 95% CI 1.06–1.84).Additive interaction were observed between abdominal obesity and female sex with a relative excess risk of interaction of 0.45 (95% CI 0.26–0.63). Our findings suggest the relationship between OD and CVD and its risk factors and sex-associated differences among middle-aged and older adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

Roh

Lee

Kim

et al. 2021

Sci Rep

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“…These data sources have the potential to further inform us about the natural history of taste and smell dysfunction and factors associated with recovery. In the United States, the National Health and Nutrition Examination Survey (NHANES) now incorporates questions related to smell and taste alterations, offering yet another resource for querying population data ( Rawal et al 2015 ; Hoffman et al 2016 ; Gallo et al 2020 ). When deciding among the available tests to use in large surveys, consider using a test with high reliability coefficients and, when possible, a test that has previously been used in other large surveys to aid in comparison across studies.…”

Section: Suggestions For High-yield Next Stepsmentioning

confidence: 99%

Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities

et al. 2020

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The chemical senses of taste and smell play a vital role in conveying information about ourselves and our environment. Tastes and smells can warn against danger and also contribute to the daily enjoyment of food, friends and family, and our surroundings. Over 12% of the US population is estimated to experience taste and smell (chemosensory) dysfunction. Yet, despite this high prevalence, long-term, effective treatments for these disorders have been largely elusive. Clinical successes in other sensory systems, including hearing and vision, have led to new hope for developments in the treatment of chemosensory disorders. To accelerate cures, we convened the “Identifying Treatments for Taste and Smell Disorders” conference, bringing together basic and translational sensory scientists, health care professionals, and patients to identify gaps in our current understanding of chemosensory dysfunction and next steps in a broad-based research strategy. Their suggestions for high-yield next steps were focused in 3 areas: increasing awareness and research capacity (e.g., patient advocacy), developing and enhancing clinical measures of taste and smell, and supporting new avenues of research into cellular and therapeutic approaches (e.g., developing human chemosensory cell lines, stem cells, and gene therapy approaches). These long-term strategies led to specific suggestions for immediate research priorities that focus on expanding our understanding of specific responses of chemosensory cells and developing valuable assays to identify and document cell development, regeneration, and function. Addressing these high-priority areas should accelerate the development of novel and effective treatments for taste and smell disorders.

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“…In contrast, dysfunction was associated with higher BMI in middle‐aged women. With regard to blood pressure, no significant associations were observed in the NHANES study . In a study by Lee et al, wherein the olfactory calcium‐sensing receptor was activated the researchers found that arterial blood pressure was elevated in a rat model by affecting sympathetic control through olfactory G‐protein‐coupled receptors.…”

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confidence: 94%

Recent advances in blood pressure research

Mrowka

2019

Acta Physiologica

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Associations of olfactory dysfunction with anthropometric and cardiometabolic measures: Findings from the 2013–2014 national health and nutrition examination survey (NHANES)

Cited by 31 publications

References 44 publications

The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities

Recent advances in blood pressure research

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