Associations of neuralgic amyotrophy with <scp>COVID</scp>‐19 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database

Kim, Jee‐Eun; Park, Jin; Min, Young Gi; Hong, Yoon‐Ho; Song, Tae‐Jin

doi:10.1002/mus.27734

Cited by 7 publications

(5 citation statements)

References 23 publications

(50 reference statements)

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“… 77 In view of the above findings, it can be theorized that mRNA vaccines are more likely to be associated with the subsequent development of PTS, and this hypothesis has been previously been tested and confirmed by Kim et al . 75 This finding is especially important in the context of the COVID-19 pandemic, during which clinicians should have a high index of suspicion of PTS in patients who present with compatible symptoms who have received Comirnaty in the recent past. It is noteworthy that, in the present review, we found that most (78.3%) patients experienced symptoms of PTS ipsilateral to the injection site, which suggests that the pathogenesis may involve the local spread of the inoculum.…”

Section: Discussionmentioning

confidence: 99%

“…PTS has also been shown to be associated with immunization, with clinical evidence suggesting that vaccinations against influenza, 71 typhoid, 72 human papillomavirus, 73 and DPT 74 in children are possible etiologic factors. Because cases of PTS have been increasingly reported following COVID-19 vaccination, Kim et al 75 performed a study using disproportionality analysis, and concluded that the risk of neuralgic amyotrophy associated 76 During the COVID-19 pandemic, cases of PTS were reported after both vaccination and infection. In this review, we have summarized the findings associated with 32 cases that developed following vaccination and 36 that developed following infection.…”

Section: Discussionmentioning

confidence: 99%

“…Because cases of PTS have been increasingly reported following COVID-19 vaccination, Kim et al . 75 performed a study using disproportionality analysis, and concluded that the risk of neuralgic amyotrophy associated with COVID-19 vaccines does not exceed that associated with influenza vaccines. However, this weak association is still crucial in the context of both vaccination hesitancy among the general population and other COVID-19 vaccination-related neuropathic symptoms and syndromes.…”

Section: Discussionmentioning

confidence: 99%

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Association of Parsonage–Turner syndrome with COVID-19 infection and vaccination: a systematic review

Ameer,

Haiy,

Bajwa

et al. 2023

J Int Med Res

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Objectives The exact etiology of Parsonage–Turner syndrome is unknown, but it is known to be preceded by infection, vaccination, or surgical intervention. In this review, we describe associations of Parsonage–Turner syndrome with COVID-19 infection and vaccination. Methods A systematic literature search was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar. Microsoft Excel was used for data extraction and statistical analysis. The quality of case reports and case series was assessed using the Joanna Briggs Institute Critical Appraisal Tool. Results We selected 44 case reports and 10 case series, including 68 patients (32 post-vaccination and 36 with post-COVID-19 infection Parsonage–Turner syndrome). Middle-aged males were predominantly affected in both groups. The most frequently administered vaccine was Comirnaty (Pfizer) (53%). The mean latency was 11.7 days in the post-vaccination group and 20.3 days in the post-infection group. The most affected nerves in both groups were the axillary, suprascapular, and musculocutaneous nerves; and 78.1% and 38.9% of patients showed partial amelioration of their symptoms in the post-vaccination and post-infection groups, respectively. Conclusion Post-vaccination Parsonage–Turner syndrome presents earlier than post-infection disease. Pain and sensorimotor deficits of the upper limb are common in both situations. Complete or partial recovery occurs in most cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of Parsonage–Turner syndrome with COVID-19 infection and vaccination: a systematic review

Ameer,

Haiy,

Bajwa

et al. 2023

J Int Med Res

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“…Another limitation of the present work is that we could not analyze the epidemiology of PTS following SARS-CoV-2 vaccination. However, previous research aimed to investigate the link between neuralgic amyotrophy and COVID-19 vaccination using the World Health Organization’s global pharmacovigilance database (VigiBase) [ 84 ]. Of 1,731,147 adverse drug reactions (ADR) reports related to COVID-19 vaccines, the authors identified 335 (0.02%) neuralgic amyotrophy cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, the level of disproportionality observed was not greater than that seen with influenza vaccines. The association between PTS and mRNA-based COVID-19 vaccinations was stronger compared to the ChAdOx1 nCoV-19 vaccine [ 84 ]. Nonetheless, ADRs in countries where reports are not linked to VigiBase might have been omitted.…”

Section: Discussionmentioning

confidence: 99%

Parsonage–Turner Syndrome following COVID-19 Vaccination: A Systematic Review

Rosca,

Al-Qiami,

Cornea

et al. 2024

Vaccines

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Background: Parsonage–Turner syndrome (PTS) is an inflammatory condition of the brachial plexus, with more than half of patients presenting a trigger, such as infection or vaccination. Our objective was to synthesize the clinical and paraclinical features, therapeutic responses, and outcomes of PTS post-COVID-19 vaccination. Methods: We systematically reviewed two databases (LitCOVID and the WHO database on COVID-19) up to January 2024 following a published protocol (OSF registries). Results: We included 59 cases. PTS occurred more frequently in males (61.1% mRNA group, 83.3% viral vector group). Patients in the mRNA group were younger (41.7% between 41 and 50 years vs. 38.9% between 61 and 70 years). Most cases had sudden pain within two weeks. Unilateral PTS was present in 94.4% of mRNA and all viral vector-vaccinated cases. Symptoms included pain (97.1% and 92.3%, respectively), usually followed within two weeks by motor deficits (97.2% and 94.1%, respectively), amyotrophy (30% and 81.8%, respectively), paresthesia (50% and 27.3%, respectively), and sensory loss (33.3% and 38.5%, respectively). Viral vector vaccine recipients had nerve involvement outside the brachial plexus. Ancillary investigations revealed CSF albuminocytological dissociation (33.3% and 100%, respectively) and ipsilateral axillary lymphadenopathy. Two PTS cases worsened after the second mRNA dose, and another recurred after influenza vaccination. One patient well tolerated the second dose of the viral vector vaccine, but symptoms reemerged in another. Conclusions: Current evidence suggests PTS may occur after all COVID-19 vaccine types, with some subgroup differences. Also, PTS might recur with subsequent similar or unrelated vaccines.

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Associations of neuralgic amyotrophy with COVID‐19 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database

et al. 2022

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Associations of neuralgic amyotrophy with COVID‐19 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database

Abstract: Longitudinal evaluation of SMN levels as biomarker for spinal muscular atrophy: results of a phase IIb double-blind study of salbutamol.

Cited by 7 publications

References 23 publications

Association of Parsonage–Turner syndrome with COVID-19 infection and vaccination: a systematic review

Association of Parsonage–Turner syndrome with COVID-19 infection and vaccination: a systematic review

Parsonage–Turner Syndrome following COVID-19 Vaccination: A Systematic Review

Associations of neuralgic amyotrophy with COVID‐19 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database

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