Associations of multiple metals with lung function in welders by four statistical models

Wu, Luli; Cui, Fengtao; Ma, Junxiang; Huang, Zhengjie; Zhang, Shixuan; Xiao, Zhen; Li, Jie; Ding, Xinping; Niu, Piye

doi:10.1016/j.chemosphere.2022.134202

Cited by 28 publications

(10 citation statements)

References 33 publications

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“…conducted a study on the association between metals co-exposure and lung function in welders, and the results showed that the joint exposure of heavy metals was related to the decline of lung function of workers (Wu et al 2022), which was consistent with our results.…”

Section: Discussionsupporting

confidence: 90%

“…2015;. This is a novel semi-parametric modeling method that can exibly capture the combined effects of mixture components, allowing for potential interactions and nonlinear effects(Wu et al 2022). BKMR model was performed using the BKMR program package…”

mentioning

confidence: 99%

“…Moreover, FEV1 and FEV1/FVC can represent the small airway limitation; peak expiratory ow (PEF) can only re ect central airway obstruction. Sometimes when PEF is normal, FEV1 has decreased(Luo et al 2021;Wu et al 2022).…”

mentioning

confidence: 99%

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Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Zheng

Tian

et al. 2022

Preprint

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Background Heavy metal exposure is associated with decreased lung function, but the relationship between metals co-exposure and lung function in rural areas of northwest China remains unclear. Therefore, the purpose of this study is to explore the effects of single or co-exposure of heavy metals on lung function in a rural cohort of northwest China. Methods All participants were recruited from the Dongdagou-Xinglong (DDG-XL) rural cohort of Gansu province. Urine levels of 10 common heavy metals were detected, including cobalt (Co), nickel (Ni), molybdenum (Mo), cadmium (Cd), stibium (Sb), copper (Cu), zinc (Zn), mercury (Hg), lead (Pb) and manganese (Mn). The lung function was detected by measuring percentages of predicted forced vital capacity (FVC%) and forced expiratory volume in one second (FEV1%) as well as the ratio of FEV1/FVC. We also analyzed the association between heavy metals and pulmonary ventilation dysfunction (PVD). Restricted cubic spline, logistic regression, linear regression and bayesian kernel machine regression (BKMR) were used to analyze the relationship between heavy metals exposure and lung function. Results Finally, a total of 382 participants were included in this study with the average age of 56.69 ± 7.32 years, 82.46% of them used solid fuels for heating and cooking. Logistic regression analysis showed that higher concentration of Hg, Mn, Sb and lower Mo may be risk factors for PVD. And linear regression showed that FEV1% and FVC% were negatively correlated with Sb, Hg, Mn, but positively correlated with Mo. Through BKMR model, we found the lung function decreased with the increase of heavy metals concentration. In addition, Hg and Mn made an enormous contribution to the decline of lung function. Simultaneously, subgroup analyses showed that the males, the people with BMI ≥ 24kg/m2 and used solid fuels showed a higher risk of PVD when exposed to Co, Zn and Hg. Conclusions This study found that heavy metals exposure were associated with impairment of lung function regardless of single exposure or co-exposure, particularly for Hg and Mn.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

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Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Zheng

Tian

et al. 2022

Preprint

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“…Consistent with our results in the welder’s pneumoconiosis group, a study in a cadmium battery plant showed that high Cd concentration was associated with decreased values for FEV1, PEF, MEF25, MEF50, and MEF75, suggesting a mild airway obstruction [ 48 ]. Another cross-sectional study on welders’ lung function found that urinary Cd was negatively associated with FVC and FEV1 [ 49 ]. Exposure to other metals could also pose a threat to the respiratory system.…”

Section: Discussionmentioning

confidence: 99%

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Zhou

Wang

Chen

et al. 2022

IJERPH

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Long-term inhalation of welding fume at high exposure can cause welder’s pneumoconiosis, and metals in welding dust are associated with respiratory dysfunction. This cross-sectional study, which contains 384 Chinese male workers who were or had been working in a container factory, aimed to assess the potential risk of haemal and urinary metal content in welder’s pneumoconiosis. Further, we investigated their effects on lung function parameters. Metal content and lung function were measured using inductively coupled plasma–mass spectrometry (ICP-MS) and spirometer, respectively. The concentration and metal content of respirable dust as well as total dust were collected at this container factory. Lung function of cases with welder’s pneumoconiosis was significantly worse, as indicated by lower values of FVC, FVC% predicted, FEV1, FEV1% predicted, MEF25% predicted, and MMEF% predicted (p < 0.05). Results of logistic regression models showed that haemal Cr and Zn were risk factors of welder’s pneumoconiosis (OR = 4.98, 95%CI: 1.73–21.20, p = 0.009 for Cr; OR = 5.23, 95%CI: 1.56–41.08, p = 0.033 for Zn) after adjusted with age, BMI, working years, welding dust exposure years, and smoking status. Multiple linear regression models showed that several metals (haemal Cd and Pb; urinary Cd and Fe) were significantly associated with different lung function indices in the welder’s pneumoconiosis group. Compared to non-welders, welders were exposed to considerably higher levels of respirable dust, total dust, and six kinds of metals (p < 0.05). In conclusion, haemal Cr and Zn are positively related to welder’s pneumoconiosis. Meanwhile, Cd and Pb might worsen lung function in welder’s pneumoconiosis.

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“…We extended the concept of BKMR modeling, previously used to assess exposures to groups of chemicals/physical hazards [ [11] , [12] , [13] , [14] , 16 ], to investigate how a “mixture” of factors (effort, reward, and overcommitment) are related to poorer mental health, denoted as h(·) , while adjusting for confounders,. We also investigated any potential non-linear, interactive effects these factors have on mental health.…”

Section: Methodsmentioning

confidence: 99%

Associations between Poorer Mental Health with Work-Related Effort, Reward, and Overcommitment among a Sample of Formal US Solid Waste Workers during the COVID-19 Pandemic

Shkembi

Levy

Neitzel

2023

Safety and Health at Work

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Associations of multiple metals with lung function in welders by four statistical models

Cited by 28 publications

References 33 publications

Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Association of multi-heavy metals exposure and lung function in a typical rural cohort of Northwest China

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Associations between Poorer Mental Health with Work-Related Effort, Reward, and Overcommitment among a Sample of Formal US Solid Waste Workers during the COVID-19 Pandemic

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