Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians

Fu, Shihui; Yao, Yao; Lv, Faqin; Fu, Zhang; Zhao, Yali; Luan, Fuxin

doi:10.1186/s12967-018-1691-4

Cited by 18 publications

(22 citation statements)

References 43 publications

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“…However, as for C3, its effect on PADLs can be considered as two-fold. As an immune-inflammatory mediator, it plays a similar role to C4 and we have confirmed the significant association between complement system and metabolic syndrome in Chinese community-dwelling centenarians in our previous study ( 6 ). In contrast, C3 also plays a key role in promoting skeletal muscle regeneration in the process of aging and injury according to previous experimental studies.…”

Section: Discussionsupporting

confidence: 89%

“…Ethnicity was categorized as either “Han” (the predominant ethnicity in China) or “non-Han”; education level was categorized as “illiteracy” or not due to the generally poor level of education among centenarians in Hainan; the season of blood collection was dichotomized into summer (April–September) and winter (October–March). Hypertension, diabetes, and dyslipidemia were diagnosed according to the corresponding biochemical indicators ( 6 ); depressive symptoms were measured by the shortened version of the Geriatric Depression Scale (GDS-15) ( 41 ). Current health status and medical history, including visual impairment and auditory impairment, were recorded as self-reported combined with the medical records of the participants.…”

Section: Methodsmentioning

confidence: 99%

“…Complement components 3 (C3) and 4 (C4) are widely involved in three activating pathways of complements (classical pathway, alternative pathway, and mannose-binding lectin pathway) and they play vital roles in anti-infection and inflammatory response, as well as in metabolism and circulation regulation (2)(3)(4). Existing studies have shown that elevated levels of C3 and C4 were associated with higher prevalence or incidence of metabolic syndrome and cardiovascular diseases (4)(5)(6)(7)(8)(9). In addition, the biological activity of the complement system is widely involved in muscle regulation (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Zhang

Zhao

et al. 2020

Front. Immunol.

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Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function. It is hypothesized that serum complement components may interact with vitamin D in respect of the physical activities of daily living (PADLs). Objective: To investigate if serum complement components 3 (C3), complement components 4 (C4), and 25-hydroxyvitamin D [25(OH)D] associate with PADLs, and to examine whether the association between 25(OH)D levels and PADLs varies at different complement component levels among Chinese centenarians. Methods: This study was conducted in a group of population-based centenarians. PADLs were evaluated using the Barthel Index. Multiple regressions were used to analyze the associations among 25(OH)D, complements C3 and C4, and PADLs. Results: Among 943 participants, 672 (71.3%) had physical dependence (PD). After adjusting for potential confounders, serum 25(OH)D and C3 levels were positively correlated with PADLs, while C4 levels were negatively correlated with PADLs (Ps < 0.05). Serum 25(OH)D levels significantly interacted with both C3 (P for interaction = 0.033) and C4 (P for interaction = 0.006) levels on PADLs. At lower complement component levels, the multivariate odds ratios (ORs) of the upper tertile of vitamin D for PD were 0.32 (95% CI: 0.18-0.55) in the C3 group and 0.29 (95% CI: 0.16-0.50) in the C4 group. At higher complement component levels, the ORs in the C3 and C4 groups were not statistically significant. Zhang et al. Complement Component, 25(OH)D and PADLs Conclusions: In a group of population-based Chinese centenarians, we observed that serum complement C3 and 25(OH)D levels were positively associated with PADLs, while C4 was negatively associated with PADLs. The associations between 25(OH)D levels and PADLs were more pronounced in groups with lower serum complement component levels.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Zhang

Zhao

et al. 2020

Front. Immunol.

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“…All research team members were well trained according to a unified standard. Based on recommendations from the World Health Organization, weight was measured twice on a digital scale while participants wore light clothing without shoes, height was measured twice using a wall-mounted tape with participants standing without shoes, and waist circumference (WC) was measured twice using a soft tape at the midpoint between the last rib and the iliac crest [ 14 ]. Based on Chinese guidelines on the prevention and control of obesity, the presence of abdominal obesity was established when WCs were ≥ 85 cm for males and ≥ 80 cm for females [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Ping

et al. 2021

J Transl Med

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Objective The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals for thousands of years. For the first time, the current study was designed to investigate the relationships between sex hormones, bone turnover, abdominal obesity, nutritional status and centenarian longevity in the oldest females. Methods The China Hainan Centenarian Cohort Study was performed in 18 cities and counties of Hainan Province using standard methodology in 500 centenarian females and 237 oldest females aged between 80 and 99 years. Results Centenarians were inversely associated with the geriatric nutritional risk index [Exp(B) (95% CI): 0.901 (0.883–0.919)] and abdominal obesity [Exp(B) (95% CI): 0.719 (0.520–0.996)] and positively associated with prolactin [Exp(B) (95% CI): 1.073 (1.044–1.103)], progesterone [Exp(B) (95% CI): 44.182 (22.036–88.584)], estradiol [Exp(B) (95% CI): 1.094 (1.071–1.119)], osteocalcin [Exp(B) (95% CI): 1.041 (1.028–1.054)], β-crossLaps [Exp(B) (95% CI): 63.141 (24.482–162.848)] and parathyroid [Exp(B) (95% CI): 1.022 (1.013–1.031)] hormone levels (P < 0.05 for all). The geriatric nutritional risk index and abdominal obesity were inversely associated with luteinizing hormone [β coefficient (95% CI): − 0.001 (− 0.002 to 0.001)]; Exp(B) (95% CI): 0.985 (0.974–0.996)], follicle-stimulating hormone [β coefficient (95% CI): 0.000 (− 0.001 to 0.000)]; Exp(B) (95% CI): 0.990 (0.985–0.996)], osteocalcin [β coefficient (95% CI): − 0.001 (− 0.001 to 0.000)]; Exp(B) (95% CI): 0.987(0.977–0.997)] and β-crossLaps [β coefficient (95% CI): − 0.100 (− 0.130 to 0.071)]; Exp(B) (95% CI): 0.338 (0.166–0.689)] levels (P < 0.05 for all). Conclusions Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover. Nutritional status and abdominal obesity had inverse relationships with sex hormones and bone turnover. Increased sex hormones and bone turnover may be representative of centenarian longevity. Optimizing nutritional status and avoiding abdominal obesity may increase sex hormones and bone turnover and promote centenarian longevity and successful aging.

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“…The China Hainan Centenarian Cohort Study provides a considerable population-based sample of centenarian adults. 20 This study aimed to explore the associations of ARHL with ARCD and depression in Chinese centenarians and oldest-old adults.…”

Section: Introductionmentioning

confidence: 99%

Associations between age-related hearing loss, cognitive decline, and depression in Chinese centenarians and oldest-old adults

Feng

Lin

et al. 2022

Therapeutic Advances in Chronic Disease

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Objective: Age-related hearing loss (ARHL) and age-related cognitive decline (ARCD) are leading causes of disability in older adults. ARHL may increase ARCD risk and cause depression development. This study aimed to explore the associations of ARHL with ARCD and depression in Chinese centenarians and oldest-old adults. Methods: A household survey was conducted on 859 centenarians and oldest-old adults residing in 16 cities and counties in China. Basic information was collected using interview questionnaires, physical examinations, and blood tests conducted by systematically trained local doctors and nurses. Results: In total, 501 (58.3%), 649 (75.6%), and 211 (24.6%) participants had ARHL, ARCD, and depression, respectively. The prevalence of ARCD and depression was significantly higher in participants with ARHL than in those without ARHL (all p < 0.05). Participants with ARHL had significantly lower Mini-Mental State Examination (MMSE) scores indicative of more cognitive decline, and significantly higher 15-item version of the Geriatric Depression Scale (GDS-15) scores suggesting greater levels of depression, than those without ARHL (all p < 0.05). Multivariate logistic regression analyses (Stepwise) indicated that ARHL was significantly and positively associated with ARCD [odds ratio (OR): 1.594, 95% confidence interval (CI): 1.132, 2.245] and depression (OR: 1.623, 95% CI: 1.139, 2.314; all p < 0.05). Multivariate linear regression analyses (Stepwise) indicated that ARHL was significantly and inversely associated with MMSE scores ( B: −2.520, 95% CI: −3.356, −1.684) and significantly and positively associated with GDS-15 scores ( B: 0.713, 95% CI: 0.328, 1.098; all p < 0.05). Conclusion: ARHL is independently associated with ARCD and depression in Chinese centenarians and oldest-old adults.

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Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians

Cited by 18 publications

References 43 publications

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Associations between age-related hearing loss, cognitive decline, and depression in Chinese centenarians and oldest-old adults

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