Associations of heart failure with susceptibility and severe complications of COVID‐19: A nationwide cohort study

Abstract

Infection is associated with occurrence and worsening of heart failure (HF). However, studies on the association of susceptibility and severe complications of coronavirus disease 2019 (COVID-19) with HF history are limited. From the Korean nationwide COVID-19 data set, 212,678 participants with at least one severe acute respiratory syndrome coronavirus 2 real-time reverse transcription polymerase chain reaction (RT-PCR) test were included between January 1 and June 4, 2020. To investigate the association of HF with susceptibility and severe complications of COVID-19, 1:4 ratio propensity score matching (PSM) and logistic regression analysis were performed. The primary outcome was a composite outcome of mechanical ventilation, intensive care unit (ICU) admission, and death. After PSM, COVID-19 PCR positivity did not show a significant difference according to HF history in multivariable analysis (odds ratio [OR]: 0.91, 95% confidence interval (CI) (0.79-1.04), p = 0.146). Of 7630 individuals with confirmed COVID-19 infection, 310 (4.1%) had HF history. The overall primary outcome occurred in 426 (5.6%) individuals, including 159 (2.1%) cases of mechanical ventilation, 254 (3.3%) cases of ICU admission, and 215 (2.8%) cases of death. In multivariate logistic analysis, presence of HF history was associated independently with primary outcome (OR: 1.99, 95% CI: 1.42-2.79, p < 0.001), particularly mortality (OR: 2.02, 95% CI: 1.36-3.00, p < 0.001). Our study demonstrated that HF history is associated poor prognosis, particularly mortality, in COVID-19. Patients with HF can have severe complication if infected with COVID-19; therefore, careful management are necessary.

Association of Cerebral Venous Thrombosis with mRNA COVID-19 Vaccines: A Disproportionality Analysis of the World Health Organization Pharmacovigilance Database

“…Coronavirus disease 2019 (COVID-19) is spreading rapidly [ 1 , 2 , 3 , 4 , 5 ]. Herd immunity is important for the prevention and suppression of the spread of COVID-19, and vaccination is an essential requirement for herd immunity [ 6 ].…”

Association of atrial fibrillation with infectivity and severe complications of COVID‐19: A nationwide cohort study

“…Until recently, several studies have suggested factors, such as diabetes mellitus, heart failure, cancer, allergic diseases, and chronic kidney diseases that are associated with a poor prognosis after COVID‐19 infection. 2 , 3 , 4 …”

“…Until recently, several studies have suggested factors, such as diabetes mellitus, heart failure, cancer, allergic diseases, and chronic kidney diseases that are associated with a poor prognosis after COVID-19 infection. [2][3][4] Infection is associated with the occurrence, recurrence, and progression of atrial fibrillation (AF), and is also closely related to poor prognosis. 5,6 Recently, a relationship between COVID-19 infection and AF has been proposed, 7 with the likelihood of AF being increased in COVID-19 patients.…”

“…Therefore, it is essential to differentiate and treat patients likely to develop severe complications due to COVID‐19. Until recently, several studies have suggested factors, such as diabetes mellitus, heart failure, cancer, allergic diseases, and chronic kidney diseases that are associated with a poor prognosis after COVID‐19 infection 2–4 …”

Predicting Mortality in Intensive Care Unit Patients With Heart Failure Using an Interpretable Machine Learning Model: Retrospective Cohort Study

“…Each year, HF costs an estimated US $108 billion, constituting 2% of the health care budget globally, and it is predicted to continue to rise, yet half of it is possibly avoidable [ 3 ]. As COVID-19 continues to spread across the world, HF, a severe complication, is associated with poor outcome and death from COVID-19 [ 4 , 5 ].…”