Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity

Abstract

Background Cardiometabolic multimorbidity (CM) is an increasing public health and clinical concern. However, predictors for the development and prognosis of CM are poorly understood. The aims of this study were to investigate the relation between handgrip strength (HGS) and the risk of CM and to examine the association of HGS with all-cause mortality risk among patients with CM. Methods This prospective cohort study involved 493,774 participants from the UK Biobank. CM was defined as the simultaneous occurrence of two or more of the following conditions: type 2 diabetes, stroke, and coronary heart disease (CHD). Cox proportional hazards models were performed to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). Results During a median follow-up of 12.1 years, 4701 incident CM cases were documented among participants with none cardiometabolic disease at baseline. Compared with the fourth quartile (Q4), the multivariable adjusted HR (95% CI) value of Q1 of HGS for developing CM was 1.46 (1.34–1.60). In participants with one cardiometabolic disease at baseline, participants in Q1 of HGS also possessed higher risk of CM than those in Q4, with HRs (95% CIs) being 1.35 (1.23–1.49) in patients with type 2 diabetes, 1.23 (1.04–1.46) in patients with stroke, and 1.23 (1.11–1.36) in patients with CHD. For participants with CM at recruitment, HGS was also associated with the risk of all-cause mortality (Q1 vs. Q4 HR: 1.57, 95% CI: 1.36–1.80). Conclusions Our study provided novel evidence that HGS could be an independent predictor of morbidity and all-cause mortality of CM.

Facial cues to physical strength are not always associated with facial masculinity: Comparative study of Europeans and Southern Siberians

“…In growing number of studies in children, adults, and elderly, physical strength is considered as a marker of individual developmental processes and health status. It is commonly used to define human body functional capabilities, that is, cardiorespiratory and functional fitness, risks of disability, morbidity, and mortality (Lu et al, 2022; Wang et al, 2020). Physical strength is usually measured by handgrip strength (HGS).…”

Low handgrip strength with or without asymmetry is associated with elevated all‐cause mortality risk in older Chinese males

“…This finding is partly consistent with previously reported results. Specifically, previous studies have reported that low HGS is linked to an increased risk of all-cause mortality, 18,19,28,29 and the coexistence of low HGS and HGS asymmetry in older adults often indicates the presence of severe muscular dysfunction, rather than low HGS or HGS asymmetry seen individually, increasing the risk of adverse health outcomes in older adults. 7,11,30 But another study reported that females rather than males with HGS asymmetry had shorter time-to-death intervals.…”

Fuerza prensil y composición corporal en escolares colombianos. Estudio piloto

“…Nuestros resultados son consistentes con evidencias previas que identifican a la fuerza prensil como un indicador de la composición corporal, específicamente en las variables de masa musculoesquelética y proteínas 23, 24 . Aunque la fuerza prensil evalúa directamente la fuerza máxima de la mano, es un predictor adecuado de la fuerza muscular total en niños, adolescentes, adultos y personas mayores 25 . Particularmente, en población escolar, un estudio de cohorte desarrollado en Australia demostró que la fuerza muscular se encuentra asociada con mayor masa musculoesquelética, debido a mecanismos que involucran hormonas como la testosterona, estrógenos y el factor de crecimiento insulínico tipo 1 (Insulin-like growth factor I, IGF-1, por sus siglas en inglés) en la unión músculo hueso 26 .…”