Associations of Gut Microbiota and Fatty Metabolism With Immune Thrombocytopenia

Yu, Xinhua; Zheng, Qin; He, Yi; Yu, Dandan; Chang, Guolin; Chen, Cheng; Bi, Lei; Jia, Lixin; Zhao, Misheng; Lin, Xiangyang; Zhu, Li

doi:10.3389/fmed.2022.810612

Cited by 11 publications

(12 citation statements)

References 62 publications

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“…30 In patients with immune thrombocytopenia (ITP), when compared to healthy volunteers, genus-level trends showed an increase in Bacteroides, Phascolarctobacterium, and Lactobacillus while decreasing in Ruminococcaceae UCG002, Eubacterium coprostanoligeues, Megamonas, and Lachnospiraceae NC2004. 31 This is consistent with our findings, indicating that Ruminococcus may play this role.…”

Section: Discussionsupporting

confidence: 93%

“…The 16S rRNA gene sequencing of fecal samples from AS patients and healthy controls revealed that the relative abundance of Bacteroides was increased in the AS group while the relative abundance of Ruminococcus , Helicobacter , and Parasutterella genus was decreased 30 . In patients with immune thrombocytopenia (ITP), when compared to healthy volunteers, genus‐level trends showed an increase in Bacteroides, Phascolarctobacterium, and Lactobacillus while decreasing in Ruminococcaceae UCG002, Eubacterium coprostanoligeues , Megamonas , and Lachnospiraceae NC2004 31 . This is consistent with our findings, indicating that Ruminococcus may play this role.…”

Section: Discussionmentioning

confidence: 99%

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The causality between gut microbiota and ankylosing spondylitis: Insights from a bidirectional two‐sample Mendelian randomization analysis

Wang,

Li,

Jin

et al. 2023

Int J of Rheum Dis

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BackgroundThe association between gut microbiota and ankylosing spondylitis (AS) has been reported in the literature; however, whether the two are correlative is unclear.MethodsSingle nucleotide polymorphisms associated with the gut microbiome composition and AS (968 AS cases and 336 191 controls) were obtained from published genome‐wide association studies in this two‐sample Mendelian randomization (MR) study. The causal relationship between gut microbiota and AS was estimated using the inverse‐variance weighted method, and the robustness of our findings was confirmed through a comprehensive series of sensitivity analyses.ResultsAnaerotruncus (OR = 0.9984, 95% CI, 0.9968–0.9999, p = .0405) and Ruminococcaceae UCG002 (OR = 0.9989, 95% CI, 0.9979–0.9999, p = .0375) were protective against AS. Defluviitaleaceae (OR = 1.0015, 95% CI, 1.0005–1.0025, p = .0048), Butyricicoccus (OR = 1.0016, 95% CI, 1.0001–1.0032, p = .0429), Coprococcus 3 (OR = 1.0016, 95% CI, 1.0000–1.0032, p = .0463), and Defluviitaleaceae UCG011 (OR = 1.0016, 95% CI, 1.0005–1.0027, p = .0041) exhibited significant positive correlations with heightened susceptibility to AS. Reverse MR revealed that AS does not affect the gut microbial composition.ConclusionOur study has established a genetically‐based causal relationship between gut microbiota and AS. This finding suggests that we may be able to target and regulate specific bacterial groups in the gut to prevent and treat AS.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The causality between gut microbiota and ankylosing spondylitis: Insights from a bidirectional two‐sample Mendelian randomization analysis

Wang,

Li,

Jin

et al. 2023

Int J of Rheum Dis

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“…In the immunosuppression model group, its elevated abundance may be more associated with the positive aspects. The decrease in its relative abundance correlates with the activation of abnormal immune responses, such as in the intestine of patients with Crohn’s disease ( Maldonado-Contreras et al, 2020 ), immune thrombocytopenia ( Yu et al, 2022 ), or IgA nephropathy ( Dong et al, 2020 ), where its abundance is significantly reduced. It suggests that the relative abundance of Megamonas is related to the immune status of the organism.…”

Section: Discussionmentioning

confidence: 99%

Effect of Echinacea on gut microbiota of immunosuppressed ducks

Lin

Zhi

et al. 2023

Front. Microbiol.

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IntroductionImmunosuppression puts animals in a susceptible state and disrupts the balance of intestinal flora, which can increase the risk of disease and cause serious harm to the farm. Echinacea can exert its immunomodulatory effect in various ways, but its influence on intestinal flora is unclear.MethodsTherefore, we investigated the effect of Echinacea extract (EE) on gut microbiota in immunosuppressed ducks by 16s-RNA sequencing in this experiment.ResultsThe results showed that EE significantly improved the weight gain of immunosuppressed ducks (p<0.001). It also increased the immune organ index (p<0.01) and upregulated the levels of TNF-α and IFN-γ (p<0.05) as well as IL-2 in the serum. The lesions of the bursa were evident compared to the spleen and thymus. After treatment in the EE group, the lymphocyte count of the bursa returned to healthy levels and the lesions were significantly improved. The diversity analysis showed that neither of the alpha-diversity indices showed a significant difference (p>0.05). However, the EE group had a trend closer to the healthy group compared to the M group. β-diversity analysis revealed a high degree of sample separation between the healthy and immunosuppressed groups. The sequencing result showed a significantly higher relative abundance of Prevotella and Prevotella_UCG_001 in the dexamethasone-treated group, which could be potential biomarkers of dexamethasone-induced immunosuppression. EE increased the relative abundance of Akkermansia, Bacteroides, and Alistipes and significantly decreased the relative abundance of Megamonas, Streptococcus, and Enterococcus (p<0.05).ConclusionThe results showed that Echinacea extract improves the development of immunosuppressed ducks and modulates intestinal immune function by increasing the abundance of beneficial bacterial genera in the intestine.

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“…2E ). It had been reported that UCG-002 was less abundant in the immune thrombocytopenia (ITP) patients and was significantly more prevalent in patients with major depressive disorder ( 34 , 35 ), indicating that UCG-002 was closely related to the health state of the host. Considering that the predicted bacterial functions related to the immune and nervous systems were increased in the colon site in our study, we concluded that the microbes of genus UCG-002 might affect the health of the host by targeting the immune and nervous systems.…”

Section: Discussionmentioning

confidence: 99%

Characterizing bacterial and fungal communities along the longitudinal axis of the intestine in cynomolgus monkeys

Yang,

Xu,

Yao

et al. 2023

Microbiol Spectr

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The gut microbiota develops specialized local communities along the gastrointestinal (GI) tract of the host. Among these microbes, intestinal bacteria and fungi interact closely with the host and play vital roles in their health. However, the gut biogeography of bacteria and fungi has rarely been studied simultaneously, and their correlations have not been reported. In this study, we collected the intestinal luminal contents from different gastrointestinal regions (the ileum, caecum, and colon) of wild-type female cynomolgus monkeys and performed 16S and 18S rRNA gene sequencing to determine the gut biogeography of bacterial and fungal communities. The richness and diversity of bacteria and fungi increased gradually from the small to the large intestine. The bacterial and fungal composition of ileum differed significantly from that of the colon. Specifically, Bacteroidia and Spirochaetia were abundant in the caecum and colon, while Actinobacteria and Cyanobacteria were enriched in the ileum. As for fungal taxa, the genera Aspergillus , Wallemia , and Cryptococcus_f_Tremellaceae were enriched in the colon, while the genus Fusarium was abundant in the caecum. Consequently, the bacterial and fungal functions of the ileum differed from those of the caecum and colon. Notably, we characterized the correlations between intestinal bacteria and fungi at different gastrointestinal regions of cynomolgus monkeys using Spearman correlation analysis. In summary, our results contribute to a more comprehensive understanding of the composition and function of intestinal bacteria and fungi in non-human primates (NHPs) and reveal their correlations along the longitudinal axis of the intestine. IMPORTANCE Gut microbiota varies along the gastrointestinal (GI) tract and exerts profound influences on the host’s physiology, immunity, and nutrition. Given that gut microbes interact with the host closely and the gastrointestinal function differed from the small to the large intestine, it is essential to characterize the gut biogeography of the microbial community. Here, we focused on intestinal bacteria and fungi in cynomolgus monkeys and determined their spatial distribution along the GI tract by performing 16S and 18S rRNA gene sequencing. The composition and function of bacterial and fungal communities differed significantly at different biogeographic sites of the intestine, and the site-specific correlations between intestinal bacteria and fungi were revealed. Thus, our studies characterized the gut biogeography of bacteria and fungi in NHPs and revealed their site-specific correlations along the GI tract.

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Associations of Gut Microbiota and Fatty Metabolism With Immune Thrombocytopenia

Cited by 11 publications

References 62 publications

The causality between gut microbiota and ankylosing spondylitis: Insights from a bidirectional two‐sample Mendelian randomization analysis

The causality between gut microbiota and ankylosing spondylitis: Insights from a bidirectional two‐sample Mendelian randomization analysis

Effect of Echinacea on gut microbiota of immunosuppressed ducks

Characterizing bacterial and fungal communities along the longitudinal axis of the intestine in cynomolgus monkeys

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