Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis

Carmel, Ralph; Aurangzeb, Imran; Qian, Dajun

doi:10.1111/j.1572-0241.2001.03453.x

Cited by 86 publications

(65 citation statements)

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“…The causes for FCM are uncertain. Carmel et al [22] summarized 9 studies in the United States and found that FCM was present in about 40% of patients with unexplained low serum vitamin B12…”

Section: Discussionmentioning

confidence: 99%

An investigation of vitamin B12 deficiency in elderly inpatients in neurology department

et al. 2009

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Objective To investigate the status of vitamin B12 deficiency in elderly inpatients in the department of neurology.Methods A total number of 827 patients in the department of neurology of Shanghai Punan hospital, from March 2007 to July 2008, were employed in the present study. They were 60 years or older, and the average age was 77.1±7.5 years old. All the patients were diagnosed with no severe hepatic or renal dysfunction, without any usage of vitamin B12 during the previous 3 months before the detection. The levels of serum vitamin B12, folate and homocysteine (Hcy) were evaluated. The patients with vitamin B12 deficiency were screened. The resulting symptoms, positive signs of neurological examination, and the neuroelectricphysiological results were compared between patients with or without vitamin B12 deficiency. Results Vitamin B12 deficiency was found in 163 patients (19.71% of the total patients), and was more prevalent in female than in male patients, also with increased incidences with aging. Patients with low levels of serum vitamin B12 exhibited higher rate of gastrointestinal diseases, while only 9.82% of the vitamin B12 deficient patients had megaloblastic anemia. Symptoms of vitamin B12 deficiency included unsteadily walking in the darkness and hypopallesthesia, and some chronic diseases such as cerebral ischemia, hypertension, Parkinson's disease (Parkinsonism), diabetes mellitus and coronary heart disease. Most of the vitamin B12 deficient patients had neuroelectricphysiological abnormalities. Conclusion Vitamin B12 deficiency is remarkably common in elderly patients in neurology department, with various and atypical clinical manifestations, and the neurological symptoms are more common than megaloblastic anemia symptoms.

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Section: Discussionmentioning

confidence: 99%

An investigation of vitamin B12 deficiency in elderly inpatients in neurology department

et al. 2009

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“…Nevertheless in an American study including 202 subjects, Latino-American or Afro-American race, advanced age, and H. pylori infection were shown to be independent risk factors for FCM. Some studies revealed a female preponderance, though this still needs to be confirmed [16].…”

Section: Definition and Physiopathological Rationalementioning

confidence: 94%

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Serraj¹

2011

J Blood Disord Transfus

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SummaryThis article presents recent findings on cobalamin deficiencies due to food-cobalamin malabsorption or nondissociation of vitamin B12 from its carrier proteins syndrome. These findings might be of interest to medical practitioners. This disorder, for which a definitive consensus on the criteria for diagnosis is not yet available, is the leading cause of cobalamin deficiency in the elderly. In practice, food-cobalamin malabsorption is a diagnosis of exclusion, and requires the deductive elimination of all other causes of cobalamin deficiencies, particularly pernicious anaemia. The causes or associated disorders of food-cobalamin malabsorption are multiple and include gastric pathologies, Helicobacter pylori infections and certain drugs (biguanides and proton pump inhibitors). Depending on the disease aetiology, treatment of food-cobalamin malabsorption involves oral supplementation of doses lower than those required for pernicious anaemia.

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“…La principale cause du syndrome de non-dissociation est liée à l'atrophie gastrique, en rapport ou non avec une infection à Helicobacter pylori [24,43]. Dans l'étude de Kaptan et al [43], 40 % des 77 sujets ayant une carence en vitamine B12 liée à H. pylori ont été guéris après un traitement antibiotique adapté.…”

Section: Syndrome De Non-dissociation De La Vitamine B12 Des Protéineunclassified

Carence en vitamine B12 (1^repartie) : mise au point

Loup-Leuciuc

Loup

Lombardi

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 12 mai 2011, accepté le 24 juin 2011) Mots clés : vitamine B12 / métabolisme / carence / manifestationsRésumé -Classiquement, la carence en vitamine B12 s'accompagne d'une anémie mégaloblastique, de manifestations neuropsychiatriques et d'une glossite de Hunter. En réalité, les manifestations sont protéiformes et chacune d'elles peut rester longtemps isolée. Les manifestations stomatologiques, souvent discrètes, peuvent précéder de plusieurs années les autres manifestations. Elles constituent parfois un signe d'appel pour le dépistage précoce de cette carence. Depuis une bonne dizaine d'années, la conception de la physiopathologie de la carence en vitamine B12 a beaucoup évolué : on a identifié le syndrome de non-dissociation de la vitamine B12 des protéines porteuses qui constitue maintenant la principale cause de carence en vitamine B12 et il a été démontré qu'on peut effectuer un traitement de la carence per os. Key words: vitamin B12 / metabolism / deficiency / manifestationsAbstract -Vitamin B12 deficency. Part 1: update and littérature review. Vitamin B12 deficiency is classically accompanied by a megaloblastic anemia, neuropsychiatric disorders and an Hunter glossitis. Clinical manifestations are indeed polymorphic and each may remain the only one for a long period of time. Stomatological manifestations, often mild, may precede the others of many years. They sometimes are the first sign to early diagnose this deficiency. Since the last ten years, the physiopathology of vitamin B12 deficiency has considerably changed. In fact, nowadays, the main cause is the syndrome of food cobalamin malabsorption. It has also been demonstrated that the deficiency may now treated by an oral cobalamin therapy.La vitamine B12 est une vitamine hydrosoluble qui a une structure chimique proche de celle de l'hème avec un atome central constitué par du cobalt, d'où le nom de cobalamine (Fig. 1).Elle existe sous plusieurs formes regroupées dans la famille des cobalamines : cyanocobalamine, hydroxocobalamine, mé-thylcobalamine et adénosylcobalamine. La cyanocobalamine et l'hydroxocobalamine sont les seules formes stables. On peut considérer que les recherches sur la vitamine B12 ont commencé au XIX e siècle avec la description d'une anémie mortelle, l'anémie pernicieuse, par Thomas Addison et Michael Anton Biermer. Vers 1920, George Whipple, George Minot et William Murphy, tous les trois Prix Nobel de médecine en 1934, ont démontré que des extraits de foie sous forme de compléments alimentaires étaient susceptibles de corriger certaines anémies. On en a conclu que les extraits de foie contenaient le facteur extrinsèque, en réalité de la vitamine

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Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis

Cited by 86 publications

References 31 publications

An investigation of vitamin B12 deficiency in elderly inpatients in neurology department

An investigation of vitamin B12 deficiency in elderly inpatients in neurology department

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Carence en vitamine B12 (1^repartie) : mise au point

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Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis

Cited by 86 publications

References 31 publications

An investigation of vitamin B12 deficiency in elderly inpatients in neurology department

An investigation of vitamin B12 deficiency in elderly inpatients in neurology department

The Syndrome of Food-Cobalamin Malabsorption: A Personal View in a Perspective of Clinical Practice

Carence en vitamine B12 (1repartie) : mise au point

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Carence en vitamine B12 (1^repartie) : mise au point