Associations of Body Mass Index and Body Height With Low Back Pain in 829,791 Adolescents

Hershkovich, Oded; Friedlander, A.; Gordon, Barak; Arzi, Harel; Derazne, Estela; Tzur, Dorit; Shamis, Ari; Afek, Arnon

doi:10.1093/aje/kwt019

Cited by 79 publications

(50 citation statements)

References 22 publications

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“…Some studies already demonstrated larger body height as a risk factor for future LBP (Coeuret-Pellicer et al, 2010;Hershkovich et al, 2013). This could not be confirmed by the current study since the variable height was not significant in the regression analysis.…”

Section: No Lbp -No Lbpcontrasting

confidence: 92%

Young individuals with a more ankle-steered proprioceptive control strategy may develop mild non-specific low back pain

Claeys

Dankaerts

Janssens

et al. 2015

Journal of Electromyography and Kinesiology

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Altered proprioceptive postural control has been demonstrated in people with non-specific low back pain (LBP). However, the cause-effect relation remains unclear. Therefore, more prospective studies are necessary. Proprioceptive postural control of 104 subjects was evaluated at baseline using a force plate and with application of vibration stimulation on ankle and back muscles. Spinal postural angles were measured with digital photographs. Psychosocial variables and physical activity were registered using questionnaires. Ninety subjects were followed over two years concerning their LBP status, 14 were lost to follow-up. Four distinct groups were determined after two years based on pain and disability scores: never LBP, no LBP at intake with future mild LBP, mild LBP at intake with no further LBP, LBP at intake with further episodes of mild LBP. Risk factors for developing or sustaining LBP were calculated using logistic regression analysis. A more ankle-steered proprioceptive postural control strategy in upright standing increased the risk for developing or having recurrences of mild LBP within two years (Odds: 3.5; 95% CI: 1.1-10.8; p < 0.05). Increased postural sway, altered spinal postural angles, psychosocial and physical activity outcomes were not identified as risk factors for future mild LBP. These findings could contribute to improving the prevention and rehabilitation of LBP.

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Section: No Lbp -No Lbpcontrasting

confidence: 92%

Young individuals with a more ankle-steered proprioceptive control strategy may develop mild non-specific low back pain

Claeys

Dankaerts

Janssens

et al. 2015

Journal of Electromyography and Kinesiology

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“…This has important consequences in both fundamental science, for example, in genome-wide association study design, and applied science, such as pharmacogenetic development of novel analgesics. Covariates such as BMI with highly significant association as observed in the present study, but also by others (e.g., Hershkovich et al, 2013), may have little practical gene-finding significance due to their modest contribution to risk of the disease manifestation.…”

Section: Discussionsupporting

confidence: 52%

Low Back and Common Widespread Pain Share Common Genetic Determinants

Malkin

Williams

Lachance

et al. 2014

Annals of Human Genetics

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SummaryLow back (LBP) and chronic widespread musculoskeletal pain (CWP) both have a significant genetic component and are associated with increased body mass index (BMI). We examined whether LBP and CWP share common genetic factors, and to what extent this correlation is modified by the genetic factors influencing BMI. Genetic analysis of binary traits such as pain is not simple, particularly if their risk is associated with age or other quantitative traits. Implementing Falconer's polygenic threshold concept for dichotomous traits inheritance, we developed new software to examine the extent of the genetic influence on LBP and CWP under age and BMI dependence. The analysis was conducted on 3266 and 2256 UK female twins, assessed for LBP and CWP, respectively. Analysis of the liability scores with threshold to LBP and CWP established substantial contribution of genetic factors to their variation (h 2 > 0.60, p<0.004-0.0003) and covariation (p=3.1E-08). Some 39% of the CWP and 70% of the LBP heritability estimates were attributable to genetic effects shared by both phenotypes, and 40% and 67% of the residual variation is caused by environmental factors simultaneously affecting both pain syndromes. However, contribution of BMI to variation/covariation of both pain phenotypes-although statistically highly significant (pß10-7)-was not determinative.

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“…To preserve anonymity of participants, demographic information was limited to age and Body Mass Index (BMI), which have been identified as risk factors for musculoskeletal pain in the general population [8,15,16]. The hours per week spent on five activities were used to assess lifestyle of medical students: Exercising, sleeping, studying, sitting and walking.…”

Section: Surveymentioning

confidence: 99%