Associations of Bilateral Vestibulopathy With Cognition in Older Adults Matched With Healthy Controls for Hearing Status

Bosmans, Joyce; Gommeren, Hanne; Mertens, Griet; Cras, Patrick; Engelborghs, Sebastiaan; Ombergen, Angelique Van; Vereeck, Luc; Gilles, Annick; Rompaey, Vincent Van

doi:10.1001/jamaoto.2022.1303

Cited by 18 publications

(24 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Visuospatial deficits associated with vestibular loss have consistently been observed in animal (Baek et al, 2010;Smith et al, 2015;Smith & Zheng, 2013;Zheng et al, 2007Zheng et al, , 2009 and human studies (Bosmans et al, 2022;Brandt et al, 2005;Dobbels, Peetermans, et al, 2019).…”

Section: Introductionmentioning

confidence: 85%

“…Visuospatial cognition encompasses spatial memory, mental rotation, navigation, and mental representation in three-dimensional space (Bigelow & Agrawal, 2015; Dobbels, Peetermans, et al, 2019). Visuospatial deficits associated with vestibular loss have consistently been observed in animal (Baek et al, 2010; Smith et al, 2015; Smith & Zheng, 2013; Zheng et al, 2007, 2009) and human studies (Bosmans et al, 2022; Brandt et al, 2005; Dobbels, Mertens, et al, 2019; Dobbels, Peetermans, et al, 2019).…”

Section: Introductionmentioning

confidence: 89%

“…There is evolving evidence suggesting that vestibular loss is associated with cognitive impairment and may even contribute to the onset of Alzheimer’s disease (Bigelow & Agrawal, 2015; Bosmans et al, 2022; Bosmans et al, 2021; Harun et al, 2016; Previc, 2013; Semenov et al, 2016). Recent literature points to a significant impact of the vestibular system on cognitive function, specifically its impact on visuospatial processing.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is vestibular function related to human hippocampal volume?

Bosmans

Gommeren

Eulenburg³

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

INTRODUCTION: Recent studies implicate the effect of vestibular loss on cognitive decline, including hippocampal volume loss. As hippocampal atrophy is an important biomarker of Alzheimer′s disease, exploring vestibular dysfunction as a risk factor for dementia and its role in hippocampal atrophy is of interest. METHODS: Hippocampal and whole-brain MRI volumes were compared in adults aged between 55 and 83 years: (1) to substantiate previous literature, bilateral vestibulopathy (BV) was compared to healthy controls, (2) to correct for a potential confounding effect of concomitant hearing loss, BV was compared to healthy controls matched on age, sex, and hearing status, (3) to additionally evaluate the isolated effect of hearing loss on brain structure, sensorineural hearing loss (SNHL) was compared to healthy controls. Furthermore, to delineate otolith influence on hippocampal volume in preserved vestibular function (healthy controls and SNHL combined), saccular function was investigated. RESULTS: Whole-brain and targeted hippocampal approaches using volumetric and surface-based measures yielded no significant differences in either of three comparisons: (1) BV versus controls, (2) BV versus matched controls, and (3) SNHL versus controls. Binary support vector machines were unable to classify inner ear health status above chance level. Otolith parameters were significantly associated with hippocampal volume in preserved vestibular function. CONCLUSION: No significant differences in whole-brain or hippocampal volume were found when comparing BV with healthy controls, nor did concomitant SNHL confound this relationship. Otolith function may be associated with hippocampal volume rather than lateral semicircular canal integrity. Future BV studies should generally incorporate otolith function testing.

show abstract

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is vestibular function related to human hippocampal volume?

Bosmans

Gommeren

Eulenburg³

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In recent years, there has been evolving evidence of the association between cognitive impairment and vestibular dysfunction, especially common in chronic vestibular syndromes, such as MD ( Hitier et al, 2014 ; Bigelow and Agrawal, 2015 ; Harun et al, 2015 ; Aitken et al, 2016 ; Bigelow et al, 2016 , 2020 ; Benoit et al, 2018 ; Dobbels et al, 2019 ; Liu et al, 2019 ; Rizk et al, 2020 ; Chari et al, 2021 ; Dornhoffer et al, 2021 ; Bosmans et al, 2022 ). Various studies have directly or indirectly demonstrated the presence of cognitive dysfunction in MD patients.…”

Section: Discussionmentioning

confidence: 99%

“…As one of the emergencies in clinical practice with increasing morbidity, MD not only limits activities of daily living (ADL) but also raises the risk of drop attacks. Recently, a growing body of findings suggested that patients with MD and other vestibulopathy may also experience cognitive decline, further decreasing quality of life and social functioning ( Bigelow and Agrawal, 2015 ; Harun et al, 2015 ; Bigelow et al, 2016 , 2020 ; Dobbels et al, 2019 ; Liu et al, 2019 ; Rizk et al, 2020 ; Chari et al, 2021 ; Dornhoffer et al, 2021 ; Bosmans et al, 2022 ). In fact, cognitive complaints in patients with vestibular symptoms are far from rare, even during vertigo intervals, they may suffer “brain fog” in the form of dullness, difficulty concentrating, poor memory or confusion ( Bigelow et al, 2020 ; Chari et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of cognitive function and its related factors after treatment in Meniere’s disease

Zhong

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere’s disease (MD), a common clinical vestibular disorder, is usually accompanied by hearing loss and emotional stress, both of which may mediate the relationship between vestibule dysfunction and cognition. It is currently unknown whether the cognitive decline in MD patients could improve through treatment and how it relates to multiple clinical characteristics, particularly the severity of vertigo. Therefore, in the present study, the MD patients were followed up for 3, 6, and 12 months after treatment, and the cognitive functions, vertigo symptoms, and related physical, functional, and emotional effects of the patients were assessed using the Montreal Cognitive Assessment (MoCA) and Dizziness Handicap Inventory (DHI), aiming to explore the change in cognition before and after therapy and the correlation with various clinical features. It was found that cognitive decline in MD patients compared to healthy controls before therapy. Importantly, this cognitive impairment could improve after effective therapy, which was related to the severity of vertigo, especially in functional and physical impacts. Our results support the view that vestibular dysfunction is a potentially modifiable risk factor for cognitive decline.

show abstract

Association of Bilateral Vestibulopathy With and Without Hearing Loss With Cognitive-Motor Interference

Danneels

Hecke

Leyssens

et al. 2023

JAMA Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

ImportanceThe past years, evidence suggested that the primary symptoms traditionally associated with bilateral vestibulopathy (BV) do not represent the full picture of this patient population. Recent literature also demonstrated cognitive impairment. However, although multitasking and dual-tasking are widely present in everyday activities, most of these studies assessed cognitive function only in single-task conditions.ObjectiveTo uncover the association of BV with and without hearing loss with cognitive and motor performance and cognitive-motor interference.Design, Setting, and ParticipantsThis prospective case-control study assessed persons with an isolated BV and persons with BV and a concomitant hearing loss compared with a healthy control group. Data were analyzed in December 2022. The study was conducted at Ghent University (Ghent, Belgium). Data collection took place between March 26, 2021, and November 29, 2022.Main Outcomes and MeasuresAll participants completed the 2BALANCE dual-task protocol, comprising a static and a dynamic motor task that was combined with 5 visual cognitive tasks. These cognitive tasks assessed mental rotation, visuospatial memory, working memory, response inhibition (executive function), and processing speed. All cognitive tasks were performed in a single-task condition (while seated) and in a dual-task condition (combined with a static and a dynamic motor task). The static task comprised balancing on a force platform with foam pad, and the dynamic task comprised walking at a self-selected speed on the GAITRite Walkway. Both motor tasks were performed in the single-task and dual-task condition.ResultsNineteen persons with BV and hearing loss (mean [SD] age, 56.70 [10.12] years; 10 women [52.6%]), 22 persons with an isolated BV (mean [SD] age, 53.66 [13.35] years; 7 women [31.8%]), and 28 healthy control participants were included (mean [SD] age, 53.73 [12.77] years; 12 women [42.9%]). Both patient groups had mental rotation and working memory impairment in a single-task condition and slower processing speed when walking (ie, during the dynamic dual-task condition). Additionally, the patient group with hearing loss had impaired visuospatial memory and executive function deficits in single-task and dual-task conditions, while this could only be elicited when performing a motor task in persons with isolated BV (ie, when dual-tasking).Conclusion and RelevanceThe findings of this case-control study suggest an association between vestibular function and cognitive and motor performance, even greater in persons with a concomitant hearing loss than in persons with an isolated BV.

show abstract

Associations of Bilateral Vestibulopathy With Cognition in Older Adults Matched With Healthy Controls for Hearing Status

Cited by 18 publications

References 77 publications

Is vestibular function related to human hippocampal volume?

Is vestibular function related to human hippocampal volume?

Analysis of cognitive function and its related factors after treatment in Meniere’s disease

Association of Bilateral Vestibulopathy With and Without Hearing Loss With Cognitive-Motor Interference

Contact Info

Product

Resources

About