Associations of Age, Gender, and BMI with Prevalence of Allergic Diseases in Children: PATCH Study

Yao, Tsung‐Chieh; Ou, Liang-Shiou; Yeh, Kuo‐Wei; Lee, Wen-I; Chen, Li‐Chen; Huang, Jing‐Long

doi:10.3109/02770903.2011.576743

Cited by 107 publications

(98 citation statements)

References 29 publications

(32 reference statements)

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“…The study subjects were enrolled from the Prediction of Allergies in Taiwanese CHildren (PATCH) study, a population-based cohort study that was launched in 2007 to investigate the epidemiology and predictive factors of asthma and allergies in children [11]. The subject flow diagram is presented in figure 1.…”

Section: Subject Recruitmentmentioning

confidence: 99%

Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years

Yao

Wi²,

Ls³

et al. 2011

European Respiratory Journal

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This study was undertaken to establish reference values of exhaled nitric oxide fraction (FeNO) and its determinants in healthy Asian children.693 healthy Asian children aged 5-18 yrs were assessed using a single-breath online FeNO measurement (exhaled flow 50 mL?s -1 ), questionnaires, anthropometric measurements, spirometry and total and specific immunoglobulin (Ig) E.Geometric mean FeNO and the upper 95% CI were 13.7 ppb and 49.7 ppb, respectively, for healthy children, and 11.2 ppb and 30.2 ppb, respectively, for those without allergic sensitisation. FeNO was positively associated with age, allergic sensitisation, total IgE, ambient nitric oxide, measurement in the afternoon, and drinking water within 1 h before testing, and was negatively associated with weight. In healthy children without allergic sensitisation, age was the single best explanatory variable. The FeNO predicted values were 1-2 ppb higher in Asian than in Caucasian children in earlier studies, while the upper 95% CI were 9-10 ppb higher.In conclusion, the upper limits of normal FeNO in Asian children depend on age, from 21 ppb in young children to 39 ppb in adolescents. Ethnicity, age, allergic sensitisation, total IgE, ambient nitric oxide, time of testing, drinking water and weight are important determinants.

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Section: Subject Recruitmentmentioning

confidence: 99%

Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years

Yao

Wi²,

Ls³

et al. 2011

European Respiratory Journal

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“…Paramesh H7 studied prevalence of asthma in children below 18 years of age over 2 decades in the city of Bangalore and reported 64% male prevalence and 36% female prevalence. In a study carried out by Yao TC et al 8 among Taiwanese children aged 4-18 years, male-tofemale prevalence ratios of current wheeze increased with age from <1 at 4-5 years, peaked at 10-11 years (2.24), then reversed to 0.57 at 16-18 years. When examined at specific time points, asthma is more common and more severe in pre-pubertal boys, with boys less than 18 years of age having a 54% higher rate of asthma than girls of the same age.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of spirometry in asthmatic children

Hegde¹,

Saxena²,

Kumar³

2017

Int J Contemp Pediatr

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Background:The use of spirometry in the assessment of children with asthma is taking on new importance with the realization that considerable airway obstruction may exist in the absence of clinically detectable abnormalities. Hence this study was planned to evaluate, forced expired volume in 1 second (FEV1), forced vital capacity (FVC), the forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) and Peak Expiratory Flow rates (PEFR) in asthmatic children aged 6-12 years. The objective of the study was to determine prevalence of asthma according to clinical classification and identify common trigger factors and to determine which is more sensitive between FEV1, FVC, FEV1/FVC, FEF 25-75 and PEFR in different age groups.Methods: The present study was conducted among 60 patients of age group 6 to 12 years with asthma. Forced vital capacity (FVC), Forced expiratory volume in 1 second (FEV1), Ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC), PEFR and Forced expiratory flow between 25-75% were recorded. Data was analyzed using chi-square test, Karl Pearson’s correlation coefficient. Level of significance was set at 5%. All p values less than 0.05 were treated as significant.Results:In Age and Sex wise correlation with classification of asthma, a male preponderance was seen in all the age groups i.e. between 6-8 years, 9-10 years and 11-12 years. Mosquito coils were the most common indoor agents to trigger an asthmatic accounting for nearly 80%. Amongst the outdoor triggers, exacerbation of symptoms during the cold weather accounted for 90 % followed by variation during festivals like Diwali, dust, pollution, exercise and insects. Comparison of Pre and Post bronchodilator FEF 25-75 values have shown a high statistical significance.Conclusions:Parents need to be educated regarding certain modifiable factors that can improve the prognosis. Pulmonary Function tests should be performed as a routine office procedure. Peak expiratory flow meter is a handy instrument. In all children above 6 years of age suspected to have asthma, this test should be performed before beginning therapy.

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“…Previous studies reported that higher BMI and being overweight were risk factors for asthma/wheezing and allergic diseases in children from Japan, Taiwan and the UK, countries where childhood obesity is an increasing public health concern (7)(8)(9)(10) . Little evidence exists, however, on the potential association between undernutrition and current wheezing/ asthma and allergic diseases.…”

mentioning

confidence: 98%

Nutritional status and childhood wheezing in rural Bangladesh

Hawlader

Noguchi

Arifeen

et al. 2013

Public Health Nutr.

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Objective: To investigate the association between current childhood nutritional status and current wheezing among pre-school children in rural Bangladesh. Design: Cross-sectional study. Setting: Matlab region, rural Bangladesh. Subjects: Children (n 912) aged 4?5 years. Anthropometric measurements of the mothers and their children were taken during a 1-year period from December 2007 to November 2008. Current wheezing was identified using the International Study of Asthma and Allergies in Childhood questionnaire. Serum total IgE was measured by human IgE quantitative ELISA. IgE specific antibody to dust mites (Dermatophagoides pteronyssinus) was measured by the CAP-FEIA system (Phadia AB, Uppsala, Sweden). Results: Wheezing at 4?5 years old was significantly associated with stunting (OR 5 1?58; 95 % CI 1?13, 2?22) and underweight (OR 5 1?39; 95 % CI 1?00, 1?94). The association with stunting remained significant after adjustment for sex, birth weight, birth length, gestational age at birth, mother's parity, maternal BMI, family history of asthma, socio-economic status, season of birth and intervention trial arm (OR 5 1?74; 95 % CI 1?19, 2?56). Conclusions: Stunting was a significant risk factor for wheezing among rural Bangladeshi children. Further studies will be required to confirm the relationship between nutritional status and allergic illnesses in developing countries.

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Associations of Age, Gender, and BMI with Prevalence of Allergic Diseases in Children: PATCH Study

Cited by 107 publications

References 29 publications

Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years

Reference values of exhaled nitric oxide in healthy Asian children aged 5 to 18 years

Evaluation of spirometry in asthmatic children

Nutritional status and childhood wheezing in rural Bangladesh

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