Associations between urinary caffeine and caffeine metabolites and cognitive function in older adults

Fu, Xihang; Li, Huiru; Chen, Xinzhen; Cai, Jinliang; Yao, Tianxiang; Song, Lingling; Cen, Man-qiu; Wu, Jing

doi:10.1080/1028415x.2022.2071809

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…Studies have shown that coffee is currently consumed by many age groups in the U.S. population and that daily caffeine intake is relatively stable over the week, with no significant differences between weekdays and weekend days 9 . Several diseases have been reported to be associated with caffeine consumption, including bone density issues, high blood pressure, cardiovascular disease, reproductive and developmental abnormalities, mental and behavioral disorders, and various cancers 10 , 11 . Caffeine is a central nervous system stimulant and is believed to provide health benefits in cardiovascular, cerebrovascular, and neurological diseases 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Fan¹,

Yuan²,

Zhang³

et al. 2023

Sci Rep

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This study investigates the potential correlation between urinary caffeine levels and the occurrence of stroke, a serious cerebrovascular disease that can lead to disability or death. The data used in this study was obtained from the National Health and Nutrition Examination Survey conducted between 2009 and 2014. The study analyzed a total of 5,339 individuals, divided into a control group (n = 5,135) and a stroke group (n = 162). The researchers utilized multiple logistic regression and smoothed curve fitting to examine the relationship between urinary caffeine and caffeine metabolites and the incidence of stroke. The study found that higher urinary caffeine levels were associated with a lower risk of stroke in Mexican American participants (odds ratio [OR] = 0.886, 95% confidence interval [CI]: (0.791, 0.993), P = 0.037). After adjusting for certain participant characteristics, it was also found that higher urinary paraxanthine levels were associated with a lower risk of stroke incidence (OR = 0.991, 95% CI (0.984, 0.999), P = 0.027). Meanwhile, the highest urinary paraxanthine levels group had 43.7% fewer strokes than the lowest level group (OR = 0.563, 95% CI (0.341, 0.929), P = 0.025). In this study, we showed a negative link between urine paraxanthine levels and the risk of stroke. Meanwhile, urinary caffeine levels were negatively associated with the incidence of stroke in Mexican Americans, but no correlation in other populations. Our findings may have predictive and diagnostic implications in clinical practice. Further extensive prospective investigations are still needed to validate our conclusions.

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Section: Introductionmentioning

confidence: 99%

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Fan¹,

Yuan²,

Zhang³

et al. 2023

Sci Rep

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“…Until now, there were no standard cut-off points in the CERAD W-L, AFT, and DSST. According to previous papers, we classified the scores into quartiles and defined the minimum quartile for each test as the reference group [ 20 , 27 , 28 ]. Regarding the CERAD W-L, AFT, and DSST scores, the cut-off values were 20, 12, and 33, respectively.…”

Section: Methodsmentioning

confidence: 99%

Association of Dietary α-Carotene and β-Carotene Intake with Low Cognitive Performance in Older Adults: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

et al. 2023

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This study aims to examine the relationships of dietary α-carotene and β-carotene intake with cognitive function. The data were selected from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. A total of 2009 participants were included in this analysis. Dietary α-carotene and β-carotene intake were averaged by two 24-h dietary recalls. The Consortium to Establish a Registry for Alzheimer’s Disease Word Learning subset (CERAD W-L), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST) were used to evaluate cognitive function. Logistic regression and restricted cubic spline models were applied to explore the associations of dietary α-carotene and β-carotene intake with cognitive performance. After adjusting for all confounding factors, compared with individuals in the lowest quartile of β-carotene dietary intake, those in the highest quartile had lower risks of both CERAD W-L decline [odds ratio (OR) = 0.63, 95% confidence interval (CI): 0.44–0.90] and AFT decline (OR = 0.66, 95% CI: 0.47–0.94). In addition, the third quartile of β-carotene dietary intake had a significantly decreased risk of lower DSST (OR = 0.67, 95% CI: 0.48–0.83). Compared with the lowest quartile of α-carotene intake, the OR of AFT decline in the highest intake quartile was 0.66 (95% CI: 0.46, 0.94). For males, both dietary α-carotene and β-carotene intake were associated with a decreased risk of AFT decline (OR = 0.42, 95% CI: 0.25–0.71; OR = 0.51, 95% CI: 0.30–0.85, respectively). For females, dietary α-carotene intake was associated with a decreased risk of CERAD W-L decline (OR = 0.55, 95% CI: 0.33–0.91) and dietary β-carotene intake was associated with decreased risks of both CERAD W-L and AFT decline (OR = 0.37, 95% CI: 0.21–0.64; OR = 0.58, 95% CI: 0.37–0.91, respectively). Our results suggested that higher dietary α-carotene and β-carotene intake had inverse effects on cognitive function decline among older adults.

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Coffee and brain health: An introductory overview

Raza

2024

Progress in Brain Research

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Associations between urinary caffeine and caffeine metabolites and cognitive function in older adults

Cited by 5 publications

References 48 publications

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Association of Dietary α-Carotene and β-Carotene Intake with Low Cognitive Performance in Older Adults: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

Coffee and brain health: An introductory overview

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