Associations Between Three Polymorphisms in the Interleukin-4 Receptor Gene and Risk of Cancer: a Meta-analysis

Wang, Jiayi; Zhou, Yuqiao; Li, Xiaoxu; Jin, Xin; Wang, Lili; Lei, Lei; Zhou, Yu; Jiang, Lu; Zeng, Xiansheng; Dan, Hongxia; Liao, Ga; Chen, Qianming

doi:10.7314/apjcp.2012.13.12.6227

Cited by 3 publications

(2 citation statements)

References 33 publications

(33 reference statements)

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“…IL-4 Rp1/Rp2 gene polymorphism is also reported to be associated with an increased risk of cervical cancer (Shekari et al, 2012). In a large meta-analysis of IL-4 R (Interleukin-4 Receptor) polymorphism Wang et al (2012) observed reduced risk of cervical cancer in Q576R G allele carriers.…”

Section: Il-4mentioning

confidence: 99%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiple small molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism, was initially a great challenge. Advances in analytical chemistry and molecular biology have made it possible to unravel the pathophysiological functions of these polypeptides/proteins which are called interleukins, chemokines, monokines, lymphokines and growth factors. With more than 5 million women contracting cervical cancer every year this cancer is a major cause of mortality and morbidity the world over, particularly in the developing countries. In more than 95% of cases it is associated with human papilloma virus (HPV) infection which is persistent, particularly in those with a defective immune system. Although preventable, the mere magnitude of prevalence of HPV in the world population makes it a dominating current health hazard. The discovery of cytokine dysregulation in cervical cancer has spurted investigation into the possibility of using them as biomarkers in the early diagnosis of cases at high risk of developing cancer. Their critical role in carcinogenesis and progression of cervical cancer is now being revealed to a great extent. From diagnostics to prognosis, and now with a possible role in therapeutics and prevention of cervical cancer, the cytokines are being evaluated in all anticancer approaches. This review endeavours to capture the essence of the astonishing journey of cytokine research in cervical neoplasia.

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Section: Il-4mentioning

confidence: 99%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Cho et al 50 demonstrated a reduced risk of GC for rs1801275, but they mixed the gastric cancer, esophageal cancer, pancreatic cancer and colorectal cancer, without any subgroup analysis of cancer type. Wang et al 51 performed a meta-analysis about IL-4R and cancer risk on rs1801275, rs1805010 and rs1805015, however, they only enrolled 36 studies, and didn't adjust the P value of Q-test, which might lead to statistical error.…”

Section: Discussionmentioning

confidence: 99%

Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies

Zeng

Fan

et al. 2019

J. Cancer

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Polymorphisms in interleukin-4 receptor (IL-4R) gene have been reported susceptible to a variety of cancer types, nevertheless, data from these publications remained inconsistent and controversial. We further performed a comprehensive meta-analysis to present a precise estimation of its relationship. Extensive retrieve was performed in PubMed, Google Scholar and Web of Science up to May 25, 2018. Odds ratios (ORs) and 95% confidence intervals (CIs) were conducted to evaluate the overall strength of the associations in five genetic models, as well as in subgroup analyses, stratified by ethnicity, cancer type or source of control. Q-test, Egger's test and Begg's funnel plot were applied to evaluate the heterogeneity and publication bias. In-silico analysis was managed to demonstrate the relationship of IL-4R expression correlated with cancer tissues. Finally, 31 publications including 53 case-control studies were enrolled, with 24,452 cases and 24,971 controls. After a comprehensive analysis, no significant evidence was revealed for the association between four IL-4R polymorphisms (rs1801275, rs1805010, rs1805015, rs2057768) and cancer susceptibility in the overall population, as well as the subgroup analysis stratified by ethnicity, cancer type, the genotyping method or the source of control. To sum up, no evidence was identified between IL-4R polymorphisms and overall cancer susceptibility. Further well-designed studies with large sample sizes will be continued on this issue of interest.

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Polymorphism rs4787951 in IL-4R contributes to the increased risk of renal cell carcinoma in a Chinese population

Lin

Qian

et al. 2019

Gene

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Associations Between Three Polymorphisms in the Interleukin-4 Receptor Gene and Risk of Cancer: a Meta-analysis

Cited by 3 publications

References 33 publications

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies

Polymorphism rs4787951 in IL-4R contributes to the increased risk of renal cell carcinoma in a Chinese population

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