Associations Between Systemic Status, Periodontal Status, Serum Cytokine Levels, and Delivery Outcomes in Pregnant Women with a Diagnosis of Threatened Premature Labor

Hasegawa, K; Furuichi, Yasushi; Shimotsu, Akihiro; Nakamura, Masahiro; Yoshinaga, Mitsuhiro; Kamitomo, Masato; Hatae, Masayuki; Maruyama, Ikuro; Izumi, Yuichi

doi:10.1902/jop.2003.74.12.1764

Cited by 92 publications

(84 citation statements)

References 32 publications

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“…Unlike other published studies, we did not find significantly increased levels of IL-6, IL-8 and TNF-α in women delivering preterm [47,48]. There is a vast controversy in the literature regarding cytokine profiles and PTB.…”

Section: Page 7 Ofcontrasting

confidence: 99%

“…This allows us to compare whether differences observed in oral and cord samples in women with early PTB were also present in women with periodontitis. Hasegawa et al have been the only group to also compare the association between periodontal status, serum cytokine levels and delivery outcomes in 88 women [48]. They found that women with threatened preterm labour had worsened periodontal status, significantly higher levels of Tf in oral samples, and significantly higher levels of serum IL-8 and IL-1β versus women without it.…”

Section: Page 7 Ofmentioning

confidence: 99%

See 1 more Smart Citation

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

M¹,

Gayet-Ageron²,

Roux‐Lombard³

et al. 2017

Gynecol Obstet

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Citation: Lumbreras Areta M, Gayet-Ageron A, Roux-Lombard P, Schrenzel J, AbstractBackground: Comparing microbiologic and inflammatory markers of periodontitis with those of preterm birth (PTB).Methods: Secondary analysis of a prior prospective case-control study done at the Geneva University Hospitals. Cases were women delivering at 22-34 6/7 weeks (early PTB, n=30) and controls were women delivering at ≥ 37 weeks (term delivery, n=87). We collected dental plaque during labour to quantify RNA levels from Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Porphyromonas gingivalis (Pg) and Treponema denticola (Td). We also collected cord blood for cultures and cytokine quantification (IL-1Ra, IL-6, IL-8, IL-10, IL-17, TNF-α, MCP-1 and RANTES). Periodontal status was evaluated at the immediate postpartum using the American Consensus definition. Data was analysed by univariate and multivariate logistic regression.Results: Levels of Pg and Td were significantly higher in dental plaque of women with severe and moderate periodontitis. Microbiologic composition of dental plaque was not different between preterm and term delivery groups. There were no differences in cord blood cultures between groups. Cord TNF-α ≥ 8 pg/ml and IL-10 ≥ 1.3 pg/ml were associated with a higher risk of periodontitis (OR 2.78, 95% CI: 1.09-7.13, P=0.033; OR 2.78, 95% CI: 1.09-7.08, P=0.032 respectively), but differences were not significant at multivariate analysis. Cord MCP-1 ≥ 350 pg/ml was associated with a higher risk of PTB at both univariate (OR 40.25, P<0.001) and multivariate analysis (OR 53.71, P<0.001). Conclusion:In labour, microbiologic markers and inflammatory responses associated with periodontitis and PTB are different. The mechanisms linking periodontitis and PTB therefore still need to be elucidated. Page 2 of 9Citation: Lumbreras Areta M, Gayet-Ageron A, Roux-Lombard P, Schrenzel J, 2.38, 95% CI: 1.36-4.14, P=0.002) [20]. In this secondary analysis, we aim to compare the type of bacteria (in dental plaque and cord blood) and cytokines/chemokines (in cord blood) in women with severe periodontitis with those in women with early PTB. The objective is to determine if the microbiological and/or inflammatory pathways in periodontitis are the same as those involved in early PTB. A shared molecular pathway would explain the aetiology of the association between periodontitis and increased risk of PTB that was observed in our previous study. Methods Study designThis is a planned secondary analysis of women included in a prior prospective case-control (1:4) study performed between 09 November, 2007 and 18 March, 2010 at the maternity unit of the Geneva University Hospitals, Switzerland [20]. Briefly, the study evaluated the association of periodontitis in cases (women delivering spontaneously between 22 and 34, 6/7 weeks of gestation) compared to controls (women delivering as term [≥ 37 weeks]). The study was approved by the Ethics Committee of Geneva (study number 07-008, approved 28 March 2007). All partic...

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Section: Page 7 Ofcontrasting

confidence: 99%

Section: Page 7 Ofmentioning

confidence: 99%

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

M¹,

Gayet-Ageron²,

Roux‐Lombard³

et al. 2017

Gynecol Obstet

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“…Our findings therefore suggest that the AOSD patients produced inflammatory cytokines with predominant Th1-type immunity, and intensive LCAP treatment corrected the Th1/Th2 cytokine balance, thus resulting in the induction of tolerance. IL-8 plays an important role in pregnancy and promotes neutrophil recruitment and angiogensesis (22,23). Elevated levels of IL-8 in the cervical fluid and serum were found to be correlated with threatened premature delivery.…”

Section: Discussionmentioning

confidence: 96%

Therapeutic Efficacy of Leukocytapheresis in a Pregnant Woman with Refractory Adult-onset Still's Disease

et al. 2015

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This is the first report of the efficacy of leukocytapheresis (LCAP) in a patient with refractory adult onset Still's disease (AOSD) during pregnancy. A 32-year-old Chinese pregnant woman with AOSD who had been treated with prednisolone failed to achieve disease stabilization. The patient's disease was successfully controlled with the initiation of LCAP. Subsequently, she gave birth via Caesarean section to a 1,878 g baby boy at 34 weeks of gestation while maintaining remission. We conclude that LCAP is an alternative treatment in pregnant patients with refractory AOSD, particularly in those concerned about potential teratogenic and other adverse effects.

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“…-le poids du nouveau-né [25][26][27][28][29][30][31][32][33][34] ; -la prématurité telle qu'elle a été définie précédemment (accouchement avant 37 SA quel que soit le poids du nouveau-né) [29][30][31][32][33][34][35][36][37][38][39][40] ;…”

Section: Définition De La Prématuritéunclassified

“…On fait l'hypothèse que le processus inflammatoire et les bactériémies seraient à l'origine de prématurités. Ce dernier axe de recherche semble prometteur [21,25,36,39,80,81].…”

Section: Approche Biologiqueunclassified

Lien entre parodontopathies et prématurité : analyse critique de 15 ans de recherche

Gunepin¹,

Derache

2010

Med Buccale Chir Buccale

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Mots clés :parodontopathie / grossesse / accouchement prématuré Résumé -En raison du taux d'incidence élevé, de la gravité des complications, de la lourdeur de la prise en charge et des possibilités en terme de prévention, les nouveau-nés prématurés représentent un des domaines d'intérêt pour la recherche médicale. La médecine bucco-dentaire prend part à ces travaux de recherche depuis 1996 en essayant de déterminer l'existence d'un lien entre les maladies parodontales et la prématurité. Nous proposons ici une revue critique de la littérature internationale portant sur les travaux tendant à établir l'existence de ce lien, à la fois sur la forme (méthodologie) et sur le fond (conclusions). Toute tentative de méta-analyse et d'élaboration de recommandations achoppe sur le caractère individuel de chaque étude car les critères utilisés pour définir la maladie parodontale et la prématurité sont diffé-rents ce qui conduit inéluctablement à des conclusions divergentes. Cependant, en étudiant la bactériémie et l'inflammation spécifiques des maladies parodontales et leurs conséquences sur la grossesse, la biologie semble constituer un axe de recherche prometteur qui devrait permettre de préciser le lien entre maladie parodontale et prématurité. Key words:periodontal disease / pregnancy / preterm birth Abstract -Periodontal diseases and preterm birth: a review of 15 years of medical research. The delivery of preterm babies (under 37 weeks f gestation) is a significant public health issue. This problem is associated with both high postnatal mortality rate and higher risk of morbidity due to sequelae. Despite clinical researches, in 40% of cases, aetiology of preterm birth remains unknown and the preterm birth rates have not only not declined but also have increased over the last two decades (7% in France, 13% in the United States).

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Associations Between Systemic Status, Periodontal Status, Serum Cytokine Levels, and Delivery Outcomes in Pregnant Women with a Diagnosis of Threatened Premature Labor

Cited by 92 publications

References 32 publications

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

Therapeutic Efficacy of Leukocytapheresis in a Pregnant Woman with Refractory Adult-onset Still's Disease

Lien entre parodontopathies et prématurité : analyse critique de 15 ans de recherche

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