Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy

Gejl, Anne Kær; Enevold, Christian; Bugge, Anna; Andersen, Marianne; Nielsen, Claus Henrik; Andersen, Lars Bo

doi:10.1038/s41598-019-45976-5

Cited by 122 publications

(114 citation statements)

References 37 publications

(51 reference statements)

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“…Thus, the method used to measure the circulating neurotrophin can introduce bias from one study to another. Serum preparations that allow clotting and BDNF release from platelets retrieve a much higher amount of BDNF, in comparison with measurements of BDNF from blood samples containing anti-coagulants [115].…”

Section: Brain Plasticity Adult Neurogenesis and Physical Activitymentioning

confidence: 99%

Physical Activity and Brain Health

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Proia

et al. 2019

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Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. However, only recently the health consequences of a sedentary lifestyle, and of highly energetic diets, are becoming clear. It has been also acknowledged that lifestyle and diet can induce epigenetic modifications which modify chromatin structure and gene expression, thus causing even heritable metabolic outcomes. Many studies have shown that PA can reverse at least some of the unwanted effects of sedentary lifestyle, and can also contribute in delaying brain aging and degenerative pathologies such as Alzheimer’s Disease, diabetes, and multiple sclerosis. Most importantly, PA improves cognitive processes and memory, has analgesic and antidepressant effects, and even induces a sense of wellbeing, giving strength to the ancient principle of “mens sana in corpore sano” (i.e., a sound mind in a sound body). In this review we will discuss the potential mechanisms underlying the effects of PA on brain health, focusing on hormones, neurotrophins, and neurotransmitters, the release of which is modulated by PA, as well as on the intra- and extra-cellular pathways that regulate the expression of some of the genes involved.

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Section: Brain Plasticity Adult Neurogenesis and Physical Activitymentioning

confidence: 99%

Physical Activity and Brain Health

Liegro

Schiera

Proia

et al. 2019

Genes

232

193

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“…However, circulating BDNF is largely attributable to platelet precursor cells, megakaryocytes, which synthesize BDNF under the platelet BDNF promoter 23 . It is not clear whether circulating BDNF measured in blood reflects brain BDNF levels 24 . Despite the importance of BDNF on brain functions and increasing interest in Val66Met on psychiatric/cognitive symptoms, studies on the effects of Val66Met on cancer-related fatigue are non-existent.…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor polymorphism Val66Met protects against cancer-related fatigue

et al. 2020

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Cancer-related fatigue is an extremely common and debilitating psychiatric symptom that affects up to 80% of cancer patients. Despite its negative impact on the patient’s quality of life, there is no well-established biomarker or mechanisms associated with this debilitating condition. The functional brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism (SNP) has been associated with a variety of psychiatric illnesses. We hypothesized that Val66Met may influence the risk for developing cancer-related fatigue. BDNF Val66Met was analyzed by polymerase chain reaction in 180 patients with confirmed cancer diagnoses. Fatigue was measured using the Functional Assessment of Cancer Therapy-Fatigue (FACIT-Fatigue) questionnaire. Depression was measured using the Hamilton Depression Scale (HAM-D). Data were transformed when necessary and regression models were constructed to access the association between genotype and symptom severity. Participants carrying the Met allele reported significantly less fatigue compared to the Val/Val genotype group. The presence of the Met allele did not influence depression levels. The results suggest that the BDNF Val66Met polymorphism confers protective advantage against cancer-related fatigue; whereas having the Val/Val genotype may be a genetic risk factor. Findings from this study not only provide clues to the neural basis of cancer-related fatigue, but also allow for symptom severity prediction and patient education with the goal to improve symptom management.

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“…While under the old concept that posit that the brain was isolated, central measures were relevant, studies have demonstrated that BDNF cross the blood-brain barrier in both directions [6,41]. Studies demonstrating that peripheral and central BDNF levels are associated are further providing support to our approach [42].…”

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confidence: 80%

Among Adolescents, BDNF and Pro-BDNF Lasting Changes with Alcohol Use Are Stage Specific

et al. 2020

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Adolescent alcohol use demonstrates distinct developmental trajectories with dissimilar times of onset and trajectories. Given the importance of brain-derived neurotrophic factor (mature BDNF) in this development stage, the current study investigated its relationship with alcohol use. It also extends the literature by assessing the role of its precursor (pro-BDNF). Therefore, over the span of 5 years, we enrolled and followed participants to define age-related changes in BDNF levels in healthy adolescents. Then, the onset and frequency of alcohol use from ages 11 to 18 were collected to determine how the relationship between alcohol, pro-BDNF, and m-BDNF unfolds over time. With respect to development, analyses demonstrated that BDNF concentration slowly increases throughout adolescence. However, despite having similar basal BDNF levels, compared to controls, adolescents that started drinking before 15 years of age always exhibited lower BDNF levels. They also had a significant decrease in pro-BDNF levels. On the other hand, levels of mature BDNF steadily increased (974.896±275 pg/ml) in those starting alcohol use after the age of 15. Similar to the younger users, a significant drop in pro-BDNF levels was observed over the course of the study. Our results suggested that both pathways may participate in the complex processes of alcohol dependence. The findings highlight the relevance of assessing alcohol-associated changes across the different phases of this vulnerable developmental period. This is the first study evidencing that m-BDNF changes associated with drinking behaviors differed between young and older adolescents. It is also the first article, documenting that drinking during adolescence leads to long-term decreases in pro-BDNF. These results have important implications for policies and programs targeting alcohol use disorders.

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Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy

Cited by 122 publications

References 37 publications

Physical Activity and Brain Health

Physical Activity and Brain Health

Brain-derived neurotrophic factor polymorphism Val66Met protects against cancer-related fatigue

Among Adolescents, BDNF and Pro-BDNF Lasting Changes with Alcohol Use Are Stage Specific

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