Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy

Ferguson, Kelly K.; Kamai, Elizabeth M.; Cantonwine, David E.; Mukherjee, Bhramar; Meeker, John D.; McElrath, Thomas F.

doi:10.1111/aji.13017

Cited by 42 publications

(29 citation statements)

References 34 publications

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“…Moreover, acute atherosis has been linked to increased oxidative stress and lipid content in the decidua of preeclamptic women . Oxidative stress is also implicated in the pathophysiology of preeclampsia and fetal growth restriction . Hence, we proposed that macrophages are implicated in the mechanisms leading to oxidative stress, and therefore, obstetrical disease (ie, acute atherosis).…”

Section: Discussionmentioning

confidence: 99%

The immunophenotype of decidual macrophages in acute atherosis

Gill

Leng

Romero

et al. 2019

American J Rep Immunol

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Problem: Acute atherosis is a uteroplacental arterial lesion that is associated with pregnancy complications such as preeclampsia and preterm birth, the latter being the leading cause of perinatal morbidity and mortality worldwide. However, the immunobiology of acute atherosis is poorly understood. Method of study:Placental basal plate samples were collected from women who delivered with (n = 11) and without (n = 31) decidua basalis lesions of acute atherosis.Multicolor flow cytometry was used to quantify M1-and M2-like macrophage subsets and the expression of iNOS and IL-12 by decidual macrophages. Multiplex fluorescence staining and phenoptics were performed to localize M1-, MOX-, and Mhem-like macrophages in the decidual basalis. Results:Macrophages displayed diverse phenotypes in the decidua basalis with acute atherosis. M2-like macrophages were the most abundant subset in the decidua; yet, this macrophage subset did not change with the presence of acute atherosis. Decidual M1-like macrophages were increased in acute atherosis, and such macrophages displayed a pro-inflammatory phenotype, as indicated by the expression of iNOS and IL-12. Decidual M1-like pro-inflammatory macrophages were localized near both transformed and non-transformed vessels in the decidua basalis with acute atherosis.

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Section: Discussionmentioning

confidence: 99%

The immunophenotype of decidual macrophages in acute atherosis

Gill

Leng

Romero

et al. 2019

American J Rep Immunol

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“…A large proportion of both SGA and LGA cases have unknown causes [ 5 , 8 ]. However, there is mounting evidence that drivers of inflammation and oxidative stress play an important role in fetal development [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal profiles of plasma eicosanoids during pregnancy and size for gestational age at delivery: A nested case-control study

et al. 2020

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Background Inflammation during pregnancy is hypothesized to influence fetal growth. Eicosanoids, an important class of lipid mediators derived from polyunsaturated fatty acids, can act as both direct influences and biomarkers of inflammation through a variety of biological pathways. However, quantifying these distinct inflammatory pathways has proven difficult. We aimed to characterize a comprehensive panel of plasma eicosanoids longitudinally across gestation in pregnant women and to determine whether levels differed by infant size at delivery. Methods and findings Our data come from a case-control study of 90 pregnant women nested within the LIFE-CODES prospective birth cohort study conducted at Brigham and Women's Hospital in Boston, Massachusetts. This study included 31 women who delivered small for gestational age (SGA) babies (SGA, �10th percentile), 28 who delivered large for gestational age (LGA) babies (�90th percentile), and 31 who delivered appropriate for gestational age (AGA) babies (controls, >10th to <90th percentile). All deliveries occurred between 2010 and 2017. Most participants were in their early 30s (median age: 33 years), of white (60%) or black (20%) race/ethnicity, and of normal pre-pregnancy BMI (median BMI: 23.5 kg/m 2). Women provided non-fasting plasma samples during 3 prenatal study visits (at median 11, 25, and 35 weeks gestation) and were analyzed for a panel of eicosanoids. Eicosanoids were grouped by biosynthetic pathway, defined by (1) the fatty acid precursor, including linoleic acid (LA), arachidonic acid (AA), docosahexaenoic acid (DHA), or eicosapentaenoic acid (EPA), and (2) the enzyme group, including cyclooxygenase (COX), lipoxygenase (LOX), or cytochrome P450 (CYP). Additionally, the concentrations of the 4 fatty acids (LA, AA, DHA, and EPA) were measured in maternal plasma. Analytes represent lipids from non-esterified

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“…When oxidative stress levels are too high, it could interfere with normal placentation. The 8-OHdG levels in urine from pregnant women were associated with decreased birthweight, decreased head circumference, and increased risk of small-for-gestational-age fetus 17,18,[31][32][33] . However, the present findings are inconsistent with these data.…”

Section: Discussionmentioning

confidence: 98%

Association between maternal periodontal status and ultrasonographic measurement of fetal growth: A longitudinal study

Taniguchi-Tabata

Takeuchi

Uchida

et al. 2020

Sci Rep

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the aim of this prospective cohort study was to investigate the association between intrauterine fetal growth patterns and periodontal status in pregnant women. fifty-three pregnant women were recruited. periodontitis was diagnosed based on probing pocket depth and clinical attachment level. Maternal urinary 8-hydroxy-2'-deoxyguanosine levels and body mass index were recorded. Ultrasonographic measurements of the biparietal diameter (BpD), abdominal circumference (Ac), and femur length (fL) were recorded, and estimated fetal weight (efW) was calculated. in addition, approximation spline curves of BPD, AC, FL, and EFW were obtained throughout the gestation period. Recorded delivery outcomes were gestational age (GA), birth weight and length, sex, placental weight, and umbilical cord length. Forty-four participants (34.1 ± 4.9 years) were analyzed. Mean neonatal birth weight was 2906.0 ± 544.4 g. On multiple regression analysis, birth weight was related with periodontitis (standardized β = −0.21, P = 0.001). For EFW and BPD, the curves of the periodontitis group were located lower than those of the non-periodontitis group, with significant differences after 32 weeks and 20 weeks of GA, respectively. In conclusion, periodontal treatment before conception may be recommended and a good periodontal condition in the early stage of pregnancy at the latest is desirable for infant growth.

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Associations between repeated ultrasound measures of fetal growth and biomarkers of maternal oxidative stress and inflammation in pregnancy

Abstract: Inflammation and oxidative stress markers measured later in pregnancy were associated with reduced fetal growth as measured by repeated ultrasound scans.

Cited by 42 publications

References 34 publications

The immunophenotype of decidual macrophages in acute atherosis

The immunophenotype of decidual macrophages in acute atherosis

Longitudinal profiles of plasma eicosanoids during pregnancy and size for gestational age at delivery: A nested case-control study

Association between maternal periodontal status and ultrasonographic measurement of fetal growth: A longitudinal study

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